Clinical and neurophysiological evaluation of persistent sensory disturbances in breast cancer women after mastectomy with or without radiotherapy.

Purpose: Breast cancer surgery or radiotherapy (RT) are potential causes of persistent pain syndrome. It remains to be clarified whether numbness or pain reported by patients after mastectomy and RT are conditioned by changes in nerve transmission. The aim of this study was to examine the potential relationship between subjective sensory complications and neurophysiological examinations in breast cancer survivors with post-mastectomy pain syndrome.

The influence of passive and active moral training on medical university on changes of students' moral competence index - results from randomized single blinded trial.

Introduction And Objectives: Human's life as well as medical professions consist of many moral dilemmas. The aim of our study was to evaluate moral competences of midwifery students during their whole university education (3 year course) based on their moral competences C-index.

Material And Method: We performed randomized single blinded 3-year follow-up trial of 72 midwifery students.

Development of antiangiogenic therapies for ovarian cancer.

Angiogenesis is a dynamic process which leads to a development of cancer and metastases. The most recognized and dominant prognostic factor is vascular endothelial growth factor (VEGF) and its receptors. VEGF was identyfied in 1989.

Massive bleeeding from upper gastrointestinal tract as a symptom of rupture of splenic artery aneurysm to stomach.

Background: Splenic artery aneurysm is the most common aneurysm of visceral vessels. Their rupture usually leads to massive bleeding, being a direct life threat. Splenic artery aneurysms usually rupture into the free peritoneal cavity, and much less frequently into the lumen of the gastrointestinal tract.

Prevalence of selected risk factors for cardiovascular diseases in adolescents with overweight and obesity.

Aim Of The Study: The aim of the study was to assess the prevalence of elevated blood pressure values and significant family history with respect to the incidence of cardiovascular diseases in overweight and obese adolescents.

Material And Methods: Our study encompassed 4904 adolescents from randomly selected schools from the Wielkopolska province of Poland. Measurements of body height and mass were performed in all the school pupils.

Evaluation of the antihypertensive effect of L-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring.

Background: Arterial hypertension is one of the most important cardiovascular risk factors, featuring the unsatisfactory efficacy of current therapies. The cardiovascular disease paradigm which assumes a crucial role of the endothelial phenotype in shaping the state of the circulatory system has become increasingly dominant and endothelial dysfunction should be treated as avidly as the diseases of other organs. The most valued current anti-hypertensive therapies exert a positive influence on the endothelium due to their pleiotropic effects, but the search for new effective strategies aimed at improving endothelial function is underway.

Global DNA methylation changes in blood of patients with essential hypertension.

Background: Hypertension is a common disease of the cardiovascular system and one of the main causes of mortality in the world. Its etiopathogenesis and molecular mechanisms are unknown. Epigenetic changes may play a role in its development.

[Psychological view of thyroid cancer and in hyperthyroid Graves' patients - comparative exploration].

Introduction: The aim of study was the evaluation of association between psychometric factors in patients with thyroid cancer and in Graves' hyperthyroid patients.

Material And Methods: We examined 50 patients with differentiated thyroid cancer, 42 females (84.75%), 8 males aged from 32 to 64 yr.

The landscape after PEACE: do all ACE inhibitors act in an identical way?

The results of the Prevention of Events with Angiotensin Converting Enzyme Inhibition (PEACE trial), involving patients with stable coronary heart disease, demonstrated that the angiotensin-converting enzyme (ACE) inhibitor trandolapril did not reduce cardiovascular mortality, or the incidence of fatal or non-fatal myocardial infarction. These results were in conflict with the vast majority of previously published large-scale trials, and could be seen to weaken confidence in ACE inhibitor therapy of ischaemic heart disease. This review article examines the results of PEACE in comparison with the other major trials in terms of the severity of the disease in the patients, the statistical power of the analyses, the doses of the agents used and the concept of a 'class effect' of the ACE inhibitors.

Human chorionic gonadotropin-beta in endometrium cancer tissue.

Purpose: Determination of the correlation between expression of human chorionic gonadotropin mRNA and serum free hCGb immunoreactivity in endometrial cancer tissue.

Methods: The study included 56 patients with endometrial carcinoma Stages IB-III. The expression of mRNA hCGbeta was determined by the RT PCR method in 18 cases of cancerous and precancerous tissues.

Results of repair of partial anomalous pulmonary venous connection and sinus venosus atrial septal defect in adults.

Background And Aims Of The Study: This retrospective study evaluated late results of surgical treatment of partial anomalous pulmonary venous connection (PAPVC) concomitant with sinus venosus-type atrial septal defect (ASD) with the use of pericardial patch technique.

Methods: Between 1981 and 1995, 25 consecutive patients (18 females, seven males) underwent surgical repair of PAVPC with ASD. Mean age at surgery was 37.

Fine structure of the capillaries in the spinal cord of human embryos at 7th week.

Study were made in three human embryos at developmental stages 18 and 19 (7th week). It was shown that the wall of the capillaries is formed by one or two endothelial cells, which are separated by perivascular space from the glial cells. Endothelial cells possessed cilia projecting into the vascular lumen and are connected through the zonulae occludentes.

Low molecular weight heparin and the heparin mobilisable pool of platelet factor 4 are reduced in young survivors of myocardial infarction.

The platelet factor 4 (PF4) mobilisation properties of low molecular weight heparin (Fraxiparine, Sanofi Winthrop, France) in young survivors of myocardial infarction (YSMI) and healthy volunteers have been investigated. The study group consisted of 42 YSMI less than 44 years old, all of them with angiographically proven occlusive coronary artery disease, studied 6 to 24 months after the acute event. The control group was composed of 30 healthy men of similar age.

Effective peritoneal capillary blood flow and peritoneal transfer parameters.

In uremic patients peritoneal transfer was evaluated at 0-45-minute dwells in exchanges 3-5,9-11, and 15 -17 of single intermittent peritoneal dialysis (IPD) and compared to effective peritoneal blood flow (EPBF) simultaneously estimated as KBD for CO2 gas using the two-sample model of Garred et al. for a 2.5-minute dwell.