The exploration of effect of terfenadine on Ca signaling in renal tubular cells.

Terfenadine, an antihistamine used for the treatment of allergic conditions, affected Ca-related physiological responses in various models. However, the effect of terfenadine on cytosolic free Ca levels ([Ca]) and its related physiology in renal tubular cells is unknown. This study examined whether terfenadine altered Ca signaling and caused cytotoxicity in Madin-Darby canine kidney (MDCK) renal tubular cells.

A gender-specific COMT haplotype contributes to risk modulation rather than disease severity of major depressive disorder in a Chinese population.

Background: COMT rs4680 Val158 allele is associated with high MB-COMT protein expression and elevated activity compared to the Met158 allele in post-mortem brains. A meta-analysis study suggested the link between COMT SNPs and MDD risk; in addition, MB membrane-bound (MB-COMT) specific genetic variation was reported that influences predisposition to depression amongst females.

Methods: Four tagSNPs, including rs4680, were genotyped.

Exploration of Niflumic Acid’s Action on Ca²⁺ Movement and Cell Viability in Human Osteosarcoma Cells.

Niflumic acid, a drug used for joint and muscular pain, affected Ca²⁺ signaling in different models. However, the effect of niflumic acid on Ca²⁺ homeostasis and Ca²⁺-related physiology in human osteosarcoma cells is unknown. This study examined the effect of niflumic acid on cytosolic free Ca²⁺ concentrations ([Ca²⁺]i) in MG63 human osteosarcoma cells.

Effects of timolol on Ca handling and viability in human prostate cancer cells.

Timolol is a medication used widely to treat glaucoma. Regarding Ca signaling, timolol was shown to modulate Ca-related physiology in various cell types, however, the effect of timolol on Ca homeostasis and cell viability has not been explored in human prostate cancer cells. The aim of this study was to explore the effect of timolol on intracellular Ca concentrations ([Ca]) and viability in PC3 human prostate cancer cells.

Development of an AVF Stenosis Assessment Tool for Hemodialysis Patients Using Robotic Ultrasound System.

With the aging population and lifestyle changes, the number of hemodialysis (HD) patients increases year by year. The arteriovenous fistula (AVF) is the gold standard vascular access used to access the blood for HD treatment. Since the status of stenosis affects HD efficiency, current clinical practices usually use a Doppler ultrasound imaging system to assess the parameters of the stenosis, such as the degree of stenosis (DOS).

Effect of Captopril on Ca²⁺ Homeostasis and Cell Viability in Human Hepatoma Cells.

Captopril, an angiotensin-converting enzyme (ACE) inhibitor, induced different Ca²⁺ signaling responses in various cell models. However, the effect of captopril on Ca²⁺ homeostasis and cell viability in hepatoma cells is unknown. This study examined whether captopril altered Ca²⁺ homeostasis and viability in HepG2 human hepatoma cells.

Antifibrotic role of PGC-1α-siRNA against TGF-β1-induced renal interstitial fibrosis.

Peroxisome proliferator-activated receptor coactivator-1 alpha (PGC-1α) is a transcriptional coactivator that regulates energy metabolism and mitochondrial biogenesis. Recently, mitochondrial dysfunction has been indicated as an established risk factor for the development of renal fibrosis. However, whether PGC-1α is involved in the pathogenesis of renal fibrosis is unknown.

Association of injury pattern and entrapment location inside damaged buildings in the 2016 Taiwan earthquake.

Background/purpose: To explore the association of patient injury patterns and entrapped locations inside damaged buildings in the 2016 Taiwan earthquake.

Methods: A retrospective analysis was conducted using the Tainan incident registry system. Residents inside nine conjunctive, 16-story (49.

The effect of magnolol on Ca homeostasis and its related physiology in human oral cancer cells.

Objective: Magnolol, a polyphenol compound from herbal medicines, was shown to alter physiology in various cell models. However, the effect of magnolol on Ca homeostasis and its related physiology in oral cancer cells is unclear. This study examined whether magnolol altered Ca signaling and cell viability in OC2 human oral cancer cells.

Amitriptyline modulated Ca signaling and induced Ca-independent cell viability in human osteosarcoma cells.

Amitriptyline is a widely used tricyclic antidepressant, which acts primarily as a serotonin-norepinephrine reuptake inhibitor. This study examined the effect of amitriptyline on Ca homeostasis and its related mechanism in MG63 human osteosarcoma cells. Amitriptyline evoked cytosolic-free Ca concentrations ([Ca]) rises concentration dependently.

Breast cancer screening with digital breast tomosynthesis - 4 year experience and comparison with national data.

Background: To determine if mammography combined with digital breast tomosynthesis (DBT), leads to superior performance in screening for breast cancer compared to digital mammography (DM) alone.

Methods: We retrospectively collected data from A) the results of population-based mammography-screening provided by the National Cancer Registry in Taiwan, and B) the results from all screening mammography performed with DBT from 2012 through 2015 at Kaohsiung Veterans General Hospital (VGHKS) since the institution of DBT at the end of 2011. This was compared data from 3 years with DM performed prior to DBT implementation.

Effect of Carvacrol on Ca²⁺ Movement and Viability in PC3 Human Prostate Cancer Cells.

