113 results match your criteria: "Kayseri Eğitim ve Araştirma Hospital[Affiliation]"

Rhodococcus equi (R. equi) is a primary cause of pyogranulomatous pneumonia of foals between three weeks and five months of age. Early diagnosis of rhodococcal pneumonia has always been considered a preferable approach as it can lead to more successful treatment and better outcomes.

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Purpose: Gastrointestinal (GI) dysfunction is common in critically ill patients and associated with poor outcomes. There is a lack of standardised methods for daily monitoring of GI function. COSMOGI aimed to develop a Core Outcome Set (COS) for daily monitoring of GI function to improve consistency and comparability in future studies in critically ill patients.

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Histopathological Comparison of Various Tongue Base Reduction Processes.

Niger J Clin Pract

November 2024

Department of Otolaringology, Head and Neck Surgery, Kayseri City Education and Training Hospital, Kayseri, Turkey.

Background And Aim: Tongue base reduction surgery is the only minimally invasive technique that can be performed under local anesthesia as an outpatient procedure, especially to treat obstructive sleep apnea caused by hypopharyngeal obstruction. Studies reported that various devices could be used for tongue base reduction, but comparisons of these methods are limited in the literature. Our study aimed to compare the histological effects of tongue base reduction methods performed with the Celon radiofrequency, monopolar cautery, Coblator, and Sutter devices on the tissue.

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Article Synopsis
  • Dual antiplatelet therapy (DAPT) is essential for managing acute and chronic coronary syndromes, helping to lower mortality rates and prevent further complications.
  • A study followed 1500 patients on a specific fixed-dose DAPT (ASA + clopidogrel) to evaluate its effectiveness and safety, primarily focusing on hospitalization and bleeding risks.
  • Results indicated that the fixed-dose combination therapy was effective, with low rates of hospitalization for cardiovascular issues and minimal bleeding complications in appropriately selected patients.
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Introduction: Topical therapies are used in almost all patients with psoriasis. A novel fixed topical combination cream (GN-037) with a lower concentration (0.0356%) of clobetasol 17-propionate (CP) was developed together with urea, salicylic acid, and retinoic acid to provide a better benefit-risk ratio.

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Aim: Research on the effects of methylphenidate on female fertility is limited. This study evaluated the effects of methylphenidate on reproductive function, oxidants, antioxidants, proinflammatory cytokines, prolactin, and cortisol in female rats.

Methods: Forty-eight albino Wistar female rats were divided into four groups consisting of 12 rats, which were given pure water orally once daily for 7 days (HG-1), 10 mg/kg methylphenidate orally once daily for 7 days (MP-1), pure water orally once daily for 30 days (HG-2), and 10 mg/kg methylphenidate orally once daily for 30 days (MP-2).

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Effect of ethyl acetate extract from Usnea longissima on chemotherapy-associated multiple organ dysfunction in rats.

Biomed Pharmacother

December 2024

Department of Pathology, Faculty of Veterinary, Erciyes University, Kayseri 38280, Turkey. Electronic address:

Background: The toxic effects of doxorubicin and cisplatin in various organs have been associated with oxidative stress. Studies have shown that Usnea longissima has strong antioxidant effects. This study aimed to investigate the protective effect of ethyl acetate extract from Usnea longissima (ULE), which is known to have strong antioxidant effects, on chemotherapeutic-induced heart, kidney, liver, and ovarian toxicity.

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Article Synopsis
  • In Turkey, a single-dose varicella vaccine was introduced in February 2013, aiming to reduce hospitalizations related to chickenpox among children under 18 years old.
  • A study analyzed hospitalization data from 2008 to 2018, comparing rates before and after the vaccine's introduction, finding a significant decrease in hospitalizations (3.79 to 2.87 per 100,000 children per year).
  • The most notable reduction was in children aged 1-5 years, with a 60.2% drop in hospitalizations post-vaccine, demonstrating the vaccine's effectiveness in preventing severe cases of varicella.
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  • AI platforms are important tools in genetics and medicine, helping to analyze lots of patient data and find new diseases.
  • They are making it possible to better understand complex health issues and improve treatments for things like rare diseases and cancers.
  • These technologies are helping doctors make better decisions for patient care, leading to more personalized and effective treatments.
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Objectives: We investigated the efficacy of the erector spinae plane block, which has been proven to be effective in breast surgery, on intraoperative opioid consumption and postoperative analgesia when administered in different volumes with the same concentration of local anesthetic.

Methods: This study is designed as randomized, prospective, and double-blind. Seventy patients aged between 18-70 years, undergoing ASA I-III elective breast surgery, were included.

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Article Synopsis
  • Nonviral vectors like liposomes are being researched for delivering genes specifically to cancer cells.
  • Liposomes are tiny bubbles made of fats that help protect and transport genetic materials, making them better than older methods that often missed their targets.
  • This review looks at how liposomes can improve gene therapy for cancer, what challenges they face, and what new ideas might make them even better in the future.
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Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives.

Mil Med Res

June 2024

Department of General SurgeryInstitute of Precision Diagnosis and Treatment of Digestive System Tumors and Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen University, Shenzhen, Guangdong, 518055, China.

Article Synopsis
  • - Neuroendocrine neoplasms (NENs) are diverse tumors that originate from neuroendocrine cells, with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) being the most common type.
  • - Recent studies show that GEP-NENs are becoming more prevalent and may have a more aggressive nature than previously thought, leading to limited life expectancy for patients.
  • - The review highlights the need for improved research on diagnosis and management of GEP-NENs, addressing current limitations in understanding their epidemiology, clinical features, and treatments.
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Objective: The aim of this study is to determine whether there is a relationship between peritoneal membrane permeability and dyspepsia in peritoneal dialysis patients.

