3,044 results match your criteria: "Karolinska University Hospital Huddinge.[Affiliation]"
J Am Soc Nephrol
October 2024
Department of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Background: Hyponatremia is a common condition with unspecific symptoms and a complicated etiology. The impact of outdoor temperature on hyponatremia is not well-studied and varies depending on the climate and location. This study aimed to investigate the association between outdoor temperature and the prevalence of severe hyponatremia.
View Article and Find Full Text PDFJ Extracell Vesicles
October 2024
Institute of Molecular Biotechnology, Department of Biotechnology, BOKU University, Vienna, Austria.
Extracellular vesicles (EVs) are lipid nanoparticles and play an important role in cell-cell communications, making them potential therapeutic agents and allowing to engineer for targeted drug delivery. The expanding applications of EVs in next generation medicine is still limited by existing tools for scaling standardized EV production, single EV tracing and analytics, and thus provide only a snapshot of tissue-specific EV cargo information. Here, we present the Snorkel-tag, for which we have genetically fused the EV surface marker protein CD81, to a series of tags with an additional transmembrane domain to be displayed on the EV surface, resembling a snorkel.
View Article and Find Full Text PDFEBioMedicine
November 2024
Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:
Sci Transl Med
October 2024
Department of Physiology and Pharmacology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Increased plasma creatine concentrations are associated with the risk of type 2 diabetes, but whether this alteration is associated with or causal for impairments in metabolism remains unexplored. Because skeletal muscle is the main disposal site of both creatine and glucose, we investigated the role of intramuscular creatine metabolism in the pathophysiology of insulin resistance in type 2 diabetes. In men with type 2 diabetes, plasma creatine concentrations were increased, and intramuscular phosphocreatine content was reduced.
View Article and Find Full Text PDFCardiovasc Res
November 2024
Department of Medicine (Huddinge), Karolinska Institutet, ME Endokrinologi, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.
Diabetes Care
December 2024
Karolinska University Hospital and Medical Unit Endocrinology and Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institute, Stockholm, Sweden.
Objective: We assessed the impact of intermittently scanned continuous glucose monitoring (isCGM) compared with blood glucose monitoring (BGM) on rates of hospitalization for metabolic and vascular complications of diabetes and on HbA1c levels for adults with type 1 diabetes.
Research Design And Methods: This retrospective study using data from the Swedish National Diabetes Register and the Swedish National Patient Register comprised adults with type 1 diabetes and an isCGM initiation date after 1 June 2017 and matched control individuals using BGM. Hospital admission rates were calculated per 100 person-years of follow-up.
Clin Kidney J
September 2024
Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.
Background: Creatinine-based equations are the most used to estimate glomerular filtration rate (eGFR). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), the re-expressed Lund-Malmö Revised (r-LMR) and the European Kidney Function Consortium (EKFC) equations are the most validated. The EKFC and r-LMR equations have been suggested to have better performances in young adults, but this is debated.
View Article and Find Full Text PDFEuropace
August 2024
Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Stockholm, Sweden.
Acta Orthop
September 2024
Department of Health, Medicine and Caring Sciences, Unit of Physiotherapy, Linköping University, Linköping; 2 Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Orthopaedics and Biotechnology, Karolinska Institutet, Stockholm; Department of Orthopaedics, Linköping University Hospital, Linköping, Sweden.
Background And Purpose: The study's purpose was to develop and internally validate a prognostic survival model exploring baseline variables for adolescent idiopathic scoliosis curve progression.
Methods: A longitudinal prognostic cohort analysis was performed on trial data (n = 135) including girls and boys, Cobb angle 25-40°, aged 9-17 years, remaining growth > 1 year, and previously untreated. Prognostic outcome was defined as curve progression of Cobb angle of > 6° prior to skeletal maturity.
Cells
August 2024
Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran 16635148, Iran.
In the original publication [...
View Article and Find Full Text PDFBone Marrow Transplant
December 2024
Department of Stem Cell Transplantation, Princess Maxima Centre for Pediatric Oncology, Utrecht, The Netherlands.
Busulfan (Bu) is an important component of many conditioning regimens for allogeneic hematopoietic cell transplantation. The therapeutic window of Bu is well characterized, with strong associations between Bu exposure and the clinical outcome in adults (strongest evidence in myelo-ablative setting) and children (all settings). We provide an overview of the literature on Bu as well as a step-by-step guide to the implementation of Bu therapeutic drug monitoring (TDM).
