Genome-Wide Tool for Sensitive de novo Identification and Visualisation of Interspersed and Tandem Repeats.

Genomic repeats are functionally ubiquitous structural units found in all genomes. Studying these repeats of different origins is essential for understanding the evolution and adaptation of a given organism. These repeating patterns have manifold signatures and structures with varying degrees of homology, making their identification challenging.

Nickel and human sperm quality: a systematic review.

Background: Reproductive effects of chronic exposure to nickel (Ni), including sperm quality, have been a matter of debate given that published studies yielded contrasting results. We have, therefore, planned to systematically search and analyze medical literature with the aim to ascertain the association of exposure to nickel with the sperm quality in humans.

Materials And Methods: We systematically searched Pubmed, Scopus and Embase for studies reporting the association of Ni with the sperm quality in humans with no time or language limits and used PRISMA to report the findings.

Inflammatory protein levels in asthmatic bronchitis: A study in the Duhok population, Iraq.

Objectives: This study aims to determine the levels of TNF-α, IGF-1, IL-6, and IL-10 protein in blood samples and their potential link to bronchitis-asthma diseases in the Iraq Duhok population, highlighting the prevalence of these long-term inflammatory diseases.

Methods: Sixty blood samples were used and separated into patients (n = 43) and control (n = 17) groups. Serum samples were separated for each individual.

Effect of fertilizing on the productivity of pregnant and lactating queens, growth and development of their offspring.

An urgent problem in the agricultural science of livestock production is the adequate feeding of the queens of farm animals, in particular sheep kept on year-round pasture, especially in the second half of pregnancy and the first half of lactation. These periods are the most stressful, since the uterus does not receive enough necessary nutrients for the normal functioning of the body, embryonic and post-embryonic development of the offspring. In this regard, the purpose of our research was to increase the usefulness of the diet queens by carrying out additional feeding crushed barley with the inclusion of a mineral supplement developed taking into account the chemical composition of feed in Kazakhstan.

Features of internal absorbed dose microdistribution in biological tissue irradiated by 31SiO2 microparticles compared with dose microdistribution from exposure to 56MnO2 particles.

Radiobiological studies are ongoing to understand the consequences of internal exposure to neutron-activated radioactive microparticles, which were sprayed over experimental rats and mice. Special attention in these experiments is given to internal irradiation with radioactive microparticles with short-lived neutron-activated radionuclides 31Si (T1/2 = 2.62 h) and 56Mn (T1/2 = 2.

Human Exposure to Asbestos in Central Asian Countries and Health Effects: A Narrative Review.

The discovery of the detrimental effects of asbestos on human health came long after its widespread use, with the first scientific evidence of asbestos-related diseases emerging in the late 19th and early 20th centuries. Despite efforts to ban its use, asbestos continues to be mined and used in Central Asia (as well as in Russia, China, and other countries). To gain a deeper understanding of the situation in Central Asia, we have conducted a systematic review of scientific literature on the use of asbestos, exposure assessment, and health consequences of asbestos exposure in this geographic area.

Building health systems resilience in Central Asia through nursing and midwifery: evidence to inform policy action.

Background: The recent announcement of the next WHO State of the World's Nursing and Midwifery Reports calls for a review of the state of nursing and midwifery worldwide. In the WHO European region, a broad set of health system reforms have been introduced in Central Asian countries (CACs), namely, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Tajikistan, Turkmenistan and the Republic of Uzbekistan. These reforms have become the focus of a series of sub-regional policy dialogs between CACs, led by government chief nursing and midwifery officers, to accelerate the implementation of a package of policies to strengthen the capacity of nurses and midwives and build health system resilience.

Exploring the interplay of academic stress, motivation, emotional intelligence, and mindfulness in higher education: a longitudinal cross-lagged panel model approach.

Students in higher education often encounter significant academic pressure, which can have profound implications for their mental health and academic performance. The current study employs a two-wave longitudinal design to investigate the dynamic interrelationships among academic stress, academic motivation, emotional intelligence, and mindfulness. The study employed a cross-lagged panel model to investigate the temporal interactions among these four constructs and their influence on the academic experiences of doctoral students.

TB treatment delays and associated risk factors in Dushanbe, Tajikistan, 2019-2021.

Background: In Tajikistan, where there are about 8,000 cases annually, many new cases are being diagnosed with severe disease, indicating a delay in receiving care. We aimed to estimate the proportion with delayed care and the main factors contributing to delayed care.

Methods: Using a retrospective cohort design, we conducted a study that included all people aged over 15 years who were newly diagnosed with pulmonary TB in Dushanbe from 2019 to 2021.

Utilising artificial intelligence for cultivating decorative plants.

Background: The research aims to assess the effectiveness of artificial intelligence models in predicting the risk level in tulip greenhouses using different varieties. The study was conducted in 2022 in the Almaty region, Panfilov village.

Results: Two groups of 10 greenhouses each (area 200 m2) were compared: the control group used standard monitoring methods, while the experimental group employed AI-based monitoring.

Emerging threats in Сentral Asia: Comparative characterization of organic and elemental carbon in ambient PM in urban cities of Kazakhstan.

This study (June 2022-July 2023) investigates the atmospheric concentrations of carbonaceous species, including organic carbon (OC) and elemental carbon (EC), in PM in two major cities in Kazakhstan. Samples were collected from two sites in Almaty (Seifullin and KazNU) and one in Astana. The results showed that Almaty had significantly higher annual average concentrations of OC (10.

MDM2 up-regulates the energy metabolism in NSCLC in a p53-independent manner.

