Identification and management of Bipolaris sorokiniana in wheat and barley in Southeast Kazakhstan.

Wheat and barley serve as significant nutrient-rich staples that are extensively grown on a global scale, spanning over 219 million hectares. The annual combined global yield is 760.9 million tons, with Kazakhstan contributing 14.

Late-onset Systemic Lupus Erythematosus.

Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease (ARD) that results from the dysregulation of multiple innate and adaptive immune pathways. Late-onset SLE (Lo-SLE) is the term used when the disease is first diagnosed after 50-65 years, though the standard age cut-off remains undefined. Defining "late-onset" as lupus with onset after 50 years is more biologically plausible as this roughly corresponds to the age of menopause.

Radioactive contamination of southeast Abai oblast, Kazakhstan, from the Chinese nuclear weapons testing program at Lop Nor: an analytical review.

Between 1949 and 1962 the Soviet Union performed atmospheric tests of nuclear weapons at the Semipalatinsk nuclear test site (SNTS) in Kazakhstan, resulting in widespread contamination of the surrounding region with radioactive fallout. Settlements in the southeast Abai oblast of Kazakhstan, close to the border with China, are not thought to have received significant fallout from the SNTS. There is, however, evidence that the study area, including Makanchi, Urdzhar and Taskesken villages, was contaminated by atmospheric nuclear tests performed by China at the Lop Nor NTS between 1964 and 1980.

A comprehensive voice dataset for Hindko digit recognition.

Hindko is a language primarily spoken in Northwestern areas of Pakistan. Approximately eight million people speak the Hindko language. According to its native speakers, it is 7 largest language of Pakistan and 2 largest language of Khyber Pakhtunkhwa.

A review on WO photocatalysis used for wastewater treatment and pesticide degradation.

The rapid growth in the global population has led to increased environmental pollution and energy demands, exacerbating the issue of environmental contamination. This contamination is significantly impacted by various types of pesticides found in water sources, which pose serious health risks to humans, animals, and aquatic ecosystems. In response, extensive research into water treatment technologies has been conducted, focusing on efficient methods to remove these pollutants, with advanced oxidation processes and the utilization of tungsten trioxide (WO) as a photocatalyst showing promising results.

Enhanced electrochemical performance of a polyaniline-based supercapacitor by a bicontinuous microemulsion nanoreactor approach.

Polyaniline (PANI)-based supercapacitors suffer from environmental and mechanical instabilities. In this work, a novel bicontinuous microemulsion approach was developed to fabricate a unique nanofibre structure of polyaniline and its 3D-crosslinked network using crosslinking chemistry, which improved both the mechanical and electrochemical performance of a PANI-based supercapacitor. The polyaniline nanofibers and its 3D-crosslinked networks produced by bicontinuous nanoreactors were investigated using experimental tools, such as SEM, FTIR, BET, TGA and DSC.

Colorectal cancer and microbiota: systematic review.

Introduction: The gut microbiome maintains the mucus membrane barrier's integrity, and it is modulated by the host's immune system.

Aim: To detect the effect of microbiota modulation using probiotics, prebiotics, symbiotics, and natural changes on colorectal cancers (CRCs).

Methods: A PubMed search was conducted to retrieve the original and articles published in English language from 2010 until 2021 containing the following keywords: 1) CRCs, 2) CRCs treatment (i.

The Combined Effect of Multisensory Stimulation and Therapist Support on Physical and Mental Health of Older Adults Living in Nursing Homes: Pilot Randomized Controlled Trial.

Background: Increasing life expectancy has led to a rise in nursing home admissions, a context in which older adults often experience chronic physical and mental health conditions, chronic pain, and reduced well-being. Nonpharmacological approaches are especially important for managing older adults' chronic pain, mental health conditions (such as anxiety and depression), and overall well-being, including sensory stimulation (SS) and therapist support (TS). However, the combined effects of SS and TS have not been investigated.

Effect of pre-treatment conditions on the electrochemical performance of hard carbon derived from bio-waste.

Sodium-ion batteries (SIBs) offer several advantages over traditional lithium-ion batteries, including a more uniform sodium distribution, lower-cost materials, and safer transportation options. A promising development in SIBs is the use of hard carbons as anode materials due to their low insertion voltage and larger interlayer spacing, which improve sodium-ion insertion. Traditionally, hard carbons are made from costly carbon sources, but recent advancements have focussed on using abundant bio-waste, like coffee grounds.

