Sharing for Caring? A Patients' and Clinicians' View on Handling Personal Medical Data in the Context of Digitization: An Exploratory Study.

Background: The healthcare sector is currently undergoing a significant transformation, driven by an increased utilization of data. In this evolving landscape, surveys are of pivotal importance to the comprehension of patient needs and preferences. Moreover, the digital affinity of patients and physicians within the healthcare system is reforming the manner in which healthcare services are accessed and delivered.

Anomalous frozen evanescent phonons.

Evanescent Bloch waves are eigensolutions of spatially periodic problems for complex-valued wavenumbers at finite frequencies, corresponding to solutions that oscillate in time and space and that exponentially decay in space. Such evanescent waves are ubiquitous in optics, plasmonics, elasticity, and acoustics. In the limit of zero frequency, the wave "freezes" in time.

HoLLiECares - Development of a multi-functional robot for professional care.

Germany's healthcare sector suffers from a shortage of nursing staff, and robotic solutions are being explored as a means to provide quality care. While many robotic systems have already been established in various medical fields (e.g.

Environmental impact of an anthropogenic groundwater temperature hotspot.

Heat emitted by buildings and other infrastructure accumulates in the subsurface. This additional heat can cause a pronounced shift in thermal boundary conditions of the important groundwater ecosystem. Shallow groundwater systems in Central Europe are often inhabited by communities of fauna adapted to cold and stable conditions as well as microorganisms, whose activity is dependent on ambient temperatures.

Perspectives on NO Emissions and Impacts from Ammonia Combustion Processes.

Climate change and global warming necessitate the shift toward low-emission, carbon-free fuels. Although hydrogen boasts zero carbon content and high performance, its utilization is impeded by the complexities and costs involved in liquefaction, preservation, and transportation. Ammonia has emerged as a viable alternative that offers potential as a renewable energy storage medium and supports the global economy's decarbonization.

Lattice Dynamics of CuZnSn(S ,Se ) Kesterite Thin-Film Solar Cells Studied by Nuclear Inelastic Scattering.

Phonons play a crucial role in thermalization and non-radiative recombination losses in semiconductors, impacting the power conversion efficiency of solar cells. To shed light on the lattice dynamics in CuZnSn(S ,Se ) (CZTSSe) thin-film solar cells and validate the extensive number of theoretical studies, we determine the Sn-partial phonon density of states (Sn-PDOS) by nuclear inelastic X-ray scattering. CZTSSe-based devices, one with near-stoichiometric and two with off-stoichiometric compositions, are investigated, and the results are correlated with the corresponding power conversion efficiencies (PCEs) of 3.

Alginate-modified graphene oxide anchored with lactoperoxidase as a novel bioactive nanocombination for colorectal cancer therapy.

It is imperative to explore new biocompatible drugs with low toxicity for use in medicinal fields such as fighting tumors. Bovine lactoperoxidase (BLPO) stems from the most important enzymes in the bovine whey that provide a proper pattern for nano-formulation with nanomaterials. LPO is a suitable protein to be coated or adsorbed to alginate modified graphene oxide (GO-SA), which forms the modified GO-SA-LPO hybrid structure.

Protein composition and bread volume of German common wheat landraces grown under organic conditions.

Landraces are genetically heterogeneous plant populations that are regionally particularly well adapted to the natural and cultural agricultural environment. Their genetic memory originates from pre-industrial agriculture and food production with consequences for their agronomic and processing performance. Since wheat-related disorders have increased in the population, breeding might have resulted in changes in the protein composition.

Effective removal of host cell-derived nucleic acids bound to hepatitis B core antigen virus-like particles by heparin chromatography.

Virus-like particles (VLPs) show considerable potential for a wide array of therapeutic applications, spanning from vaccines targeting infectious diseases to applications in cancer immunotherapy and drug delivery. In the context of hepatitis B core antigen (HBcAg) VLPs, a promising candidate for gene delivery approaches, the naturally occurring nucleic acid (NA) binding region is commonly utilized for effective binding of various types of therapeutic nucleic acids (NA). During formation of the HBcAg VLPs, host cell-derived nucleic acids (NA) might be associated to the NA binding region, and are thus encapsulated into the VLPs.

Investigating the effect of overbased sulfonates on calcium sulfonate complex grease: enhancements in physicochemical, rheological, and tribological properties.