Although an E3 ligase MDM2 is the major negative regulator of the p53 tumor suppressor, a growing body of evidence suggests its p53-independent oncogenic properties. In particular, MDM2 has been shown to regulate serine metabolism independently of p53 status in several types of neoplasia, including NSCLC. Using the GSEA approach and publicly available molecular data on NSCLC tumors, our bioinformatics data suggest that MDM2 affects a number of metabolic genes, particularly those encoding components of the electron transport chain (ETC).

Prevalence of hepatitis B surface antibody among previously vaccinated healthcare workers in Tashkent, Uzbekistan.

Healthcare workers (HCW) have high occupational risk for hepatitis B and Uzbekistan held two HCW vaccination campaigns in 2015 and 2022. Hepatitis B antibody testing (anti-HBs) after Hepatitis B (HepB) vaccination is recommended by the U.S.

Innovative Methods for Reducing Sodium in Cupcakes With Mechanical Leavening and Ozonized Water.

This study developed a technology to prepare cupcakes with a reduced sodium content from fine whole-ground wheat flour and ozonated water. Cavitation technology was utilised to reduce the sodium content, to shorten the cooking time, and to improve the consistency of the dough by accelerated churning. The dough was obtained by cavitation loosening under compressed air pressure and increasing the speed to 900 rpm.

Assessment of the workload of general practitioners in outpatient clinics in Almaty.

Objective: Aim: The purpose of this study is to comprehensively assess the workload of general practitioners using the time study and the WISN method..

Patients And Methods: Materials and Methods: Time studies are used to assess the objective workload of physicians, by measuring the duration of physicians' activities, and the WISN method, which is based on the workload of a health care professional and determines how many health care professionals of a certain type are needed to cope with the workload of a given health care facility.

Evaluation of the result of articular facet reduction and intraoperative distraction for sanders type iv calcaneal fracture n polytraumatized patients.

Objective: Aim: The aim of this study is to evaluate the results of combined repositioning - open repositioning of the depressed articular facet combined with intraoperative two-vector distraction of the calcaneus with a new external fixation distraction apparatus and osteosynthesis with a calcaneal plate with angular stability of a Sanders IV type fracture..

Patients And Methods: Materials and Methods: This study evaluates the results of sequential two-vector distraction with a repositioning apparatus for open reduction and internal fixation (ORIF) of a Sanders IV calcaneal fracture.

Universal technique for information and digital analysis of steel and alloy structures using MATLAB.

There are a large number of computer programs that allow you to automate computational and graphical operations for processing arrays of data and images. The foundations of these areas are very promising in the practice of solving problems of materials science, namely in metallography, based on the analysis of images of structures of metals and alloys. The standards describe various techniques, but they are all performed and calculated manually by the operator.

Analyzing the impact of competitiveness factors on increasing grain production in Kazakhstan and Russia.

The main research objective of this study is to conduct a detailed econometric analysis of the factors affecting the competitiveness of cereal production in Northern Kazakhstan and the Volga region of Russia, focusing on climatic conditions, irrigation systems, and soil cultivation technologies. The assessment of grain production competitiveness was considered for the period 2018-2020 in the context of the following indicators: grain yield, grain sown area, and gross grain harvest. The data analysis also included indicators of annual domestic grain consumption and total grain production in Kazakhstan and Russia.

Electromagnetic Imaging for Breathing Monitoring.

The search for new non-invasive methods of investigating the functioning of human internal organs is an urgent task. One of these methods for assessing the functioning of the human respiratory system is electromagnetic sensing, which is based on a significant difference in the dielectric permittivity of muscle tissue and air. During breathing, when the lungs are filled with air, the dielectric permittivity of the lungs decreases, which leads to a change in the level of the electromagnetic signal passing through the body.

Management of Postpartum Hemorrhage in Low- and Middle-Income Countries: Emergency Need for Updated Approach Due to Specific Circumstances, Resources, and Availabilities.

Postpartum hemorrhage (PPH) represents a critical emergency condition and the principal cause of maternal morbidity and mortality worldwide. It encompasses excessive bleeding following childbirth, which can arise from various causes. Prompt recognition and management are essential to mitigate severe outcomes and ensure maternal safety.

Exploring the Link Between Vitamin B Levels and Metabolic Syndrome Risk: Insights from a Case-Control Study in Kazakhstan.

: Metabolic syndrome (MS) is a collection of metabolic disorders that include insulin resistance, central obesity, dyslipidemia, and hypertension. The prevalence of MS affects 20-30% of adults worldwide, leading to serious health, social, and economic issues. Mitochondrial dysfunction, characterized by mitochondrial DNA (mtDNA) mutations and altered dynamics, plays a pivotal role in MS by impairing glucose oxidation.

Synthesis and Structure of Vanadium-Lead Coatings for Outer Space Structures.

This study aimed to develop a technology for synthesizing non-degrading porous coatings that remain stable under the conditions of outer space. Using the magnetron sputtering method, we obtained vanadium-lead system coatings over a wide range of mutual concentrations from 6 to 44.9 at.

Antimicrobial Mixture Based on Micronized Kaolinite and Ziziphora Essential Oil as a Promising Formulation for the Management of Infected Wounds.

Kaolinite stands out as a promising natural geomaterial for developing new therapeutic systems aimed at addressing global health challenges, such as multidrug-resistant infections. In this study, we report on the formulation and biological activity of a therapeutic mixture composed of white micronized kaolinite (KAO) and Ziziphora essential oil (ZEO), intended for topical application on infected wounds. GC-MS analysis revealed that the primary component of ZEO is pulegone, constituting 72.