986 results match your criteria: "Karl-Landsteiner University of Health Sciences[Affiliation]"
The Artisse intrasaccular device for the treatment of cerebral aneurysms: initial experience from three Austrian neurovascular centers.
J Neurointerv Surg
January 2025
Institute of Neurointervention, Paracelsus Medical University, Salzburg, Austria.
Background And Purpose: This study evaluates the early clinical performance of the new Artisse Intrasaccular Device (Artisse ISD), a self-expandable intrasaccular flow diverter, for treating wide-necked aneurysms (WNAs). We report initial safety and efficacy outcomes in the first cohort of patients treated with this novel device.
Methods: Prospective clinical and radiological data were collected for all patients treated with the Artisse ISD at three Austrian neurovascular centers from July 2023 to August 2024.
Transcriptomic Profiles of the Nasal Mucosa Following Birch Pollen Provocation Differ Between Birch Pollen-Allergic and Non-Allergic Individuals.
Allergy
December 2024
Department of Dermatology, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, St. Poelten, Austria.
Article Synopsis
- Birch pollen (BP) exposure leads to significant changes in gene expression and cytokine levels in allergic individuals compared to non-allergic individuals, indicating distinct biological responses.
- RNA sequencing identified 160 genes activated in allergic participants, with specific pathways related to inflammation and immune response being enriched in their nasal secretions.
- The findings suggest that BP allergy triggers unique signaling mechanisms in predisposed individuals, providing insights for future research into allergy treatments.
Periprosthetic Joint Infection and Concomitant Sepsis: Unveiling Clinical Manifestations, Risk Factors, and Patient Outcomes.
J Arthroplasty
December 2024
Regensburg University Medical Center, Department of Trauma Surgery, Regensburg, Germany.
Article Synopsis
- This study focused on the connection between sepsis and periprosthetic joint infections (PJI) in the hip and knee, examining risk factors and outcomes associated with the condition.
- Among patients with PJI, 40.6% also had sepsis, with higher comorbidity indexes and specific infections like Staphylococcus aureus linked to increased sepsis risk, longer hospital stays, and higher mortality rates.
- The findings highlight the critical need for careful monitoring and prompt treatment for PJI patients to prevent severe complications and improve survival rates.
Evaluating the need for standardised disease manifestation categories in patients infected with the tick-borne encephalitis virus: A Delphi panel.
Ticks Tick Borne Dis
December 2024
Krankenhaus Nordwest, Frankfurt, Germany.
Categorization systems for tick-borne encephalitis virus (TBEV) infection lack consistency in classifying disease severity. To evaluate the need for a standard, consensus-based categorisation system for TBEV infection across subtypes, we gathered an expert panel of clinicians and scientists with diverse expertise in TBEV infection. Consensus was sought using the Delphi technique, which consisted of 2 web-based survey questionnaires and a final, virtual, consensus-building exercise.
View Article and Find Full Text PDFFood Allergy Genetics and Epigenetics: A Review of Genome-Wide Association Studies.
Allergy
December 2024
Division of Dermatology, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
Article Synopsis
- The review covers the genetic and epigenetic factors related to food allergies, including their inheritance and the advantages and limitations of study methods.
- Genome-wide association studies have identified 16 significant genetic variants linked to food allergies, often overlapping with other allergic conditions.
- The article emphasizes the importance of integrating genetic and epigenetic data for understanding disease mechanisms and suggests future implications for predicting food allergy risks and responses to treatment.
Photoreceptor-RPE loss ratio and fundus autofluorescence patterns as predictive factors for lesion progression in geographic atrophy.
Acta Ophthalmol
December 2024
Department of Ophthalmology, Landesklinikum Mistelbach-Gänserndorf, Mistelbach, Austria.
Article Synopsis
- This study investigates how the ratio of photoreceptor (PR) loss to retinal pigment epithelium (RPE) loss affects the progression of geographic atrophy (GA) in patients.
- The research included 87 treatment-naïve patients with GA and analyzed their multimodal images over a follow-up period of 6 to 24 months, discovering correlations between the visual patterns and rates of GA progression.
- Results indicated that higher PR-RPE loss ratios are associated with faster GA growth and specific abnormal fundus autofluorescence (FAF) patterns, providing insights for predicting disease progression based on imaging characteristics.
