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Ziziphora clinopodioides flavonoids based on network pharmacology attenuates atherosclerosis in rats induced by high-fat emulsion combined with vitamin D by down-regulating VEGF/AKT/NF-κB signaling pathway.
Biomed Pharmacother
September 2020
College of Pharmacy, Xinjiang Medical University, Urumqi, 830000, Xinjiang, China; Xinjiang Academy of Analysis and Testing, Xinjiang Uygur Autonomous Region, Department of Science and Technology, Urumqi, 830000, Xinjiang, China; Department of Pharmacy, The Fourth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China; Department of Pharmacy, Kazakh Medical Hospital in Altay Region, Altay, 836500, Xinjiang, China. Electronic address:
Ziziphora clinopodioides flavonoids (ZCF) is a major bioactive total flavonoids compound isolated from Ziziphora clinopodioides Lam. It has been long used as an anti-atherosclerosis (AS) in clinics. However, anti-AS effects of ZCF have not been fully investigated.
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