Exploration of health care utilization, social care utilization and costs for individuals discharged from inpatient geriatric care in Sweden - a registry data study.

Background: Individuals receiving geriatric care are often frail and afflicted with multiple chronic conditions demanding care from several medical disciplines, and from several different care providing units across the health systems.

Objective: To explore the six-month service utilization and direct costs attributed to individuals receiving geriatric inpatient care.

Methods: Health care utilization- in terms of inpatient care, outpatient visits with different health care professions- and social care utilization- in terms of social services, and stay at residential care facility (RCF)- were quantified based on registry data, for a cohort admitted to geriatric inpatient care in Stockholm, Sweden during 2016.

Characterizing Heart Failure Across the Spectrum of the Preserved Ejection Fraction: Does Heart Failure With Supranormal Ejection Fraction Exist? Data From the Swedish Heart Failure Registry.

Background: Sparce data suggest higher mortality in heart failure (HF) with left ventricular ejection fraction (EF) >65% to 70%. We characterized EF distribution, characteristics, and outcomes in patients with HF and EF ≥50%.

Methods And Results: There were 5576 patients enrolled in the Swedish HF registry between 2017 and 2021 and included in the study; 21% had EF ≥60%, 5% EF ≥65%, and 1.

Midlife financial stress and cognitive and physical impairments in older age: The role of potentially modifying factors.

Background: Financial stress is an important source of chronic stress and has been associated with cognitive and physical impairments. The goal of this study was to investigate whether financial stress is associated with cognitive and physical impairment and their combination, the role of potential modifiable factors and potential sex differences.

Methods: The Cardiovascular Risk Factors, Aging, and Dementia population-based cohort study from Finland was used (n = 1497) (baseline data collected 1972-1987, mean age 50 years).

"I'm a bit more free": Lived symptom experiences in adolescents with functional abdominal pain disorders after internet-delivered psychological treatment.

Studies of internet-delivered cognitive behavioral therapy (ICBT) have documented its efficacy for pediatric Functional Abdominal Pain Disorders (FAPDs), but few have detailed how adolescents experience this. We investigated the lived symptom experiences of eight adolescents (age 13-17 years) with FAPDs, who had received ICBT. Semi-structured interviews were conducted using photo-elicitation, and analyzed using Interpretative Phenomenological Analysis, identifying three main themes; "Power of thoughts" describes the impact of thoughts on understanding symptoms and self.

Genetic liability for anxiety and treatment response to the monoamine stabilizer OSU6162 in alcohol dependence: a retrospective secondary analysis.

Background: OSU6162, a monoamine stabilizer, has demonstrated efficacy in reducing alcohol and anxiety-related behaviors in preclinical settings. In a previous randomized, double-blind, placebo-controlled trial involving patients with alcohol dependence (AD), OSU6162 significantly reduced craving for alcohol but did not alter drinking behaviors. This retrospective secondary analysis explores whether genetic predispositions related to AD and associated traits might influence the response to OSU6162 treatment in original trial participants.

Single-stage ACL reconstruction and displaced bucket handle Meniscus repair is associated with lower Meniscus repair failure rates compared to two-stage surgery.

Purpose: To compare displaced bucket-handle meniscus repair (BHMR) failure rates, subjective and objective knee function after BHMR in the setting of ACLR performed as a single-or two-stage procedure, and assess factors associated with BHMR survival.

Methods: This retrospective study included patients who underwent surgery between February 2015 and December 2021 at one institution. Patients with a displaced bucket-handle meniscus tear (BHMT) and ACL-injury undergoing BHMR and ACLR as a single- (concomitant BHMR and ACLR) or two-stage (BHMR and subsequent ACLR) procedure were identified.

γδ T cell characterisation in the long term after haematopoietic stem cell transplantation and its impact on CMV control and cGVHD severity.

Objectives: The clinical outcome after allogeneic haematopoietic stem cell transplantation (aHCT) relies greatly on the efficient recovery of T cells. Several studies have investigated the short-term γδ T cell reconstitution and their role in clinical outcomes following haematopoietic stem cell transplantation. Nevertheless, their long-term characteristics and impact have remained largely unknown.

