LncRNA-miRNA-mRNA regulatory axes as potential biomarkers in cervical cancer: a comprehensive overview.

Despite the recent advances in vaccination and treatment strategies, cervical cancer continues to claim numerous lives every year. Owing to the fact that non-coding RNAs (ncRNAs) such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) interact with coding transcripts, and effectuate key roles in the tumorigenesis and metastasis of cervical cancer, there has been extensive research in recent years to explore their potential as biomarkers for early detection, or as therapeutic targets. Through this review, we aim to provide a comprehensive overview of the recent advancements in discoveries about cervical cancer-associated lncRNA-miRNA-mRNA axes, their dysregulation, and their roles in various signaling pathways associated with the growth, survival, invasion, and metastasis of cervical cancer cells.

Life-threatening dapagliflozin-associated euglycaemic diabetic ketoacidosis in a postoperative patient.

Euglyceamic diabetic ketoacidosis (EuDKA) is an uncommon but serious diabetes mellitus complication associated with risk factors such as fasting, surgery, pregnancy and, more recently, the use of sodium-glucose cotransporter-2 inhibitors (SGLT2i). This case is of a woman with type 2 diabetes and hypertension in her 50s who underwent an incarcerated umbilical hernia repair and abdominoplasty. Two days after discharge, she was readmitted with nausea, vomiting, loss of appetite, low-grade fever and breathing difficulty.

Navigating trends in research related to vestibular function tests through scientometrics.

Purpose: Research on vestibular function tests has advanced significantly over the past century. This study aims to evaluate research productivity, identify top contributors, and assess global collaboration to provide a comprehensive overview of trends and advancements in the field.

Method: A scientometric analysis was conducted using publications from the Scopus database, retrieved on January 5, 2024.

Ethical Use of Cadaveric Images in Anatomical Textbooks, Atlases, and Journals: A Consensus Response From Authors and Editors.

Nowadays, consent to use donor bodies for medical education and research is obtained from the body donors and their families before the donation. Recently, the International Federation of Associations of Anatomists (IFAA) published guidelines that could restrict the appearance of cadaveric images in commercial anatomical resources such as textbooks and other educational products. These guidelines state that the donor must expressly consent to using such images for this purpose.

Comparing and assessing physical activity and sedentary behaviour guidelines for different populations with and without chronic conditions and/or disabilities: a systematic review protocol.

Physical activity guidelines targeting different populations with and without chronic diseases or disabilities are required to meet the diverse functional and physiological needs experienced by different subgroups of people to achieve optimal health benefits. As the importance of physical activity guidelines in promoting optimal health and well-being becomes increasingly recognised, there is a critical need for their systematic evaluation to ensure they remain effective, applicable and aligned with evolving health needs and scientific insights. This study aims to systematically review, critically evaluate, and compare global physical activity and sedentary behaviour guidelines on frequency, intensity, time, and type of exercise for adults, pregnant and postpartum women, and people living with chronic conditions and/or disabilities.

COPD in females- Seeing through the smoke.

Chronic obstructive pulmonary disease (COPD) is a type of lung disease marked by permanent damage to tissues in the lungs. Over time, chronic obstructive pulmonary disease (COPD) can make breathing difficult due to permanent lung damage. COPD encompasses two main conditions chronic bronchitis, where inflammation and scarring narrow the large airways, and emphysema, where the tiny air sacs in the lungs are damaged.

The Use of "Cancer Ratio" in Differentiating Malignant and Tuberculous Pleural Effusions: Protocol for a Prospective Observational Study.

Background: Differentiating between tuberculosis and malignancy as the cause of an exudative lymphocyte predominant pleural effusion is difficult due to similarities in the cellular and biochemical characteristics of the pleural fluid in both conditions. Microbiological tests in tubercular pleural effusions have a poor diagnostic yield, and the long turnaround time for results prevents an early diagnosis. The diagnosis of malignant pleural effusion (MPE) is hampered by a variable yield of pleural fluid cytology and closed pleural biopsy and the fact that thoracoscopy may not be readily available or feasible in each patient.

Gastric Cytology: A Supplement to Early Diagnosis of Gastric Malignancies.

Introduction: Gastric malignancies are one of the leading causes of morbidity and mortality globally. Rapid accurate interpretation of gastric cytology aids in early diagnosis and management. This study evaluates the utility of gastric cytology in diagnosing gastric malignancies.

Sudden vision loss in pregnancy: Wernicke's encephalopathy in a patient with hyperemesis gravidarum.

Wernicke's encephalopathy, the acute phase of Wernicke-Korsakoff syndrome, is characterised as a triad of altered mental status, ocular signs and ataxia. Our patient presented with hyperemesis gravidarum, which is a rare aetiology of Wernicke's encephalopathy. The patient did not have any oculomotor abnormalities, which are more common and classically described in Wernicke's triad.

Efficacy and Safety of Fluconazole Mucoadhesive Patches in Human Immunodeficiency Virus-Related Oral Candidiasis.

Background: Opportunistic fungal infections like oral candidiasis account for a significant amount of morbidity in HIV disease and an indicator of immune suppression. Fluconazole is a broad-spectrum antifungal agent that has been extensively used in the management of oral, candidiasis. Highly efficacious fluconazole is also known to have systemic toxicity due to high drug interaction and hence the present study focuses on the formulation of bioadhesive film as a controlled release carrier for fluconazole.

Prevalence of Dysphonia Among School Going Children in Dakshina Kannada District in Karnataka.