Patients And Methods: This study included 95 peritoneal dialysis patients aged 18 and older. The presence of dyspepsia in patients was recorded according to the 2016 ROME-IV Functional Dyspepsia Diagnostic Criteria.

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Background: The purpose of this study is to determine the significance of markers such as C-reactive protein, procalcitonin, complete blood count parameters, delta neutrophil index, ischemia-modified albumin, presepsin, and oxidative stress indicators, which are associated with inflammation, oxidative stress, and ischemia in the pathology and diagnosis of acute cholecystitis in adults.

Methods: Patients diagnosed with acute cholecystitis in the emergency department and healthy individuals in the control group were included in the study. Routine blood count and biochemistry analyses were performed on the participants.

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Objective: The MORtality in CORonary Care Units in Türkiye (MORCOR-TURK) trial is a national registry evaluating predictors and rates of in-hospital mortality in coronary care unit (CCU) patients in Türkiye. This report describes the baseline demographic characteristics of patients recruited for the MORCOR-TURK trial.

Methods: The study is a multicenter, cross-sectional, prospective national registry that included 50 centers capable of 24-hour CCU service, selected from all seven geographic regions of Türkiye.

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Objective: The metabolic equivalent (MET) and Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery (SYNTAX) score are two parameters with known cardiovascular prognostic significance. In this study, we aimed to investigate the direct relationship between MET and SYNTAX score in patients with chronic coronary syndrome (CCS).

Method: This retrospective study included 200 patients over 18 years of age who underwent coronary angiography and had a positive exercise electrocardiography test result.

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Pediatric kidney care experience after the 2023 Türkiye earthquake.

Nephrol Dial Transplant

August 2024

İstanbul University - Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Pediatric Nephrology, İstanbul, Türkiye.

Article Synopsis
  • Two devastating earthquakes in Türkiye on February 6, 2023, resulted in significant injuries to 903 children, with a focus on crush syndrome-related acute kidney injury (Crush-AKI) and mortality.
  • The study tracked various factors, including the time under rubble, treatment protocols, and patient outcomes, revealing that Crush-AKI developed in 36% of the patients, and over half required dialysis.
  • Key findings included that serum levels of creatine phosphokinase above 20,950 U/L and inadequate initial intravenous fluid volume were linked to Crush-AKI, and most deaths occurred among those with Crush-AKI within the first four days of admission.
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Article Synopsis
  • The study assessed the impact of Rhinapi nasal spray on allergic rhinitis symptoms among 10,000 participants in Turkey over a 3-week period.
  • The treatment led to significant improvements in total symptom scores, quality of life (QoL) scores, and otolaryngological examination scores, with statistically significant changes before and after usage.
  • The findings suggest that Rhinapi effectively reduces symptoms of allergic rhinitis and can be considered as an additional treatment option for those affected.
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Nanostructures for site-specific delivery of oxaliplatin cancer therapy: Versatile nanoplatforms in synergistic cancer therapy.

Transl Oncol

January 2024

Department of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Electronic address:

As a clinically approved treatment strategy, chemotherapy-mediated tumor suppression has been compromised, and in spite of introducing various kinds of anticancer drugs, cancer eradication with chemotherapy is still impossible. Chemotherapy drugs have been beneficial in improving the prognosis of cancer patients, but after resistance emerged, their potential disappeared. Oxaliplatin (OXA) efficacy in tumor suppression has been compromised by resistance.

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To investigate coronavirus disease 2019 (COVID-19) in infants aged 0 to 3 months because there is currently a significant gap in the literature on the subject. A cross-sectional study was conducted with the involvement of 19 medical centers across Turkey and 570 infants. The majority of the patients were male (58.

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Article Synopsis
  • The study examined the effects of curcumin and umbilical cord-derived mesenchymal stem cells (UC-MSCs) on healing tendon injuries in rats, both individually and in combination.
  • Eighty female rats were divided into five treatment groups, each receiving different interventions following the creation of tendon defects.
  • Results showed that while both curcumin and UC-MSCs improved healing compared to a control group, no treatment was found to be significantly more effective than the others.
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[Pain beliefs of cancer patients and associated factors].

Agri

October 2023

Department of General Surgery Intensive Care, Kayseri City Hospital, Kayseri, Türkiye.

Objectives: The aim is to determine the pain beliefs and related factors of cancer patients.

Methods: The study was designed as a descriptive and analytical type. It was completed between January and June 2019 with 100 individuals who were 18 years of age or older, who were receiving chemotherapy, and who agreed to participate in the study.

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Management of Priapism: Results of a Nationwide Survey and Comparison with International Guidelines.

Urol Res Pract

July 2023

Department of Urology, Section of Andrology, Istanbul University, Istanbul School of Medicine, Istanbul, Turkey On Behalf of Turkish Urology Academy.

Objective: The aim of this study is to evaluate current urologic practice regarding the management of priapism in Turkey and compare with international guidelines.

Methods: Urologists and urology residents were invited to an online survey consisting of 30 multiple-choice questions on priapism-related clinical practices that were consid- ered most important and relevant to practices by using Google Forms.

Results: Total number of responses was 340.

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Background: Atrial fibrillation (AF) is a common cardiac rhythm disorder associated with hemodynamic disruptions and thromboembolic events. While antiarrhythmic drugs are often recommended as the initial treatment, catheter ablation has emerged as a viable alternative. However, the recurrence of AF following ablation remains a challenge, and there is growing interest in exploring inflammatory markers as predictors of recurrence.

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