10 results match your criteria: "Kansas City (Dr Reeder); and Loyola University Medical Center[Affiliation]"
Positive Airway Pressure, Mortality, and Cardiovascular Risk in Older Adults With Sleep Apnea.
JAMA Netw Open
September 2024
Department of Health Management and Informatics, School of Medicine, University of Missouri-Columbia.
Importance: Positive airway pressure (PAP) is the first-line treatment for obstructive sleep apnea (OSA), but evidence on its beneficial effect on major adverse cardiovascular events (MACE) and mortality prevention is limited.
Objective: To determine whether PAP initiation and utilization are associated with lower mortality and incidence of MACE among older adults with OSA living in the central US.
Design, Setting, And Participants: This retrospective clinical cohort study included Medicare beneficiaries with 2 or more distinct OSA claims identified from multistate, statewide, multiyear (2011-2020) Medicare fee-for-service claims data.
Characterizing Long COVID in Children and Adolescents.
JAMA
August 2024
Division of Child and Adolescent Health, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York.
Article Synopsis
- Research highlights a critical gap in understanding long COVID (PASC) in children and emphasizes the need for studies that define its characteristics in this age group.
- The objective is to identify common prolonged symptoms in children aged 6 to 17 post-SARS-CoV-2 infection, examining differences between school-age kids and adolescents, as well as potential symptom clusters for future research.
- A multicenter study involved nearly 5,000 participants, revealing that certain symptoms were significantly more prevalent in those with a history of COVID-19 compared to those without.
Characteristics of Pediatric In-Hospital Cardiac Arrests and Resuscitation Duration.
JAMA Netw Open
July 2024
Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia.
Article Synopsis
- The study investigates the relationship between CPR duration and survival outcomes in hospitalized children who experience cardiac arrest and do not achieve return of circulation (ROC).
- It involved two analyses: a patient-level examination of CPR duration factors and a hospital-level analysis looking at the association between hospital median CPR duration and survival rates among patients without ROC.
- Results indicated that among 13,899 CPR events, 3,859 patients did not achieve ROC, with a longer median CPR duration observed in those who did not survive, highlighting the significance of CPR duration in cardiac arrest survival.
Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design.
PLoS One
May 2024
Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, United States of America.
Importance: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults.
Observations: We describe the protocol for the Pediatric Observational Cohort Study of the NIH's REsearching COVID to Enhance Recovery (RECOVER) Initiative.
Comparison of the PCPLC Database to NSQIP-P: A Patient Matched Comparison of Surgical Complications Following Repair of Anorectal Malformation.
J Pediatr Surg
May 2024
Department of General Surgery, Seattle Children's Hospital, University of Washington, 4800 Sandpoint Way NE, Seattle, WA 98105, USA.
Article Synopsis
- Anorectal malformations (ARM) are rare and complex, making research and best practice recommendations difficult, prompting the formation of the Pediatric Colorectal and Pelvic Learning Consortium (PCPLC) in 2016 and the creation of a national data registry.
- This study aimed to evaluate the accuracy of the PCPLC database by comparing 30-day surgical outcomes for ARM patients under 12 months old with data from the NSQIP-P database.
- The results showed a high 91% concordance rate between the two databases in recorded complications, improving to 93% when excluding complications not tracked by PCPLC, suggesting a strong validation of PCPLC data for ARM patients.
Importance: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals.
Objective: To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections.
Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design.
medRxiv
May 2023
Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, USA.
Article Synopsis
- - The RECOVER-Pediatrics study aims to investigate the prevalence and long-term effects of Long COVID (PASC) in children and young adults, addressing the need for more research in this area.
- - The study recruits caregiver-child pairs and young adults across 100+ sites in the U.S., focusing on a diverse group of participants with and without prior SARS-CoV-2 infections, and will collect data over several years through various tiers of assessments.
- - The ultimate goal of the study is to understand the clinical trajectory, mechanisms, and sociodemographic factors related to pediatric PASC, thereby contributing to potential treatments and public health responses.
Anticoagulation Monitoring in the Intensive Care Unit.
Crit Care Nurs Q
March 2022
Wesley Medical Center, Wichita, Kansas (Drs Gilbert, Reynolds, and Tabaka); University of Kansas Health System, Kansas City (Dr Reeder); and Loyola University Medical Center, Maywood, Illinois (Dr Rech).
Patients with critical illness often display variable hypo- and hypercoagulable sequalae requiring intense monitoring and anticoagulation pharmacotherapy to prevent or treat inappropriate clot formation. It is imperative to understand the various stages of the clotting cascade and where each pharmacotherapy agent exerts its therapeutic effect. Common coagulation tests are utilized to monitor the areas of the clotting cascade and the effects that anticoagulant pharmacotherapy exhibits.