Objective: Voice disorders among children are quite common, probably due to the excessive and phonotraumatic voice use patterns. Global prevalence falls between 1.4% and 53.

Low-dose radiation research insights in experimental animals: A gateway to therapeutic implications.

In recent years, a significant research effort has been underway to explore the effects of low-dose radiation (LDR). Animal models play a key role in various fields of research, including biomedicine, pharmaceutical, environmental, and behavioral studies. The use of animal models has been an invaluable tool in radiation research for understanding radiation biology, assessing radiation risks, and developing strategies for radiation protection and medical management.

Bridging knowledge gaps: impact of remedial classes on first-year medical students in biochemistry - a cross-sectional study.

Background: Remedial teaching is a tailored educational approach dedicated to enhancing the academic performance of students facing challenges within the curriculum. By identifying and addressing specific learning difficulties, it provides essential support and guidance to bring students closer to expected standards while preventing future setbacks. We hypothesize that underperforming medical students who receive daily, tailored remediation will demonstrate significant improvement in their formative and summative assessment scores in biochemistry.

Aesthetic Facial Surgery: a Systematic Review.

The field of facial cosmetic surgery is rapidly expanding and becoming more well-known worldwide. Over the past century, there have been notable developments in medical technology, accessibility to resources, and patient demand for facial plastic surgery in India, a country that has become a global leader in this sector. This study aims to perform a thorough evaluation of current trends and past practises in aesthetic operations and facial plastic surgery in India.

A study on bisphenol induce renal damage and role of vitamin c as an antioxidant on bisphenol induced renal damage in wistar rats. A case control study.

Introduction: Bisphenol A (BPA) is considered one of the most common industrial manufactured chemicals and a pollutant. oxidative stress has been induced by bisphenol by dysregulate the cytokines. Oxidative stress induced by BPA is known to affect the brain, liver, and kidneys.

Evaluation of pattern and distribution of bronchiectasis in high resolution computed tomography and its correlation with etiological factors.

Background: Etiological diagnosis is essential in bronchiectasis for proper management as improperly managed bronchiectasis often worsens over a period of time. Etiological diagnosis of bronchiectasis depends on history, clinical features and HRCT scan. Recognition of the pattern of involvement & distribution of bronchiectasis in HRCT is useful to outline the differential diagnosis, map the complications and, hence, guide the further management in bronchiectasis.

Phonological Awareness and Word Decoding Skills in the Early Readers of Kannada.

Background: Phonological awareness has been recognized as a significant predictor of word-decoding skills in alphabetical languages. These languages differ in phonology, orthography, and how they are mapped for word decoding. However, the literature has debated its role in orthographically consistent languages.

An educational approach using interprofessional (IP) role plays and patient narratives to inculcate empathy and communication among undergraduates in breast cancer management.

Background: Interactive teaching methods such as patient narratives and role plays are effective tools in medical education. Incorporating the patient's perspective of the disease and standardized treatment in the teaching process helps the students become more empathetic and have better doctor-patient communication.

Methods: An interactive module was conducted using role plays and patient narratives to teach communication skills and doctor-patient relationships to randomly chosen Seventy-seven final-year(4th year) medical students to address the various psychosocial problems faced by the patients with breast cancer.

Assessment of early neonatal practices to prevent hypothermia ; A comparative study.

Background: Globally, neonatal deaths are significantly attributed to hypothermia. This is mostly because of its co-morbidity with asphyxia, premature birth and severe neonatal infections. Worldwide, neonatal hypothermia case fatality rates (CFRs) range from 8.

Barriers to Voice Therapy: A Report From Beginners, Performers, and Teachers of Carnatic Music.

Aim: The study aimed to understand awareness, perceptions, and barriers to voice therapy among beginners, performers, and teachers of Carnatic music.

Method: Barriers from the literature were obtained, and the guide for the semistructured interview was developed. Twelve Carnatic singers (four each identified as beginners, performers, and teachers) were contacted and interviewed on an online platform.

A solitary enchondroma in the radial shaft.

Solitary enchondromas are usually seen in the tubular bones of the hands and feet. Their occurrence in the radius is extremely rare. Here, we report a male patient in his 30s with a history of pain in the right forearm for the past 7 months and swelling for the past 4 months.

Needs assessment for interprofessional education module on prevention and early detection of oral cancer among dental interns: a cross- sectional survey.

Background: The challenges associated with ensuring widespread system changes to enable early diagnosis and prevention of oral cancer could benefit from interprofessional practice. A needs assessment study was conducted to inform the Interprofessional Education and Collaborative Practice (IPECP) course related to oral cancer. The primary objectives of this study were 1) to establish a tool assess the knowledge attitude and practice (KAP) related to prevention and early detection of oral cancer of health professional students, and 2) to assess the same KAP of pre-licensure dental students.

Ethanolic extract of leaves alleviates aluminum-induced oxidative stress, lipid peroxidation, and neuroinflammation in rat brain.

Background And Aim: Aluminum (Al)-induced neurotoxicity is known to play a pivotal role in the development of various neurodegenerative diseases, and this is alleged to occur through neuroinflammation and oxidative stress in the brain. This study aimed to determine the effect of a (FR) leaf extract on oxidative stress and neuroinflammation induced by Al exposure in the rat brain by estimating malondialdehyde (MDA), interleukin-6 (IL6), and total antioxidant (TAO) levels along with the degree of neurodegeneration in the brain of AlCl-administered and F leaf extract-treated rats.

Materials And Methods: Two- to three-month-old male albino rats weighing 250-280 g were used in the present study.