Carvacrol, a monoterpenic phenol compound, has been shown to possess various biological effects in different models. However, the effect of carvacrol on intracellular Ca²⁺ and its related physiology in human prostate cancer is unknown. This study explored the effect of carvacrol on cytosolic free Ca²⁺ levels ([Ca²⁺]i) and viability in PC3 human prostate cancer cells.

Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells.

Epigenetic repression of the tumor suppressor gelsolin (GSN) is frequently observed in cancers. Chronic inflammation can promote tumor progression via aberrant DNA methylation. In this study, we investigated the role of tumor-associated macrophages (TAMs) in DNA methylation of the gene during gastric cancer progression.

Effect of tetramethylpyrazine (TMP) on Ca signal transduction and cell viability in a model of renal tubular cells.

Tetramethylpyrazine (TMP) is a compound purified from herb. Its effect on Ca concentrations ([Ca ] ) in renal cells is unclear. This study examined whether TMP altered Ca signaling in Madin-Darby canine kidney (MDCK) cells.

Effect of Methoxsalen on Ca²⁺ Homeostasis and Viability in Human Osteosarcoma Cells.

Methoxsalen is a natural compound found in many seed plants. The effect of methoxsalen on Ca²⁺- related physiology in human osteosarcoma is unclear. This study investigated the effect of methoxsalen on cytosolic free Ca²⁺ concentrations ([Ca²⁺]i) in MG63 human osteosarcoma cells.

Effect of Protriptyline on [Ca²⁺]i and Viability in MDCK Renal Tubular Cells.

Protriptyline has been used as an antidepressant. Clinically it has been prescribed in the auxiliary treatment of cancer patients. However, its effect on Ca²⁺ signaling and related physiology is unknown in renal cells.

Effects of puerarin on intracellular Ca and cell viability of MDCK renal tubular cells.

Puerarin is a natural compound and has been used as herb medication in a number of countries, especially in Asia. The effect of puerarin on Ca signaling is unknown in renal cells. This study examined whether puerarin affected Ca physiology in MDCK renal tubular cells.

Effect of protriptyline on [Ca] and viability in MG63 human osteosarcoma cells.

Tricyclic antidepressants (TCA) have been clinically prescribed in the auxiliary treatment of cancer patients. Although protriptyline, a type of TCA, was used primarily in the clinical treatment of mood disorders in cancer patients, the effect of protriptyline on physiology in human osteosarcoma is unknown. This study examined the effect of protriptyline on cytosolic free Caconcentrations ([Ca]) and viability in MG63 human osteosarcoma cells.

Elucidation of the therapeutic role of mitochondrial biogenesis transducers NRF-1 in the regulation of renal fibrosis.

Background: Mitochondrial dysfunction is a newly established risk factor for the development of renal fibrosis. Cell survival and injury repair is facilitated by mitochondrial biogenesis. Nuclear respiratory factor 1 (NRF-1) is a transcriptional regulation factor that plays a central role in the regulation of mitochondrial biogenesis.

Sleep apnea is associated with an increased risk of mood disorders: a population-based cohort study.

Purpose: The symptoms of sleep apnea, such as sleep fragmentation and oxygen desaturation, might be risk factors for subsequent mood disorder (MD), but associations between sleep apnea and MD remain unclear. This nationwide population-based study thus aimed to identify the risk of MD in patients with vs. without sleep apnea.

Treatment with cytokine thymic stromal lymphopoietin short hairpin RNA substantially reduces TGF-β1-induced interstitial cellular fibrosis.

Thymic stromal lymphopoietin (TSLP) has previously been linked to allergic inflammatory diseases, and tissue fibrosis and organ dysfunction may also arise from such inflammation. It remains unclear, however, whether TSLP plays any role in the occurrence of renal fibrosis, so this study investigated that possibility. An in vitro fibrosis model was established by treating normal rat kidney fibroblast (NRK-49F) cells with transforming growth factor-β1 (TGF-β1), after which the levels of various fibrogenic markers (e.

Improving risk assessment and familial aggregation of age at onset in schizophrenia using minor physical anomalies and craniofacial measures.

Age at onset is the most important feature of schizophrenia that could indicate its origin. Minor physical anomalies (MPAs) characterize potential marker indices of disturbances in early neurodevelopment. However, the association between MPAs and age at onset of schizophrenia is still unclear.

Effect of 2,5-dimethylphenol on Ca(2+) movement and viability in PC3 human prostate cancer cells.

The phenolic compound 2,5-dimethylphenol is a natural product. 2,5-Dimethylphenol has been shown to affect rat hepatic and pulmonary microsomal metabolism. However, the effect of 2,5-dimethylphenol on Ca(2+ )signaling and cyotoxicity has never been explored in any culture cells.

Novel Wearable Device for Blood Leakage Detection during Hemodialysis Using an Array Sensing Patch.

Hemodialysis (HD) is a clinical treatment that requires the puncturing of the body surface. However, needle dislodgement can cause a high risk of blood leakage and can be fatal to patients. Previous studies proposed several devices for blood leakage detection using optical or electrical techniques.

Ca Signaling and Cell Death Induced by Protriptyline in HepG2 Human Hepatoma Cells.

The effect of protriptyline on Ca physiology in human hepatoma is unclear. This study explored the effect of protriptyline on [Ca ] and cytotoxicity in HepG2 human hepatoma cells. Protriptyline (50-150 μM) evoked [Ca ] rises.