Self-administration of aspirin for acute chest pain-Does it prevent premature cardiovascular mortality?
Wien Klin Wochenschr
December 2024
Department of Internal Medicine 3, Karl Landsteiner University of Health Sciences, Dunant Platz 1, 3100, St. Poelten, Austria.
Article Synopsis
- Aspirin has long been recognized as a top-tier treatment for acute coronary syndrome, emphasizing its importance in emergency scenarios.
- Early use of aspirin is essential, especially when experiencing acute chest pain.
- While self-administering aspirin can be beneficial, there is a small risk of increased bleeding for those whose chest pain is not related to a heart attack.
Curriculum interventional cardiology-Austria.
Wien Klin Wochenschr
December 2024
Division of Cardiology, Medical University of Vienna, Vienna, Austria.
Article Synopsis
- The interventional cardiology curriculum is a structured training program focused on advanced interventional procedures.
- It outlines the necessary requirements for candidates, trainers, and training centers, including learning objectives and required skills.
- Based on the European Core Curriculum, the program is adapted to meet Austria's healthcare needs and aims to deliver high-quality patient care.
The potential impact of educational attainment on NAFLD risk. Author's reply.
Eur J Intern Med
December 2024
First Department of Medicine, University Clinic Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria; Institute of General Practice, Family Medicine and Preventive Medicine, Paracelsus Medical University of Salzburg, Salzburg, Austria; Department of Internal Medicine, Saint John of God Hospital, Teaching Hospital of the Paracelsus Medical Private University, Salzburg, Austria. Electronic address:
Real-world Evidence for Enfortumab Vedotin in Patients with Metastatic Urothelial Cancer: An Austrian Multicentre Study.
Clin Genitourin Cancer
November 2024
Department of Urology, Comprehensive Cancer Centre Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.
Article Synopsis
- Enfortumab vedotin (EV) is a new treatment option for patients with advanced urothelial carcinoma who haven't responded to other therapies.
- A study involving 128 patients in Austria showed an objective response rate of 31%, with median progression-free survival of 4.8 months and overall survival of 10.75 months.
- The treatment was found to be feasible and effective, with an acceptable safety profile, although lower efficacy was noted compared to earlier trials, likely due to the patient population being in later therapy lines.
Preoperative detection of extraprostatic tumor extension in patients with primary prostate cancer utilizing [Ga]Ga-PSMA-11 PET/MRI.
Insights Imaging
December 2024
Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Article Synopsis
- Radical prostatectomy (RP) is a standard treatment for localized prostate cancer, but accurately detecting extraprostatic extension (EPE) before surgery is difficult, which can lead to suboptimal treatments.
- This study explores using explainable machine learning to improve EPE detection by analyzing data from newly diagnosed prostate cancer patients who underwent PET/MRI imaging and subsequent surgery.
- The results showed machine learning models outperformed traditional imaging methods in predicting EPE, which could lead to better clinical decision-making and improved patient outcomes.
Treatment of stage IV colorectal cancer: A retrospective cohort study assessing whether failure of first‑line treatment indicates failure of second‑line treatment.
Mol Clin Oncol
January 2025
Karl Landsteiner University of Health Sciences, A-3500 Krems, Austria.
Article Synopsis
- Colorectal cancer (CRC) is a common and often late-diagnosed malignancy, where most patients receive 5-FU-based chemo-immunotherapy as the primary treatment option.
- A study of 49 patients with stage IV CRC showed that a positive response to first-line therapy significantly correlated with better outcomes in second-line treatment and overall survival, with those achieving complete response having a median survival of 80 months.
- The study also found that BRAF mutations indicated a poor prognosis, while other factors like sex and tumor location had no significant impact on overall survival in this patient group.
Article Synopsis
- The study investigates the stability and safety of faricimab, an anti-VEGF biologic, when compounded into two types of polypropylene syringes and stored for 28 days.
- No significant differences in binding affinity for VEGF and Ang-2 were observed between the syringe types, and the compound maintained its chemical and physical stability, sterility, and lack of bacterial endotoxins.
- These results support the safe off-label use of faricimab, potentially reducing costs while ensuring patient safety in clinical practice.
