14,020 results match your criteria: "Kasımpasa Military Hospital[Affiliation]"

Role of macroscopic on-site evaluation of endoscopic ultrasound-guided fine-needle aspiration/biopsy: Results of a multicentric prospective study.

World J Gastrointest Endosc

November 2024

Department of Gastroenterology and Endoscopy Center, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health, Casablanca 82403, Casablanca-Settat, Morocco.

Article Synopsis
  • The study evaluates the effectiveness of macroscopic on-site evaluation (MOSE) during endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/FNB) in diagnosing solid lesions, particularly focusing on histological core sample adequacy.
  • Conducted across 16 medical centers in Egypt, Iraq, and Morocco, the study involved over 1000 patients and revealed that a significant majority of biopsied samples were adequate for histological evaluation, demonstrating a high diagnostic yield.
  • Results indicated that FNB needles performed best in terms of sensitivity and sample quality, highlighting the potential of MOSE as a valuable alternative to traditional rapid on-site evaluation methods.
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Background: Androgenetic alopecia (AGA) is a multifactorial disorder expressed by several genes and various environmental factors apart from nutritional and endocrinological factors. Although association of iron deficiency (ID) as well as thyroid disorder has been evaluated in females, this is still an untouched topic as far as male pattern hair loss (MPHL) is concerned. This study tries to establish if any association of MPHL with ID and thyroid dysfunction.

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Burn injuries are a constant threat in war. Aspects of the modern battlefield increase the risk of burn injuries and pose challenges for early treatment. The initial resuscitation of a severely burn-injured patient often exceeds the resources available in front-line medical facilities.

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  • - Hashimoto's thyroiditis (HT) is a significant autoimmune thyroid disease where patients often present with asthenia (fatigue), presenting challenges in differentiating it from other conditions; this study aimed to analyze the relationship between HT and asthenia in newly diagnosed patients.
  • - Conducted between July 2022 and July 2023 across multiple university hospitals, the study included 120 patients, divided into an asthenia group (49.2%) and a non-asthenia group, discovering that asthenia was linked to a higher incidence of headaches and hypothyroidism but thyroid function tests were similar between both groups.
  • - The findings suggest that asthenia may not be a strong indicator of thyroid dysfunction
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An ectopic thyroid (ET) involves numerous scenarios of detection and outcomes, while its current management is not standardised. A mediastinal ET (MET) represents a low index of suspicion. In this paper, we introduce a 47-year-old female who was accidentally identified with an MET, and a modern surgical approach was provided.

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  • - The study investigates the effectiveness of different balloon treatments after rotational atherectomy (RA) for calcified coronary lesions, focusing on whether modified balloons (MB) improve outcomes compared to plain balloon angioplasty (BA).
  • - A meta-analysis of nine studies involving 1,024 patients found no significant differences in major adverse cardiovascular events, all-cause mortality, or target lesion revascularization between the RA + BA and RA + MB groups overall.
  • - However, the analysis revealed that for patients with severely calcified lesions, the RA + MB group experienced significantly fewer major adverse cardiovascular events without increasing procedural complications.
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  • The rising incidence of colorectal cancer has emphasized the need for enhanced surgical training, particularly in Poland, where changes to the training program have increased the number of required intestinal procedures for residents.
  • A multicenter study (LILEO study) involving 199 patients aimed to evaluate ileostomy reversal safety, comparing outcomes between surgeries performed by specialist surgeons and those done by surgical residents.
  • Results showed that while the resident group had a shorter hospital stay and a lower overall complication rate, these differences weren't statistically significant; however, minor complications were more prevalent in the specialist group, indicating that resident-performed ileostomy reversals are safe and effective.
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Lyme borreliosis (LB) is more common in the Northern Hemisphere. It is endemic mainly in North America, where the vectors are and , and in Eurasia, where the vectors are and . Both tick-borne diseases and LB are influenced by climate change.

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  • - SGLT2 inhibitors not only help with blood sugar, heart health, and kidney protection but also influence blood pressure, body weight, and fat metabolism.
  • - Blood pressure decreases can vary based on individual health history, with modest drops in body weight (1-2 kg) mainly due to fat loss from excess sugar and calorie loss.
  • - Changes in lipid levels include slight reductions in triglycerides and increases in both HDL and LDL cholesterol, but the exact reasons behind these effects are still being researched.
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  • Amyloidosis is a group of diseases marked by faulty protein deposits that can impair organ function, particularly affecting the gastrointestinal (GI) tract.
  • Recent studies focus on diagnosing and treating GI amyloidosis, particularly from systemic amyloid light-chain (AL) and amyloid A (AA) types, with symptoms potentially including motility issues and severe complications like bowel obstruction.
  • Diagnosing GI amyloidosis relies on endoscopic evaluations and biopsies, but challenges remain due to a lack of targeted therapies and vague symptom presentation.
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Cardiac tumors present substantial diagnostic challenges due to their diverse manifestations and similarity to other cardiac pathologies. Cardiac lipomas are rare tumors that originate from adipose cells and can develop in any location within the heart. Cardiac lipomas account for 2.

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This in vitro study evaluated the sealing ability and microleakage of calcium silicate-based sealers compared to an epoxy resin-based sealer. One hundred twenty-five roots from anterior teeth were chemo-mechanically prepared and divided into four groups: AH Plus (AH), ProRoot MTA (PR), Medcem MTA (MC), and Total Fill BC Sealer/BC-coated gutta-percha (TF); = 30. Confocal laser scanning microscopy was used to measure sealer penetration at three horizontal levels in 10 roots per group, while glucose leakage over 30 days was assessed in 20 roots.

