151 results match your criteria: "Karpagam University[Affiliation]"
Spectrochim Acta A Mol Biomol Spectrosc
September 2016
Department of Physics, Karpagam University, Eachanari, Coimbatore 641021, TN, India; Research and Development St. Peter's Institute of Higher Education and Research, St. Peter's University, Avadi, Chennai 600054, TN, India.
In this work, the vibrational spectral analysis was carried out by using FT-Raman and FT-IR spectroscopy in the range 4000-50 cm(-1) and 4000-450 cm(-1) respectively for 4-(6-methoxynaphthalen-2-yl) butan-2-one (abbreviated as 4MNBO) molecule. Theoretical calculations were performed by density functional theory (DFT/B3LYP) method using 6-311G(d,p) and 6-311++G(d,p) basis sets. The difference between the observed and calculated wavenumber value of most of the fundamentals were very small.
View Article and Find Full Text PDFOpen Biomed Eng J
April 2015
Faculty of Engineering, Karpagam University, India.
Hypoacusis is the most prevalent sensory disability in the world and consequently, it can lead to impede speech in human beings. One best approach to tackle this issue is to conduct early and effective hearing screening test using Electroencephalogram (EEG). EEG based hearing threshold level determination is most suitable for persons who lack verbal communication and behavioral response to sound stimulation.
View Article and Find Full Text PDFNutr Cancer
February 2016
a Department of Biotechnology , Karpagam University, Coimbatore , Tamilnadu , India.
The plant Plectranthus hadiensis is a rich source of many bioactive phytochemicals, especially terpenoids. The terpenoid fraction was isolated and phytochemical characterization was done using GC-MS. The aim of the present study was to find out the antiproliferative activity and the mechanism of cell death induction by the terpenoid fraction on human colon cancer cells (HCT-15).
View Article and Find Full Text PDFJ Food Sci Technol
February 2015
Hawasaa University, Hawasaa, Ethiopia.
Medicinal plants are at great interest to the researcher in the field of biotechnology, as most of the drug industries depend in medicinal plants for the production of pharmaceutical compounds. Plants are the traditional sources for many chemicals used as pharmaceutical biochemicals, fragrances, food colours and flavours in different countries especially in India. Most herbal medicines and their derivative products were often prepared from crude plant extracts, which comprise a complex mixture of different phytochemical constituents (plant secondary metabolites).
View Article and Find Full Text PDFPharmacognosy Res
January 2015
Department of Biochemistry, Karpagam University, Eachanari, Coimbatore, Tamil Nadu, India ; Department of Bioinformatics, Karpagam University, Eachanari, Coimbatore, Tamil Nadu, India.
Background: Natural products have continually played an important role in drug discovery because it serves as active principles in drugs as well as templates for synthesis of new drugs. Cayratia trifolia (L.) is a medicinal plant, which has been reported to have antiviral, antibacterial, antiprotozoal, hypoglycemic, anticancer and diuretic activities.
View Article and Find Full Text PDF3 Biotech
April 2015
Department of Microbial Biotechnology, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India.
Streptokinase is an extracellular protein secreted by various strains of streptococci and is used clinically as an intravenous thrombolytic agent for the treatment of acute myocardial infarction. It is well established that the fibrinolytic activity of streptokinase originates in its ability to activate plasminogen. The present investigation was carried out to determine the extent of streptokinase production by Streptococcus dysgalactiae subsp.
View Article and Find Full Text PDF3 Biotech
June 2015
Department of Microbial Biotechnology, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India.
Aflatoxin B1 (AFB1) produced by Aspergillus flavus is known to have carcinogenic and teratogenic effects on animal health. Accidental feeding of AFB1-contaminated rice straw may be detrimental to dairy cattle. White-rot basidiomycetous fungus Pleurotus ostreatus can grow on different agronomic wastes by synthesizing different ligninolytic enzymes.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
March 2015
Centre for Research, Department of Physics, AA Government Arts College, Musiri, Tiruchirappalli 621 211, India. Electronic address:
The experimental and theoretical study on the structures and vibrations of 4-hexylacetophenone (abbreviated as 4HAP) are presented. The FT-IR and FT-Raman spectra of the title compound have been recorded in the region 4000-400cm(-1) and 3500-100cm(-1) respectively. The molecular structures, vibrational wavenumbers, infrared intensities and Raman activities were calculated using DFT (B3LYP and LSDA) method with 6-311++G(d,p) basis set.
View Article and Find Full Text PDFChin J Nat Med
November 2014
Department of Biochemistry, College of Medicine & Health Science, Hawassa University, Hawassa, Ethiopia. Electronic address:
Aim: AMany oxidative stress-related diseases occur as a result of the accumulation of free radicals in the body. Free radicals are generated by various endogenous systems, exposure to different physiochemical conditions, or pathological states. A balance between free radicals and antioxidants is necessary for appropriate physiological function.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
February 2015
Department of Physics, Karpagam University, Eachanari, Coimbatore 641021, TN, India; Research and Development St. Peter's Institute of Higher Education and Research, St. Peter's University, Avadi, Chennai 600054, TN, India.