Biochar for ameliorating soil fertility and microbial diversity: From production to action of the black gold.

This article evaluated different production strategies, characteristics, and applications of biochar for ameliorating soil fertility and microbial diversity. The biochar production techniques are evolving, indicating that newer methods (including hydrothermal and retort carbonization) operate with minimum temperatures, yet resulting in high yields with significant improvements in different properties, including heating value, oxygen functionality, and carbon content, compared to the traditional methods. It has been found that the temperature, feedstock type, and moisture content play critical roles in the fabrication process.

Environmental impact of the launch vehicle "Soyuz-FG" emergency falling in Kazakhstan.

On October 11, 2018, in the Ulytau region of the Republic of Kazakhstan, the Soyuz-FG launch vehicle carrying a crewed MS-10 spacecraft failed. It resulted in the release into the fragile arid ecosystems of rocket propellants, i.e.

Spontaneous heat current and ultra-high thermal rectification in asymmetric graphene: a molecular dynamics simulation.

Non-equilibrium molecular dynamics (NEMD) simulations reveal the existence of a spontaneous heat current (SHC) in the absence of a temperature gradient and demonstrate ultra-high thermal rectification in asymmetric trapezoid-shaped graphene. These unique properties have potential applications in power generation and thermal circuits, functioning as thermal diodes. Our findings also show the presence of negative and zero thermal conductivity in this system.

Emerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research.

This review explores the current understanding and recent advancements in neuroblastoma, one of the most common extracranial solid pediatric cancers, accounting for ~ 15% of childhood cancer-related mortality. The hallmarks of NBL, including angiogenesis, metastasis, apoptosis resistance, cell cycle dysregulation, drug resistance, and responses to hypoxia and ROS, underscore its complex biology. The tumor microenvironment's significance in disease progression is acknowledged in this study, along with the pivotal role of cancer stem cells in sustaining tumor growth and heterogeneity.

: a historical, genetic, and conservational perspective of the primary progenitor species of domesticated apples.

Apples are one of the most valued tree fruit crops around the world. Currently, a few highly popular and economically successful apple cultivars dominate the commercial production and serve as main genetic contributors to the development of new apple cultivars. This limited level of genetic diversity grown as a clonally propagated monoculture renders the apple industry vulnerable to the wide range of weather events, pests, and pathogens.

Advances in Porous Structure Design for Enhanced Piezoelectric and Triboelectric Nanogenerators: A Comprehensive Review.

Porous structures offer several key advantages in energy harvesting, making them highly effective for enhancing the performance of piezoelectric and triboelectric nanogenerators (PENG and TENG). Their high surface area-to-volume ratio improves charge accumulation and electrostatic induction, which are critical for efficient energy conversion. Additionally, their lightweight and flexible nature allows for easy integration into wearable and flexible electronics.

Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry.

Background And Aims: Overweight and obesity are modifiable risk factors for atherosclerotic cardiovascular disease (ASCVD) in the general population, but their prevalence in individuals with heterozygous familial hypercholesterolaemia (HeFH) and whether they confer additional risk of ASCVD independent of LDL cholesterol (LDL-C) remains unclear.

Methods: Cross-sectional analysis was conducted in 35 540 patients with HeFH across 50 countries, in the EAS FH Studies Collaboration registry. Prevalence of World Health Organization-defined body mass index categories was investigated in adults (n = 29 265) and children/adolescents (n = 6275); and their association with prevalent ASCVD.

The latest in clinical trial results of 5-alpha reductase inhibitors in combination regimens for benign prostatic hyperplasia.

Introduction: BPH/male LUTS is a prevalent condition in the aging male population with multifactorial pathophysiology. Pharmacotherapy remains the cornerstone of treatment in patients who fail conservative treatment. 5-α-Reductase inhibitors (5-ARIs) are the only class of medication shown to reduce the risk of acute retention and BPH-related surgery and, thus, are commonly used along with other "short acting" medications in combination treatments.

Occupational exposure and sarcoidosis: a case-control study in three countries.

Background: Preceding studies of environmental and occupational risk factors of sarcoidosis yielded inconsistent findings.

Aims: We aimed to ascertain the occupational risk factors for sarcoidosis in a case-control study.