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Cardiovascular diseases (CVD) are a leading cause of death. The most notable cause of CVD is an atherosclerotic plaque. The aim of this review is to provide an overview of different diagnostic methods for atherosclerotic plaque relevant to the assessment of cardiovascular risk.

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Background: Hydatid disease, a parasitic infection caused by the larval form of Echinococcus granulosus, infrequently involves the thyroid gland, whether through direct invasion or hematogenous spread.

Case Presentation: We report the case of a 62-year-old female patient from Morocco who presented with an anterior cervical mass, initially suspected to be a goiter. A histopathological evaluation of the thyroidectomy specimen identified the presence of a hydatid cyst.

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Aim: To determine the rate of prediabetes among and the pre-transplant plasma high-sensitivity C-reactive protein (hs-CRP) value predictive of prediabetes in patients during their first year post-living donor kidney transplant.

Methods: A total of 538 patients underwent living donor kidney transplantation between January 2018 and December 2020, 413 of whom met the inclusion criteria for this study. All patients underwent oral glucose tolerance tests (OGTTs) with 75 g glucose/200 mL solution, starting 3 months post-transplant and repeating the test every 3 months for the first year.

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Pralatrexate represses the resistance of HCC cells to molecular targeted agents via the miRNA-34a/Notch pathway.

Discov Oncol

November 2024

Department of Quality Management, the 967th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army, No. 80 Shengli Road, Xigang District, Dalian, 116021, Liaoning Province, People's Republic of China.

Metabolism-related pathways are important targets for intervention in the treatment of hepatocellular carcinoma (HCC), but few studies have reported on the combination of inhibitors of folate metabolism-related enzymes and molecularly targeted drugs for HCC. The results of the present work are the first to reveal the effects of an inhibitor of dihydrofolate reductase (DHFR), pralatrexate, on the sensitivity of HCC cells to molecularly targeted agents examined using multiple assays. In HCC cells, knockdown of DHFR or treatment with pralatrexate enhanced the sensitivity of HCC cells to molecularly targeted agents, such as sorafenib, regorafenib, lenvatinib, cabozantinib, or anlotinib.

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  • Pancreatic cystic lesions are becoming more common due to improved imaging techniques, necessitating thorough evaluation since some may be cancerous.
  • The study analyzed patients with persistent abdominal pain at a military hospital over six months, leading to 88 cystic lesions identified through endoscopic ultrasound (EUS) and further assessment with fine needle aspiration (EUS-FNA).
  • Results showed that most patients had a history of pancreatitis, with the majority of lesions located in the pancreatic body, primarily involving pancreatic pseudocysts, and all EUS procedures were successfully completed.
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  • Peri orbital hyperpigmentation (POH) is a common skin issue with various causes, and this study aimed to compare the effectiveness of Biofillers vs. Platelet-Rich Plasma (PRP) therapy in treating it.
  • In a double-blinded randomized trial involving 42 patients, the results showed that Biofillers provided significant improvements in pigmentation, patient satisfaction, and had fewer side effects compared to PRP.
  • The study concluded that Biofillers are a more effective and safer treatment option for POH than PRP therapy.
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Background: Medullary thyroid carcinoma (MTC), the third most frequent histological type of thyroid malignancy, may be found isolated or as part of multiple endocrine neoplasia type 2 (MEN2). One particular subtype of this autosomal dominant-transmitted syndrome includes an association with cutaneous lichen amyloidosis, although, generally, a tide genotype-phenotype correlation is described in patients who carry proto-oncogene pathogenic variants.

Methods: Our objective was to provide an endocrine perspective of a case series diagnosed with -positive familial MTC associated with cutaneous primary lichen amyloidosis amid the confirmation of MEN2.

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Background: Thrombophilia, characterized by an increased risk of thrombosis, can result from genetic polymorphisms in clotting factors. This study aims to investigate the prevalence of factor V Leiden (G1691A), factor II prothrombin (G20210A), and MTHFR (C677T and A1298C) polymorphisms in a Greek population, evaluating not only their association with thrombophilia, but also broader health implications.

Methods: We conducted a cross-sectional study involving one hundred apparently healthy adults from Thessaloniki, Greece.

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Introduction: Intestinal ischemia/reperfusion (I/R) injury is associated with high mortality and there is an unmet need for novel therapies. The intestinal expression of cyclooxygenase-2 (COX-2) increases rapidly after mesenteric I/R, but it is still a question of debate whether selective COX-2 inhibitors can mitigate I/R-induced gut injury. Here we aimed to compare the effect of celecoxib and rofecoxib, two selective COX-2 inhibitors, on intestinal I/R-induced injury in rats.

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  • The study focused on how psycho-trauma and perceived social support affect coping strategies in young adults aged 18-28 in Pakistan and Afghanistan, investigating various demographic factors like gender and education.
  • Data was collected from 352 participants using standardized questionnaires, revealing significant negative correlations between psycho-trauma and both perceived social support and problem-focused coping strategies.
  • Gender differences were noted, with men favoring problem-focused coping and women leaning towards emotion-focused coping, while various demographic factors influenced coping mechanisms.
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  • * The text highlights the impact of opioids on fetal brain development, discussing how they disrupt important processes like synaptic plasticity and myelination, which can lead to further developmental challenges.
  • * Treatment options like opioid maintenance therapy (OMT) with methadone and buprenorphine aim to support pregnant women but come with risks, indicating a need for better research and a multidisciplinary approach to manage opioid dependence effectively.
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