In this work, FT-IR and FT-Raman spectra of 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid (abbreviated as 2DCPAPAA) have been reported in the regions 4000-450cm(-1) and 4000-50cm(-1), respectively. The molecular structure, geometry optimization, intensities, vibrational frequencies were obtained by the ab initio and DFT levels of theory B3LYP with 6-311++G(d,p) standard basis set and a different scaling of the calculated wave numbers. The complete vibrational assignments were performed on the basis of the potential energy distribution (PED) of the vibrational modes calculated using vibrational energy distribution analysis (VEDA 4) program.
View Article and Find Full Text PDFJ Environ Sci (China)
November 2014
Department of Biotechnology, School of Life Sciences, Karpagam University, Coimbatore 641021, Tamil Nadu, India.
Photocatalytic degradation of Bisphenol A (BPA), a representative endocrine disruptor chemical, was carried out under irradiation of sunlight in the presence of CexZn1-xO nanophotocatalyst. Cerium (Ce) ions were successfully incorporated into the bulk lattice of ZnO by simple co-precipitation process. The CexZn1-xO composite nanostructures exhibited higher photocatalytic efficiency than pure ZnO in the degradation of BPA under sunlight irradiation and nearly complete mineralization of BPA was achieved.
View Article and Find Full Text PDFInt Immunopharmacol
December 2014
Department of Biotechnology, School of Biotechnology and Health Sciences, Karunya Institute of Technology and Sciences, Karunya University, Coimbatore 641114, Tamil Nadu, India.
Indigofera caerulea Roxb. is a well known shrub among native medical practitioners in folk medicine used for the treatment of jaundice, epilepsy, night blindness and snake bites. It is also reported to have antioxidant and antimicrobial properties.
View Article and Find Full Text PDFIndian J Hum Genet
April 2014
MedGenome (Division of Molecular Diagnostics), SciGenom Labs Pvt. Ltd, CSEZ, Kakkanad, Cochin, Kerala, India.
Background And Aim: This study reports the prevalence of five clinically significant variants associated with increased risk of cardiovascular disorders, and variable responses of individuals to commonly prescribed cardiovascular drugs in a South Indian population from the state of Kerala.
Materials And Methods: Genomic DNA isolated from 100 out-patient samples from Kerala were sequenced to examine the frequency of clinically relevant polymorphisms in the genes MYBPC3 (cardiomyopathy), SLCO1B1 (statin-induced myopathy), CYP2C9, VKORC1 (response to warfarin) and CYP2C19 (response to clopidogrel).
Results: Our analyses revealed the frequency of a 25 bp deletion variant of MYBPC3 associated with risk of cardiomyopathy was 7%, and the SLCO1B1 "C" allele associated with risk for statin-induced myopathy was 15% in this sample group.
J Food Sci Technol
October 2014
Department of Biotechnology, Karpagam University, Coimbatore, 641 021, Tamil Nadu India.
Caralluma adscendens (Roxb.) Haw var. fimbriata (wall.
View Article and Find Full Text PDFChin J Integr Med
June 2015
Department of Biochemistry, Karpagam University, Coimbatore, 641021, India.
Objective: To identify the free radical scavenging activity of ethanolic extract of Evolvulus alsinoides.
Methods: The free radical scavenging activity was evaluated by in vitro methods like reducing power assay, total antioxidant activity, 2,2-diphenyl-1-picrylhydrazyl (DPPH) reduction, superoxide radical scavenging activity, 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(+)) scavenging activity, hydroxyl radical scavenging assay, and nitric oxide radical scavenging assay, which were studied by using ascorbic acid as standard.
Results: The extract showed significant activities in all antioxidant assays compared with the reference antioxidant ascorbic acid.
Environ Sci Pollut Res Int
February 2015
Molecular Diagnosis and Drug Discovery Laboratory, Department of Biotechnology, School of Life Sciences, Karpagam University, Coimbatore, Tamilnadu, India,
Biomonitoring offers a valuable tool to estimate the genetic risk as of exposure to genotoxic agents. Here, we intend to assess the potential cytogenetic damage related with occupational exposure to polycyclic aromatic hydrocarbons by evaluating the genetic damages in exfoliated buccal epithelial cells of foundry workers via counting micronucleus (MNs) and other nuclear abnormalities (NAs). This was a cross-sectional study and all study subjects were male .
View Article and Find Full Text PDFChin J Integr Med
September 2016
Department of Biochemistry, Karpagam University, Coimbatore, Tamil Nadu, India, 641021.
Objective: To evaluate the enzymatic and non-enzymatic antioxidants of leaf extract from Alpinia purpurata.