Methods: A total of 237 sarcoidosis patients with a histologically confirmed diagnosis were matched with 474 controls for sex and age (median 49, interquartile range 37; 60 years) recruited from the university hospitals and outpatient centres in Belarus, Kazakhstan and the Russian Federation.

Evaluating student understanding of core pharmacokinetic concepts.

Both educators and graduates have expressed concern about a perceived pharmacology knowledge gap that includes difficulty applying fundamental principles to clinical and research problems. Consequently, we sought to determine the extent to which current students can explain the meaning of, and appropriately apply, a subset of core concepts, and to identify any misconceptions arising from the responses. Of the twenty-four pharmacology core concepts arising from the recent international collaboration, four pharmacokinetic concepts were chosen, namely drug bioavailability, drug clearance, volume of distribution, and steady-state concentration.

Serum levels of thyroxine, thyroid-stimulating hormone, and anti-thyroid peroxidase antibodies and their association with anxiety in environmentally exposed populations in Kazakhstan.

Little is known about the impact of environmental pollution on thyroid function in the non-occupationally exposed population of Kazakhstan. This study aimed to investigate serum levels of thyroxine (T4), thyroid-stimulating hormone (TSH), and anti-thyroid peroxidase (TPO) antibodies in the environmentally exposed population of Kazakhstan in relation to symptoms of anxiety. A total of 1,388 nominally healthy individuals residing in areas exposed to three major types of environmental pollution prevalent in Kazakhstan-non-ferrous metallurgy, condensate gas extraction, and activities of the Semipalatinsk Nuclear Test Site (SNTS)-were enrolled.

Environmental impact of microplastic emissions from wastewater treatment plant through life cycle assessment.

This study aimed to quantify the environmental impact of microplastic (MP) emissions from wastewater treatment plants (WWTPs) using life cycle assessment (LCA). The investigation comprehensively evaluated the contribution of MPs to overall WWTP midpoint and endpoint impacts, with a detailed analysis of the influence of particle size, shape, polymer type, and the environmental costs and benefits of individual wastewater treatment processes on MP removal. The LCA model was developed using SimaPro software, with impact assessments conducted via the USEtox framework and the IMPACT World+ methodology.

Demographic Characteristics and Treatment Outcomes of Intracranial Atherosclerosis Stenting: A Retrospective Case-Series of 216 Consecutive Patients.

Intracranial atherosclerosis (ICAS) is a major cause of ischemic stroke, disproportionately affecting populations with significant vascular risk factors. Although ICAS imposes a considerable health burden, research on this condition in Central Asia remains scarce, especially among the Kazakh population. This study analyzes demographic characteristics, treatment outcomes, and procedural challenges associated with ICAS in 216 patients treated at a single institution.

The Impact of Genetic Polymorphism on Complication Development in Heart Failure Patients.

Despite the high progress that has been made in the field of cardiology, the left ventricular assist device (LVAD) can still cause complications (thrombosis/bleeding) in heart failure (HF) patients after implantation. Complications develop due to the incorrect dose of antithrombotic therapy, due to the influence of the non-physiological shear stress of the device, and also due to inherited genetic polymorphisms. Therefore, the aim of our study is to identify the influence of the genetic polymorphisms on complication development in HF patients with implanted LVADs with prescribed antiplatelet therapy.

Cybersecurity Solutions for Industrial Internet of Things-Edge Computing Integration: Challenges, Threats, and Future Directions.

This paper provides the complete details of current challenges and solutions in the cybersecurity of cyber-physical systems (CPS) within the context of the IIoT and its integration with edge computing (IIoT-edge computing). We systematically collected and analyzed the relevant literature from the past five years, applying a rigorous methodology to identify key sources. Our study highlights the prevalent IIoT layer attacks, common intrusion methods, and critical threats facing IIoT-edge computing environments.

Cyclic Imines and Their Salts as Universal Precursors in the Synthesis of Nitrogen-Containing Alkaloids.

Alkaloids are predominantly nitrogen-containing heterocyclic compounds that are usually isolated from plants, and sometimes from insects or animals. Alkaloids are one of the most important types of natural products due to their diverse biological activities and potential applications in modern medicine. Cyclic imines were chosen as starting compounds for the synthesis of alkaloids due to their high synthetic potential.