View Article and Find Full Text PDFN Engl J Med
September 2024
From Respiratory Medicine, Allergology, and Palliative Medicine, Department of Clinical Sciences in Lund, Faculty of Medicine, Lund University, Lund (M.E., F.B.), the Department of Medicine, Blekinge Hospital, Karlskrona (M.E.), the COPD Center, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg (A.A.), and the Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital (S.P.), Gothenburg, Karlstad County Hospital, Karlstad (T.K.), Northern Älvsborg County Hospital, Trollhättan (B.P.), Linköping University Hospital, Linköping (O.K.), Falun Hospital, Falun (P.S.), the Department of Respiratory Medicine and Allergology, Faculty of Medicine, Karolinska University Hospital (M.R.), and Karolinska University Hospital Huddinge (R.H.), Stockholm, the Department of Medical Sciences, Respiratory, Allergy, and Sleep Research, Uppsala University (A.P., E.L., C.J.), and the Uppsala Clinical Research Center (N.H.), Uppsala, the Center for Research and Development, Gävle Hospital, Gävle (A.P.), the Department of Public Health and Clinical Medicine, Umeå University, Umeå (A.B.), Sundsvall-Härnösand County Hospital, Sundsvall (B.S.), and the Department of Respiratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro (J.S.) - all in Sweden; the Institute for Breathing and Sleep and the Department of Respiratory and Sleep Medicine, Austin Health, Melbourne, VIC (C.F.M.), and the Graduate School of Medicine, Faculty of Science, Medicine, and Health, University of Wollongong, Wollongong, NSW (D.C.C.) - both in Australia.
Background: Long-term oxygen supplementation for at least 15 hours per day prolongs survival among patients with severe hypoxemia. On the basis of a nonrandomized comparison, long-term oxygen therapy has been recommended to be used for 24 hours per day, a more burdensome regimen.
Methods: To test the hypothesis that long-term oxygen therapy used for 24 hours per day does not result in a lower risk of hospitalization or death at 1 year than therapy for 15 hours per day, we conducted a multicenter, registry-based, randomized, controlled trial involving patients who were starting oxygen therapy for chronic, severe hypoxemia at rest.
Front Physiol
August 2024
Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Stockholm, Sweden.
Introduction: One way to improve exercise performance and protect heart health is the extended synchronization of the stepping with the diastolic phase of the cardiac cycle. Cardiac-locomotor coupling (CLC) happens when the step rate (SR) equals the heart rate (HR). The extent of CLC in daily life is unknown.
View Article and Find Full Text PDFSci Immunol
September 2024
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize microbial riboflavin pathway metabolites presented by evolutionarily conserved MR1 molecules. We explored the human MAIT cell compartment across organ donor-matched blood, barrier, and lymphoid tissues. MAIT cell population size was donor dependent with distinct tissue compartmentalization patterns and adaptations: Intestinal CD103 resident MAIT cells presented an immunoregulatory CD39CD27 profile, whereas MAIT cells expressing NCAM1/CD56 dominated in the liver and exhibited enhanced effector capacity with elevated response magnitude and polyfunctionality.
View Article and Find Full Text PDFNeurology
October 2024
From the Department of Clinical and Experimental Sciences (B.B.), University of Brescia; Department of Continuity of Care and Frailty (B.B., A.C.A.), ASST Spedali Civili, Brescia; Medical and Genomic Statistics Unit (B.T., M.G.), Department of Brain and Behavioural Sciences, University of Pavia, Italy; Division of Neurogeriatrics (C.G.), Department NVS, Karolinska Institutet, Solna; Unit for Hereditary Dementia (C.G.), Theme Inflammation and Aging, Karolinska University Hospital-Solna, Stockholm, Sweden; Research Unit of Clinical Medicine (J.K., S.A.-S., A.M.P.), Neurology, University of Oulu; MRC (J.K., A.M.P.), Oulu University Hospital; Neurocenter (J.K.), Neurology, Oulu University Hospital, Finland; Department of Neurology (A.C.L., M.O.), University of Ulm; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) (A.C.L.), Ulm, Germany; Cognitive Disorders Unit (F.M., M.B., A.G.), Department of Neurology, Hospital Universitario Donostia; Neuroscience Area (F.M., M.B., A.G.), Biogipuzkoa Health Research Institute, San Sebastian, Spain; Department of Neurology (M.O.), Martin Luther University, University Hospital, Halle (Saale), Germany; MRC Cognition and Brain Sciences Unit (J.B.R., A.G.M., T.R.), Department of Clinical Neurosciences, and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, United Kingdom; Department of Neurology and Alzheimer Center Erasmus MC (H.S., E.V.D.E., J.C.V.S.), Erasmus MC University Medical Center, Rotterdam, the Netherlands; Neurology (E. Solje, P.H.), Institute of Clinical Medicine, University of Eastern Finland; Neurocenter (E. Solje), Neurology, Kuopio University Hospital, Finland; Neurology Clinic (E. Stefanova, G.M.S.), Faculty of Medicine, University Clinical Center, University of Belgrade; UH Alexandrovska (L.D.T., S.M.), Department of Neurology, Medical University Sofia, Bulgaria; Theme Inflammation and Aging (V.J.), Medical Unit Aging Brain, Karolinska University Hospital Huddinge, Solna; Division of Clinical Geriatrics (V.J.), Department NVS, Karolinska Institutet, Huddinge, Sweden; Molecular Markers Laboratory (R.G.), IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia; and Center for Neurodegenerative Diseases and the Aging Brain (M.T.D., C.Z., G.L.), Pia Fondazione Cardinale Giovanni Panico, University of Bari-Aldo Moro, Italy.
