4 results match your criteria: "Karolinska University Huddinge Hospital[Affiliation]"
Insulin and hypoxia-inducible factor-1 cooperate in pancreatic cancer cells to increase cell viability.
Oncol Lett
September 2015
Principal Investigator Unit, Tianjin Institute of Integrative Medicines for Acute Abdominal Diseases, Nankai Hospital, Tianjin 300100, P.R. China ; Department of Surgery, Karolinska University Huddinge Hospital, Huddinge SE-14186, Sweden.
The aim of the present study was to investigate whether interstitial insulin and cancer-induced hypoxia-inducible factor-1 (HIF-1) cooperate in pancreatic cancer cells. A population of 45 nude mice were divided into one intact control group and six pancreatic tumor-carrier groups. Pancreatic tumors were generated using HIF-1-positive wild-type MiaPaCa2 (wt-MiaPaCa2) pancreatic cancer cells in three groups of carriers and MiaPaCa2 cells transfected with small interfering RNA against HIF-1α (si-MiaPaCa2 cells) in the other three carrier groups.
View Article and Find Full Text PDFRandomised clinical trial: transoral incisionless fundoplication vs. sham intervention to control chronic GERD.
Aliment Pharmacol Ther
December 2015
Department of Surgery, Centre for Digestive Diseases, Karolinska University Huddinge Hospital, Karolinska Institutet, Stockholm, Sweden.
Background: Until recently only two therapeutic options have been available to control symptoms and the esophagitis in chronic gastro-oesophageal reflux disease (GERD), i.e. lifelong proton pump inhibitor (PPI) therapy or anti-reflux surgery.
View Article and Find Full Text PDFCell origin in experimental repair of cricoid cartilage defects treated with recombinant human bone morphogenetic protein-2.
Wound Repair Regen
November 2005
Department of Otorhinolaryngology, Karolinska University Huddinge Hospital, Karolinska Institutet, Huddinge, Sweden.
Article Synopsis
- The study focused on identifying the sources of new cartilage and bone formation in rabbit cricoid cartilage defects treated with rhBMP-2.
- New cartilage appeared near the host perichondrium in rhBMP-2-treated rabbits, while new bone was detectable four weeks post-surgery, with early signs of bone development present within a week.
- The findings suggest that new cartilage originates from mesenchymal progenitor cells in the adjacent perichondrium, and new bone may stem from local muscle tissue.
Effect of recombinant human BMP-2 on the repair of cricoid cartilage defects in young and adult rabbits: a comparative study.
Int J Pediatr Otorhinolaryngol
September 2005
Department of Otorhinolaryngology, Karolinska University Huddinge Hospital, Karolinska Institutet, Stockholm, Sweden.
Article Synopsis
- The study examined how cricoid cartilage defects heal in young versus adult rabbits when treated with recombinant human BMP-2.
- Young rabbits showed more elongated cartilage growth and a greater involvement of perichondrium than adult rabbits after treatment.
- Despite age-related differences in cartilage characteristics, both age groups developed new bone with similar features following BMP-2 treatment after 4 weeks.