Human Serum Albumin Nanoparticles: Synthesis, Optimization and Immobilization with Antituberculosis Drugs.

The aim of this study was to create nanoparticles of human serum albumin immobilized with anti-TB drugs (rifampicin, isoniazid) using the desolvation method. Central Composite Design (CCD) was applied to study the effect of albumin, urea, L-cysteine, rifampicin and isoniazid concentration on particle size, polydispersity and loading degree of the drugs. The optimized nanoparticles were spherical in shape with an average particle size of 216.

Combined Computational and Experimental Studies of Anabasine Encapsulation by Beta-Cyclodextrin.

The encapsulation of the famous alkaloid, anabasine, with β-CD was studied to obtain a more stable and bioavailable inclusion complex. Various in silico and experimental studies of the obtained β-CD-anabasine complex are presented. Firstly, molecular docking studies were conducted against the α, β, and γ cyclodextrins to explore which subclass is the best for encapsulation.

Heterologous Dimension of the Other Sociality in the Cognitive Space of Uncertainty.

Contemporary society is presented as a model of other sociality demanding extraordinary methods of research in the cognitive space of uncertainty. This article aims at analyzing a heterologous paradigm of postnon-classical social philosophical discourse and how it applies to the socio-philosophical context of modernity by using cognitive and heuristic capabilities of social heterology which explain the uncertainty principle of social cognition in other sociality. The diversity of the other sociality is characterized by structural non-linearity, disequilibrium, rupture, decentralism, and lack of a unified systematic principle.

Combined In Silico and Experimental Investigations of Resveratrol Encapsulation by Beta-Cyclodextrin.

The results of the computational and the physicochemical studies of the encapsulation of resveratrol with β-cyclodextrin are presented here. At first, the molecular docking experiments predicted good binding. Several MD simulations and MM-PBSA experiments confirmed the reliable binding, showing optimal kinetics and energy.