Background And Objectives: Data on care home admission and survival rates of patients with syndromes associated with frontotemporal lobar degeneration (FTLD) are limited. However, their estimation is essential to plan trials and assess the efficacy of intervention. Population-based registers provide unique samples for this estimate.
View Article and Find Full Text PDFBone Marrow Transplant
December 2024
Dept. of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska Comprehensive Cancer Center, Karolinska University Hospital Huddinge, Div. of Hematology, Dept. of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
The aim of this prospective, international multicenter, pseudorandomized study comparing RICT HCT to standard-of-care chemotherapy in intermediate- or high-risk AML patients 50-70 years using the donor versus no-donor concept. Part 1 included only patients with potential family donors (RD) at the date of HLA-typing of the first potential sibling or CR-date, if later. Part 2 allowed the inclusion of patients without a possible sibling donor using the start of an unrelated donor (URD) search as inclusion date.
View Article and Find Full Text PDFCirculation
December 2024
Karolinska Institutet, Department of Clinical Sciences, Division of Cardiovascular Medicine, Danderyd University Hospital, Stockholm, Sweden (K.K.G., L.F., T.H., V.F., F.A.-K., M.R., J.E.).
Background: Guidelines have suggested screening for atrial fibrillation to enable early treatment and avoid downstream negative clinical events. We aimed to determine whether atrial fibrillation screening potentially enhanced by NT-proBNP (N-terminal pro-B-type natriuretic peptide) would reduce stroke or systemic embolism incidence compared with a control group and to determine whether it was safe for those with low NT-proBNP concentrations to forfeit prolonged screening.
Methods: In this randomized controlled trial, all 75- and 76-year-old individuals in Stockholm Region, Sweden, were randomized 1:1 to be invited to screening or serve as a control group.
J Allergy Clin Immunol Pract
December 2024
Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, Mich.
Heart Rhythm
October 2024
Karolinska Institutet, Department of Medicine Huddinge, Karolinska University Hospital Huddinge, Stockholm, Sweden.
J Cyst Fibros
September 2024
Department of Respirology, St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address:
Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).
Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021.
Cell Res
August 2024
Department of Cell and Molecular Biology and Department of Medicine Huddinge, Center for Hematology and Regenerative Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, Sweden.
Int J Cancer
January 2025
Center for Cervical Cancer Elimination, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
In well-screened populations, most cervical cancers arise from small groups of women with inadequate screening. The present study aims to assess whether registry-based cancer risk assessment could be used to increase screening intensity among high-risk women. The National Cervical Screening Registry identified the 28,689 women residents in Sweden who had either no previous cervical screening or a screening history indicating high risk.
View Article and Find Full Text PDFHemasphere
August 2024
Applied Tumor Genomics Research Program, Research Programs Unit, Faculty of Medicine University of Helsinki Helsinki Finland.
Increasing recognition of germline variants in patients with hematological malignancies prompted us to provide -specific recommendations for diagnosis, surveillance, and treatment. Causative germline variants in the predispose to the development of myeloid neoplasms (MNs), especially myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Almost 3%-5% of all patients with MDS or AML carry a pathogenic or likely pathogenic germline variant, while half of them acquire a somatic second hit in the other allele.
View Article and Find Full Text PDFAge Ageing
August 2024
Department of Geriatric Medicine, Faculty of Medicine/Clinical Medicine, University of Turku and Turku University Hospital, The wellbeing services county of Southwest Finland, Turku, Finland.
Introduction: Due to the increasing number of older patients in emergency departments (EDs) with frailty, cognitive impairment and multimorbidity, there is a need for geriatric expertise in EDs.
Methods: This retrospective study is of older patients visiting Turku University Hospital ED between 2 January and 31 December 2022. Patients aged 75 years of older were screened for frailty using Triage Risk Screening Tool (TRST) and Clinical Frailty Scale (CFS).