View Article and Find Full Text PDFPerioperative and long-term functional outcomes of neonatal versus delayed primary endorectal pull-through for children with Hirschsprung disease: A pediatric colorectal and pelvic learning consortium study.
J Pediatr Surg
August 2021
Division of Pediatric Surgery, Department of Surgery, University of Utah School of Medicine, Primary Children's Hospital, 100N. Mario Cappecchi Dr., Suite 3800, Salt Lake City, UT 84113, United States.
Background/purpose: the timing of endorectal pull-through for Hirschsprung disease (HD) is controversial. Neonatal primary endorectal pull-through theoretically prevents preoperative enterocolitis. Delayed primary endorectal pull-through offers the surgeon the benefit of more robust perineal anatomy and allows primary caregivers the time to emotionally process the diagnosis and to gain experience with rectal irrigations.
View Article and Find Full Text PDFComparative Effectiveness of Aspirin Dosing in Cardiovascular Disease.
N Engl J Med
May 2021
From Duke Clinical Research Institute, Duke University, Durham (W.S.J., H.M., L.M.W., M.J.P., M.T.R., H.R.R., L.H.C., A.G.S., L.G.B., B.G.H., D.F.H., L.G.Q., G.M.-G., A.F.H.), University of North Carolina at Chapel Hill, Chapel Hill (D.A.D.), and Wake Forest University School of Medicine, Winston-Salem (L.Z.) - all in North Carolina; Vanderbilt University Medical Center, Nashville (S.K., D.M., D.L.C., R.L.R.); Ochsner Health (M.B.E., R.N.R.) and Louisiana Public Health Institute (T.W.C., E.N.) - both in New Orleans; University of Kansas Medical Center, Kansas City (K.G.); University of Florida, Gainesville (R.D.A., C.J.P., E.M.H., B.R.M., E.A.S.); University of Pittsburgh Medical Center, Pittsburgh (S.K.J., K.M.M.), Penn State College of Medicine, Hershey (J.L.K.), and Temple University, Philadelphia (A.P.) - all in Pennsylvania; University of Iowa, Iowa City (S.G., D.R.); Medical College of Wisconsin, Milwaukee (J.W.), and Marshfield Clinic Research Institute, Marshfield (J.J.V.) - both in Wisconsin; Albert Einstein College of Medicine, Bronx (Y.H.G.), and Weill Cornell Medicine and New York-Presbyterian Hospital, New York (R.K.) - both in New York; Mayo Clinic, Rochester (V.L.R.), Essentia Health Heart and Vascular Center, Duluth (C.P.B.), and Allina Health and Minneapolis Heart Institute, Minneapolis (S.M.B.) - all in Minnesota; University of Utah School of Medicine (R.H.) and Intermountain Medical Center Heart Institute (K.U.K.) - both in Salt Lake City; University of Michigan, Ann Arbor (P.F.); Johns Hopkins University School of Medicine, Baltimore (D.E.F.); HealthCore, Wilmington, DE (K.H.); University of Chicago Medicine (T.S.P.) and Northwestern University Feinberg School of Medicine (D.J.F., F.S.A., A.M.K.) - both in Chicago; University of Nebraska Medical Center, Omaha (J.C.M., J.R.C.); University of California, Los Angeles, Los Angeles (D.S.B., G.C.F.), University of California, San Francisco, San Francisco (M.F.M., G.M.M.), and Stanford University School of Medicine, Stanford (R.A.H.) - all in California; University of Missouri School of Medicine, Columbia (L.R.W.); University of Colorado School of Medicine, Anschutz Medical Campus, Aurora (F.A.M.); Brigham and Women's Hospital, Harvard Medical School, Boston (E.M.A.); Chicago (D.R.D.); St. Joseph, MO (K.E.); Brighton, MI (J.G.M.); Columbia, TN (L.S.B.); Alachua, FL (D.N.Z.); Columbia, MD (T.E.M.); North Hills, CA (J.D.A.); and Metairie, LA (K.C.G.).
Background: The appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke and to minimize major bleeding in patients with established atherosclerotic cardiovascular disease is a subject of controversy.
Methods: Using an open-label, pragmatic design, we randomly assigned patients with established atherosclerotic cardiovascular disease to a strategy of 81 mg or 325 mg of aspirin per day. The primary effectiveness outcome was a composite of death from any cause, hospitalization for myocardial infarction, or hospitalization for stroke, assessed in a time-to-event analysis.