Safety and tolerability of Sacubitril/Valsartan in heart failure patient with reduced ejection fraction.

Background: Angiotensin receptor blocker and a neprilysin inhibitor (ARNI) has emerged as an innovative therapy for patients of heart failure with reduced ejection fraction (HFrEF). The purpose of this study was to assess the safety and tolerability of Sacubitril/Valsartan in patient with HFrEF in Pakistani population.

Methods: This proof-of-concept, open label non-randomized clinical trial was conducted at a tertiary care cardiac center of Karachi, Pakistan.

Temporal trends in results of 9170 myocardial perfusion imaging studies (2004 to 2013).

Background: To assess the frequency of normal and abnormal myocardial perfusion imaging (MPI) in a consecutive cohort of patients from Pakistan over a period of 8.5 years.

Material And Methods: We assessed 9170 patients who had undergone stress-rest MPI between January 2004 and June 2013.

Higher event rate in patients with known CAD despite a normal myocardial perfusion scan.

Objective: The negative predictive value of a normal single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is very high. However, prognostic implication of a normal SPECT MPI in patients with known coronary artery disease (CAD) is not clear. Objective of this study was to evaluate the cardiac event rate in patients with known CAD who had a normal stress SPECT MPI.

Impact of glycosylated hemoglobin (HBA1C) on the extent of perfusion abnormalities and left ventricular dysfunction using gated myocardial perfusion imaging and clinical outcomes in diabetic patients.

Objectives: The aim of the study was to determine the impact of glycosylated hemoglobin (HBA1C) on the extent of perfusion abnormalities and left ventricular dysfunction (LVD) using gated myocardial perfusion imaging (GMPI) and clinical outcomes in diabetic patients.

Materials And Methods: A total of 1013 individuals (457 diabetic patients and 556 nondiabetic controls) were included in the study. Among the diabetic patients, 254 (56%) were male and 203 (44%) were female, with a mean age of 58 ± 9 years.

Predictive and prognostic values of transient ischemic dilatation of left ventricular cavity for coronary artery disease and impact of various managements on clinical outcome using technetium-99m sestamibi gated myocardial perfusion imaging.

Background: Transient ischemic dilatation (TID) of LV cavity during stress gated myocardial perfusion imaging (GMPI) is known as a predictor of severe CAD and signifies worse prognosis.

Objectives: To assess predictive and prognostic value of TID of LV cavity using GMPI and clinical outcome in patients treated conservatively or with revascularization.

Methods: 189 patients out of 2689 were recruited (M:F 127/62, mean age 56 ± 9 years) whose same-day stress GMPI revealed TID ratio (> 1.