Overbased sulfonate plays a crucial role in calcium sulfonate complex grease, significantly impacting the grease's performance characteristics. Herein, the calcium sulfonate complex grease was formulated using overbased calcium sulfonate (T106D) and overbased magnesium sulfonate (T107) in ratios of 1 : 2, 1 : 1, and 2 : 1, labeled as CMSCG (1 : 2), CMSCG (1 : 1), and CMSCG (2 : 1), respectively. This study examined the effects of overbased sulfonates on the physicochemical, anti-corrosion, rheological, and tribological properties of the grease.

Drug retention after intradiscal administration.

Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding their connection will enable the optimization of IVDD therapeutics.

A Critical View on the Use of DNA Hydrogels in Cell-Free Protein Synthesis.

Numerous studies have reported in the past that the use of protein-encoding DNA hydrogels as templates for cell-free protein synthesis (CFPS) leads to better yields than the use of conventional templates such as plasmids or PCR fragments. Systematic investigation of different types of bulk materials from pure DNA hydrogels and DNA hydrogel composites using a commercially available CFPS kit showed no evidence of improved expression efficiency. However, protein-coding DNA hydrogels were advantageously used in microfluidic reactors as immobilized templates for repetitive protein production, suggesting that DNA-based materials offer potential for future developments in high-throughput profiling or rapid in situ characterization of proteins.

Ion chromatography coupled with optical emission spectrometry (IC-ICP-OES) methodology for the analysis of inositol phosphates in food and feed.

This study presents the development of ion chromatography coupled with inductively coupled plasma optical emission spectrometry (IC-ICP-OES) for the simultaneous determination and quantification of inositol phosphates (InsP). Using a CarboPac PA100 column with a nitric acid-water gradient, 28 InsP isomers (InsP to InsP) were separated within 33 min. The method eliminates baseline drift and post-column derivatization thereby simplifying detection and quantification.

Simultaneous multinuclear MRI via a single RF channel.

Magnetic resonance imaging (MRI) stands as one of the most powerful noninvasive and non-destructive imaging techniques, finding extensive utility in medical and industrial applications. Its ability to acquire signals from multiple nuclei grants it additional levels of strength by providing multi-dimensional datasets of the object under test. However, this typically requires dedicated hardware to detect each nucleus.

Modulating the photolysis of aryl azides in a supramolecular host to develop photoactivatable fluorophores.

Photolysis of aryl azides is a convenient method to approach more functionalized systems in chemical biology. Here, we present a set of photoactivatable aryl azides that undergo controlled reaction pathways within the cucurbit[7]uril (CB7) cavity upon photolysis. The fluorescence turn-on process is utilized for bioimaging.

A simple method to modulate the selectivity of aryl azide photolysis using cucurbit[8]uril.

Photolysis of aryl azides typically involves multiple reaction pathways. This study designed and synthesized an aryl azide rotamer with two conformations. In aqueous media, its photolysis yields two main products.

Indole Derivatives: A Versatile Scaffold in Modern Drug Discovery-An Updated Review on Their Multifaceted Therapeutic Applications (2020-2024).

Indole derivatives have become an important class of compounds in medicinal chemistry, recognized for their wide-ranging biological activities and therapeutic potential. This review provides a comprehensive overview of recent advances in the evaluation of indole-based compounds in the last five years, highlighting their roles in cancer treatment, infectious disease management, anti-inflammatory therapies, metabolic disorder interventions, and neurodegenerative disease management. Indole derivatives have shown significant efficacy in targeting diverse biological pathways, making them valuable scaffolds in designing new drugs.

Electrode Droplet Microarray (eDMA): An Impedance Platform for Label-Free Parallel Monitoring of Cellular Drug Response in Nanoliter Droplets.

Label-free real-time monitoring of cellular behavior using impedance spectroscopy is important for drug development and toxicological assessments. Parallelization and miniaturization of such experiments are essential for increasing throughput and enabling experiments with low abundant stem or primary cells. Traditional methods are not miniaturized and require large volumes of reagents and number of cells, limiting their suitability for cost effective high-throughput screening of cells of limited availability.

Revealing Intrinsic Functionalization, Structure, and Photo-Thermal Oxidation in Hexagonal Antimonene.

Antimonene is one of the more exciting members of the post-graphene family with promising applications in optoelectronics, energy storage and conversion, catalysis, sensing or biomedicine. Efforts have been focused on developing a large-scale production route, and indeed, through a colloidal approach, high-quality few-layers antimonene (FLA) hexagons have been recently obtained. However, their oxidation behavior remains unexplored, as well as their interface, inner structure, and photothermal properties.