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Increased activation of the Wnt/β-catenin pathway in spontaneous hepatocellular carcinoma observed in farnesoid X receptor knockout mice.
J Pharmacol Exp Ther
July 2011
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas Life Sciences Innovation Center 4087, Mail Stop 1018, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.
Farnesoid X receptor (FXR), the primary bile acid-sensing nuclear receptor, also is known for its anticancer properties. It is known that FXR deficiency in mice results in spontaneous hepatocellular carcinoma (HCC), but the mechanisms are not completely understood. We report that sustained activation of the Wnt/β-catenin pathway is associated with spontaneous HCC in FXR-knockout (KO) mice.
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