Methods: One gram of fresh leaf of Alpinia purpurata was grinded in 2 mL of 50% ethanol and centrifuged at 10,000×g at 4°C for 10 min. The supernatant obtained was used within 4 h for various enzymatic antioxidants assays like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), ascorbate oxidase, peroxidase, polyphenol oxidase (PPO) and non-enzymatic antioxidants such as vitamin C, total reduced glutathione (TRG) and lipid peroxidation (LPO).
Biomed Res Int
May 2015
Department of Biochemistry, Karpagam University, Coimbatore, Tamil Nadu 641021, India ; Department of Bioinformatics, Karpagam University, Coimbatore, Tamil Nadu 641021, India.
This study is an attempt to evaluate the hepatoprotective activity of Tabernaemontana divaricata against DEN and Fe NTA induced liver necrosis in rats. Ethanolic extract of the whole plant of Tabernaemontana divaricata at doses of 200 and 400 mg/kg body weight and 5-fluorouracil (standard drug) was orally administered to male Wistar Albino rats once daily for 24 weeks, simultaneously treated with the carcinogen DEN and Fe NTA. In simultaneously treated animals, the plant extract significantly decreased the levels of uric acid, bilirubin, AST, ALT, and ALP in serum and increased the levels of liver marker enzymes in liver.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
January 2015
Research Department of Physics, Arignar Anna Government Arts College, Musiri, Tiruchirapalli 621211, India. Electronic address:
Experimental FTIR and FT-Raman spectroscopic analysis of 1-Amino-4-methylpiperazine (1A4MP) have been performed. A detailed quantum chemical calculations have been carried out using ab initio HF and density functional theory calculations (B3LYP) with 6-311+G(d,p) basis set. The atomic charges, electronic exchange interaction and charge delocalization of the molecule have been performed by natural bond orbital (NBO) analysis.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
January 2015
Department of Chemistry, Government Arts College, Udumalpet 642 126, Tamil Nadu, India.
Spectroscopic analysis has been carried out to examine the compost quality, maturity and nutritional levels of vermicompost and compost of Eichhornia. 50% Eichhorniacrassipes and 50% cow dung mixtures were vermicomposted using earthworms (Eudrilus eugeniae) and collected on different days' time intervals. Fourier transform infrared spectroscopy (FT-IR) spectra reveal the presence of humic substance from compost and vermicompost, which improves the soil fertility.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
January 2015
Department of Chemistry, University of Antwerp, B2610 Antwerp, Belgium.
6-Methyl-1-({[(2E)-2-methyl-3-phenyl-prop-2-en-1-yl]oxy}methyl)-1,2,3,4-tetra-hydro quinazoline-2,4-dione was prepared via treatment of silylated 6-methylquinazoline-2,4-dione with bis-[(E)-2-methyl-3-phenylallyloxy]methane. FT-IR and FT-Raman spectra were recorded and analyzed. The vibrational wavenumbers were computed using DFT methods and are assigned with the help of potential energy distribution method.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2014
Department of Chemistry, University of Antwerp, B2610 Antwerp, Belgium.
The optimized molecular structure, vibrational frequencies, corresponding vibrational assignments of 5-(Adamantan-1-yl)-3-[(4-fluoroanilino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione are investigated experimentally and theoretically using Gaussian09 software package. Potential energy distribution of normal modes vibrations was done using GAR2PED program. The HOMO and LUMO analysis are used to determine the charge transfer within the molecule.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
November 2014
Department of Biotechnology, School of Life Sciences, Karpagam University, Eachanari Post, Coimbatore, Tamil Nadu, 641 021, India.
The aim of this work is to evaluate the effect of Parthenium-mediated compost on Eudrilus eugeniae during the process of vermicomposting. Nine different concentrations of Parthenium hysterophorus and cow dung mixtures were used to assess toxicity. The earthworms' growth, fecundity and antioxidant enzyme levels were analysed every 15 days.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2014
Faculty of Chemistry, Government Arts College, Udumalpet 642 126, Tamil Nadu, India.
This investigation explains the biosynthesis and characterization of copper oxide nanoparticles from an Indian medicinal plant by an eco-friendly method. The main objective of this study is to synthesize copper oxide nanoparticles from Tabernaemontana divaricate leaves through a green chemistry approach. Highly stable, spherical copper oxide nanoparticles were synthesized by using 50% concentration of Tabernaemontana leaf extract.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
November 2014
Department of Chemistry, University of Antwerp, B2610 Antwerp, Belgium.
The optimized molecular structure, vibrational frequencies, corresponding vibrational assignments of 3-(adamantan-1-yl)-4-(prop-2-en-1-yl)-1H-1,2,4-triazole-5(4H)-thione have been investigated experimentally and theoretically using Gaussian09 software package. Potential energy distribution of normal modes vibrations was done using GAR2PED program. The HOMO and LUMO analysis are used to determine the charge transfer within the molecule.
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