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Factors associated with experience of fatigue, and functional limitations due to fatigue in patients with stable COPD.
Ther Adv Respir Dis
October 2016
Faculty of Health, Science and Technology, Department of Health Sciences, Nursing, Karlstad University and Primary Care Research Unit, County Council of Värmland, Karlstad, Sweden.
Background: The aim of this study was to determine the influence of selected physiological, psychological and situational factors on experience of fatigue, and functional limitations due to fatigue in patients with stable chronic obstructive pulmonary disease (COPD).
Methods: In total 101 patients with COPD and 34 control patients were assessed for experience of fatigue, functional limitation due to fatigue (Fatigue Impact Scale), physiological [lung function, 6-minute walk distance (6MWD), body mass index (BMI), dyspnoea, interleukin (IL)-6, IL-8, high sensitivity C-reactive protein (hs-CRP), surfactant protein D], psychological (anxiety, depression, insomnia), situational variables (age, sex, smoking, living alone, education), and quality of life.
Results: Fatigue was more common in patients with COPD than in control patients (72% versus 56%, p < 0.