Clinical neurophysiology for tremor: Common questions in clinical practice.
Parkinsonism Relat Disord
January 2025
Clinica Alemana, Universidad del Desarrollo, Santiago, Chile; Instituto Nacional de Movimientos Anormales, Santiago, Chile. Electronic address:
Article Synopsis
- A detailed physical exam might not fully reveal the complexities of tremors; neurophysiology can help clarify these conditions.
- The study involved a panel of experts who investigated how neurophysiological techniques can enhance understanding of various movement disorders, especially different types of tremors.
- The findings emphasize the importance of neurophysiological assessments in accurately identifying and distinguishing between diverse tremor syndromes and other similar movement disorders.
Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy.
Res Pract Thromb Haemost
October 2024
Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.
Article Synopsis
- Sepsis-induced DIC is a serious condition with high morbidity and mortality, and factors like endothelial injury and extracellular vesicles (EV) are crucial in its development.
- The study examined the role of E-selectin, EV, tissue factor (TF), and tissue factor pathway inhibitor (TFPI) in identifying sepsis-induced coagulopathy by analyzing plasma samples from 87 sepsis patients.
- Findings indicated that while only TFPI and TF-PCA levels could effectively discriminate between patients with and without DIC, higher levels of TFPI specifically correlated with worsening DIC, suggesting that these markers could enhance diagnosis and treatment strategies in septic patients.
Editorial: Topical Collection "Ethical and Societal Implications of AgeTech".
Sci Eng Ethics
December 2024
Department of Gerontology, Simon Fraser University, Burnaby, Canada.
Article Synopsis
- AgeTech is an emerging sector that utilizes various technologies like mobile tech, robotics, and smart home systems to improve the lives of older adults.
- While it offers opportunities to empower seniors and improve their quality of life, significant ethical challenges must be addressed.
- The articles in this collection aim to explore these ethical issues, particularly around AI and robotics, and provide strategies for developing technology that supports the health and well-being of older individuals.
Areas of improvement for colorectal cancer screening: Results of a screening initiative for 10,000 health care employees in Austria.
Endosc Int Open
November 2024
GI Endoscopy Quality Matters working group (GIEQM), Karl Landsteiner University of Health Sciences, Krems, Austria.
Article Synopsis
- The study examined colorectal cancer (CRC) screening participation and quality in Austria, revealing significant gaps in meeting guideline quality metrics among screening colonoscopies.
- Out of 10,239 eligible employees, only 23% participated in stool-based screening, with a 24% positivity rate for tests; follow-up for colonoscopy was high at 84%.
- The adenoma detection rate (ADR) varied widely based on the type of endoscopist, with most European Society of Gastrointestinal Endoscopy quality indicators not being met, highlighting the need for improved quality assurance in CRC screening.
Gamified Digital Mental Health Interventions for Young People: Scoping Review of Ethical Aspects During Development and Implementation.
JMIR Serious Games
November 2024
Division Biomedical and Public Health Ethics, Karl Landsteiner University of Health Sciences, Krems, Austria.
Article Synopsis
- Young people face heightened mental health risks, worsened by COVID-19, and digital tools like apps and chatbots are emerging as helpful, stigma-free solutions, although they raise ethical concerns due to a lack of regulations.
- The study aims to explore the ethical implications of gamified digital mental health interventions for youth, highlighting the importance of integrating these tools into existing mental health frameworks.
- The review analyzed 38 research publications, focusing on key ethical considerations such as research ethics, privacy, empowerment, cultural sensitivity, and the socioeconomic impacts of these digital interventions.
Characteristics and outcomes of patients with acute coronary syndrome who present with atypical symptoms: a systematic review, pooled analysis and meta-analysis.
Coron Artery Dis
November 2024
Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.
Article Synopsis
- A systematic review of 43 studies involving over 1.6 million patients analyzed the frequency and outcomes of atypical presentations in acute coronary syndrome (ACS).
- The findings indicated that about 11.6% of patients presented atypically (without classic chest pain), with rates varying widely; up to 33.6% of patients had no chest pain at all.
- Factors increasing the likelihood of atypical presentation included non-ST-elevation myocardial infarction, greater Killip class, and a history of heart failure, with patients presenting atypically facing double the mortality risk compared to those with typical symptoms.