Antisocial and prosocial behaviors as predictors of subsequent substance use in adolescence.

Background: Antisocial behavior is a known risk factor for substance use in adolescence, but the combined effects of antisocial and prosocial behaviors are unknown. This study examined whether five types of anti- and prosocial behaviors are associated with subsequent alcohol and substance use.

Methods: A prospective longitudinal cohort study of 3817 adolescents (55.

Decreased levels and function of dendritic cells in blood and airways predict COVID-19 severity.

Objectives: Monocytes and dendritic cells (DCs) are essential players in the immune response to infections, involved in shaping innate and adaptive immunity. However, a complete understanding of their specific roles in respiratory infections, including SARS-CoV-2, remains elusive.

Methods: To investigate the dynamics of monocytes and DCs in blood as well as the upper and lower airways, we sampled 147 patients with varying degree of COVID-19 severity longitudinally during the spring of 2020.

Different sensory dimensions in infancy are associated with separable etiological influences and with autistic traits in toddlerhood.

Background: Infants vary significantly in the way they process and respond to sensory stimuli, and altered sensory processing has been reported among infants later diagnosed with autism. Previous work with adolescents and adults suggests that variability in sensory processing may have a strong genetic basis. Yet, little is known about the etiological factors influencing sensory differences in infancy, when brain circuits supporting social and non-social cognition are sculpted and learning about the world via sensory input largely occurs in interaction with caregivers.

Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis.

Background: Autistic individuals often receive psychiatric diagnoses prior to their autism diagnosis. It remains unclear to what extent autistic females and males differ in their likelihood of receiving psychiatric diagnoses prior to their autism diagnosis and continue seeking care for them after an autism diagnosis.

Methods: In a nationwide cohort of all individuals born in Sweden 1990-2015 with a clinical autism diagnosis (N = 72,331, n = 24,110), we used linear and logistic regression to estimate the association between sex and (a) psychiatric diagnoses before autism diagnosis, including time trends by autism diagnosis year (2010-2020), (b) autism diagnosis age in those with preceding diagnoses, (c) stability of preceding diagnoses (defined as continued care utilization indicated through diagnosis or medication in the 5 years following autism diagnosis).

Readmission After Geriatric Inpatient Care: A Narrative Review and a Comparative Analysis.

Background: Readmission can be be related to the work of several stakeholders involved in the care of individuals throughout the community, including, for example, primary care and social care providers. A narrative review was performed to assess definitions and frequency of readmission for older adults found in previous research. In addition, a dataset for a cohort of older adults in Stockholm, Sweden, was used to quantify how different definitions of readmission affect frequency.

Gene expression of calcium transporters Calbindin-D28K and TRPV6 in Japanese quails (Coturnix japonica) subjected to phytase super-dosing and under different temperatures.

This study aimed to evaluate the effects of phytase super-dosing in the diet of laying quails subjected to different temperatures, their performance, blood biochemistry, and gene expression of the epithelial calcium transporters Calbindin-D28 K and TRPV6. Seven hundred and twenty (720) Japanese quails in the production phase were distributed in a completely randomized design, in a 5 × 3 factorial scheme, with five levels of phytase supplementation (0, 500, 1000, 1500 and 3000 FTU/kg) and three temperatures (24°C, 30°C and 36°C), totaling 15 treatments, and six replicates of eight birds each. The study began at 8 weeks of age and continued for two 21-day cycles, totaling 42 days of experiment.

Person-centered care at population scale: The Swedish registry for behavioral and psychological symptoms of dementia.

Introduction: Behavioral and psychological symptoms of dementia (BPSD) are a common driver of suffering and high care needs. We describe the Swedish BPSD registry, founded in 2010 to develop an evidence base for quality improvement in the care of patients with BPSD. Further, we illustrate the potential of the registry by evaluating how individual BPSD affects mortality.

Efficacy and mediators of online cognitive therapy for taboo obsessions in adults with obsessive-compulsive disorder: Randomized controlled trial.

