Subungual verrucous carcinoma of the thumb treated by intra-arterial infusion with methotrexate.

Background: For preservation of integrity of appearance and function in a 66-year-old male with an extremely rare case of verrucous carcinoma developing from the subungium of his right thumb, intra-arterial infusion with methotrexate was used.

Objective: To evaluate the effectiveness of arterial infusion with methotrexate in this unusual nail bed cancer.

Methods: Right brachial arterial catheterization and infusion with methotrexate (50 mg) were used every 24 hours together with simultaneous intramuscular injection of 6 mg of leucovorin every 6 hours for 10 days.