Evaluating flourishing: a comparative analysis of four measures using item pool visualization.
Front Psychol
November 2024
Department of Psychology and Psychodynamics, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria.
Article Synopsis
- The concept of flourishing, a key idea in positive psychology, represents a high level of wellbeing, but there's still debate among scientists on how to define and measure it, creating challenges for researchers.
- This study does a comparative analysis of four popular flourishing measurement tools: PERMA-Profiler, Mental Health Continuum-Short Form, Flourishing Scale, and Wellbeing Conceptual Framework, specifically in a German-speaking sample.
- Findings show that all four measures effectively assess flourishing, but they cater to different needs, with the first three providing a broader view and the Wellbeing Conceptual Framework focusing on more specific aspects of flourishing.
Declaration of Computational Neurosurgery.
Adv Exp Med Biol
November 2024
Department of Neurosurgery, Alfred Hospital, Melbourne, VIC, Australia.
Article Synopsis
- Computational neurosurgery combines artificial intelligence and computational modeling to enhance the diagnosis and treatment of neurosurgical conditions, aiming to advance clinical neurosciences.
- The field seeks to integrate ethical considerations to ensure that the use of AI is conducted responsibly and prioritizes patient care, ultimately aiming to prevent errors in treatment.
- This initiative serves as a guide for practitioners, ethicists, and scientists in the application of ethical standards within computational neurosurgery.
Breast Implants: Low Rate of Annual Check-Ups Results in Delayed Presentation of Ruptured Implants.
J Clin Med
October 2024
Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Article Synopsis
- Breast-implant-based reconstruction is common but can lead to serious complications like implant rupture, which may result in issues such as siliconoma and BIA-ALCL.
- A study of 1,128 breast procedures at the University Clinic of St. Poelten found that only 15.46% of patients followed annual check-up recommendations for their implants, leading to many visiting due to pain or aesthetic concerns instead.
- Most ruptures (73.8%) were diagnosed in patients who didn't have regular check-ups, emphasizing the importance of routine examinations to catch issues early and reduce the risk of severe complications.
Solitary Fibrous Tumor.
Cancers (Basel)
October 2024
Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Article Synopsis
- Solitary fibrous tumor (SFT) is a rare type of tumor that originates from mesenchymal tissues, which are the connective tissues in the body.
- It is classified as an orphan disease, meaning it affects a small number of people and may not have extensive research or treatments available.
- SFT can occur in various locations in the body, and while it is typically benign, they can sometimes become malignant, requiring careful monitoring and possible treatment.
A novel ionic liquid-based approach for DNA and RNA extraction simplifies sample preparation for bacterial diagnostics.
Anal Bioanal Chem
December 2024
Institute of Chemical, Environmental and Bioscience Engineering, Working Area Molecular Diagnostics 166/5/3, IFA Tulln, TU Wien, Tulln, Austria.
Article Synopsis
- DNA- and RNA-based diagnostics are crucial for detecting health-related bacteria, providing important information on their presence and treatment effectiveness.
- A new extraction protocol using an ionic liquid and magnetic beads enables quick and easy molecular diagnostics by efficiently capturing nucleic acids without needing extensive materials.
- This method demonstrates comparable or better performance than current commercial extraction kits, is cost-effective, requires minimal resources, and is suitable for rapid testing in various settings, promoting advancements in molecular diagnostics.
"A bit of a cough, tired, not very resilient - is that already Long-COVID?" perceptions and experiences of GPs with Long-COVID in year three of the pandemic. a qualitative interview study in Austria.
BMC Public Health
November 2024
Department of Primary Care Medicine, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15, Vienna, 1090, Austria.
Article Synopsis
- The study investigates the experiences and attitudes of general practitioners (GPs) in Austria regarding Long-COVID, highlighting how their understanding has evolved since the pandemic began.
- Thirty semi-structured interviews were conducted to gather qualitative data, revealing that while GPs have significant experience with Long-COVID, certain complex symptoms may not have been fully recognized or classified.
- The findings suggest that managing Long-COVID is challenging for GPs and patients alike, especially when treatments aren't effective, signaling that Long-COVID will remain a pressing issue in healthcare systems due to ongoing COVID-19 variants.