Taboo obsessions are ego-dystonic, recurrent, and intrusive thoughts involving aggressive, sexual and/or religious themes, which are common in individuals with obsessive-compulsive disorder (OCD). These symptoms are often challenging to treat with traditional, exposure-based approaches. Our research group has developed and successfully piloted an Internet-delivered intervention based on the cognitive framework of taboo obsessions (I-CT).

Effectiveness of ultra-rapid (20 min) high-frequency in-situ cardiac arrest simulations in a high-volume operating department - A tool for evaluating and implementing emergency routines.

Background: In-situ simulations are effective in identifying latent safety threats. In high-volume elective operating departments, cardiac arrests are rare due to strict patient selection. Implementing in-situ cardiac arrest simulations in these settings is crucial to evaluate adherence to cardiopulmonary resuscitation (CPR) guidelines and enhance patient safety by detecting and managing safety threats.

Development and internal validation of a risk prediction model for dementia in a rural older population in China.

Introduction: We sought to develop a practical tool for predicting dementia risk among rural-dwelling Chinese older adults.

Methods: This cohort study included 2220 rural older adults (age ≥ 65 years) who were dementia-free at baseline (2014) and were followed in 2018. Dementia was diagnosed following the DSM-IV criteria.

Mandatory verses voluntary self-tests for new online casino customers: effect on engagement, quality, gambling behavior and use of responsible gambling measures.

Background: To combat the public health concern that is problem gambling, gambling operators are increasingly being required by legislation to exercise a duty of care obligation, including the provision of Responsible Gambling (RG) tools. Self-test assessments have long been a popular RG tool implemented by many operators, yet there has been scant empirical research on self-tests, including on how the method of delivery impacts engagement, quality, and subsequent gambling behavior. The main objective of the current study was to examine if the level of voluntariness to perform a self-test moderated these key outcomes.

Shared Environment - Different Genes: Speech-Language Development in a Pair of Dizygotic Twins with and Without Mutation.

This retrospective study compared the speech-language development of a pair of dizygotic twin girls during the first 2 years of life: one with typical development (Twin A) and one with atypical development (Twin B), who was later diagnosed with Rett syndrome (RTT). Audio snippets were extracted from home videos, with nearly equal representation from each child. The audio analysis focused on articulatory complexity, voice characteristics, and linguistic variability.

Individual differences in treatment effects of internet-based cognitive behavioral therapy in primary care: a moderation analysis of a randomized clinical trial.

Background And Aims: Little is known regarding predictors of outcome in treatment of alcohol dependence via the internet and in primary care. The aim of the present study was to investigate the role of socio-demographic and clinical factors for outcomes in internet-based cognitive behavioral treatment (ICBT) added to treatment as usual (TAU) for alcohol dependence in primary care.

Design: Secondary analyses based on data from a randomized controlled trial in which participants were randomized to ICBT + TAU or to TAU only.

Quantity and quality of social relationships and their associations with loneliness in older adults.

Objectives: Loneliness arises from a discrepancy between the relationships one desires and those one experiences. This study examines the relative importance of relationship quantity and quality for loneliness in older adults.

Method: The study was a cross-sectional, representative survey of 474 adults aged 77 and above living in Dalarna, Sweden.

Atypical Resting-State EEG Graph Metrics of Network Efficiency Across Development in Autism and Their Association with Social Cognition: Results from the LEAP Study.

Autism has been associated with differences in functional brain network organization. However, the exact nature of these differences across development compared to non-autistic individuals and their relationship to autism-related social cognition, remains unclear. This study first aimed to identify EEG resting-state network characteristics in autistic versus non-autistic children, adolescents, and adults.

Both childhood and adult perceived financial strain impact age trajectories of change in emotional health in late adulthood.

Objectives: Socioeconomic status impacts emotional health outcomes, but a lifecourse approach is necessary to understand the timing of these effects. The current analyses examined the impact of financial strain in childhood and adulthood on longitudinal changes in three measures of emotional health: depressive symptoms, loneliness, and anxiety.

Method: Data were from 1596 adults from the Swedish Twin Registry, aged 45 to 98 at intake (mean = 72.