Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia.

X-linked hypophosphataemia (XLH) is a rare metabolic bone disorder caused by pathogenic variants in the PHEX gene, which is predominantly expressed in osteoblasts, osteocytes and odontoblasts. XLH is characterized by increased synthesis of the bone-derived phosphaturic hormone fibroblast growth factor 23 (FGF23), which results in renal phosphate wasting with consecutive hypophosphataemia, rickets, osteomalacia, disproportionate short stature, oral manifestations, pseudofractures, craniosynostosis, enthesopathies and osteoarthritis. Patients with XLH should be provided with multidisciplinary care organized by a metabolic bone expert.

Strategic use of new generation antidepressants for depression: SUN(^_^) D protocol update and statistical analysis plan.

Background: SUN(^_^)D, the Strategic Use of New generation antidepressants for Depression, is an assessor-blinded, parallel-group, multicenter pragmatic mega-trial to examine the optimum treatment strategy for the first- and second-line treatments for unipolar major depressive episodes. The trial has three steps and two randomizations. Step I randomization compares the minimum and the maximum dosing strategy for the first-line antidepressant.

The effects of different ecophysiological factors on ochratoxin A production.

Mycotoxin biosynthesis is affected by peculiar agro-ecosystem dependent conditions. Accordingly, the correlation between mycotoxin contamination and environmental condition change scenarios should be carefully considered. This is because fungal colonization and mycotoxin contamination could critically impair the availability of food products, especially in poor countries.

Percutaneous epiphysiodesis for leg length discrepancy.

This study presents a retrospective evaluation of 57 patients who underwent a percutaneous epiphysiodesis for leg length discrepancy. Of these patients, 68.5% presented with a good result with a final leg length discrepancy of less than 1.

Preliminary results of a phase I study with MTA (LY231514) in combination with cisplatin in patients with solid tumors.

MTA (multitargeted antifolate, LY231514) is a novel antimetabolite resulting from structure/activity studies of the lometrexol-type antifolates. It has been shown to inhibit various enzymes of folate pathways and has broad antitumor activity in a variety of in vitro and in vivo tumor models. Clinical phase 1 studies have been performed using different administration schedules, and subsequently the every-21-days schedule has been selected for further development.

Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin.

Purpose: Multitargeted antifolate (MTA; LY231514) has broad preclinical antitumor activity and inhibits a variety of intracellular enzymes involved in the folate pathways. This study was designed to (1) determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLT), and pharmacokinetics of MTA combined with cisplatin; (2) determine a recommended dose for phase II studies; and (3) collect anecdotal information on the antitumor activity of MTA combined with cisplatin.

Patients And Methods: Patients with solid tumors received MTA intravenously over 10 minutes and cisplatin over 2 hours once every 21 days.

Exploring interlimb constraints during bimanual graphic performance: effects of muscle grouping and direction.

Past studies on bimanual coordination have revealed a general preference to move the limbs in a symmetrical fashion, also denoted as the in-phase mode. Its counterpart, the asymmetrical or anti-phase mode, is performed with lower degrees of accuracy and stability. This ubiquitous tendency to activate the homologous muscle groups is referred to as the muscle grouping constraint (egocentric constraint).

Therapeutic possibilities and limits of vitreoretinal surgery after expulsive choroidal hemorrhage.

The aim of this retrospective study was to demonstrate that in certain cases of expulsive choroidal hemorrhage (ECH) anatomical success and useful vision can be obtained with repeated vitreoretinal surgery. The authors report on their experience in 8 patients who were treated following ECH over the past 3 1/2 years. Three types of ECH could be identified.

Control of asymmetrical bimanual movements.

When movements are performed together in the upper-limbs, a strong tendency emerges to synchronize the patterns of motor output. This is most apparent when trying to do different things at the same time. The present experiment explored the simultaneous organization and control of spatiotemporally different movements.