Microbial Diversity and Resistome in Milk of Cows with Subclinical Mastitis in a Coastal District of Odisha, India.

Mastitis is a globally prevalent bacterial disease of lactating cows. Prevention and control of this multi-etiological complex disease relies upon administration of antibiotics. This has led to the emergence of newer multi-drug resistant strains.

Advancements in framework materials for enhanced energy harvesting.

Energy harvesting, the process of capturing ambient energy from various sources and converting it into usable electrical power, has attracted a lot of attention due to its potential to provide long-term and self-sufficient energy solutions. This comprehensive review thoroughly explores the use of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) for energy harvesting by piezoelectric and triboelectric nanogenerators (PENGs and TENGs). It begins by classifying and outlining the structural diversity of MOFs and COFs, which is key to understanding their importance in energy applications.

From Passive Listeners to Active Learners: Changing Student Preferences in Small Group Learning for the MBBS Curriculum.

The shift toward student-centered learning in medical education has become increasingly apparent in recent years, particularly in small group learning (SGL) within the MBBS curriculum. Traditionally, SGL has been teacher-led, but data from three polls conducted across three MBBS batches (2019, 2022, and 2023) highlight a notable shift in student preferences toward more active learning methods. While the 2019 batch overwhelmingly favored teacher-led explanations, the 2022 and 2023 batches showed a growing preference for self-directed learning, with "Self-reading and Doubt Clearing" becoming the most popular mode by 2023.

Predictive relevance of optical coherence tomography indices in conjunction with visual acuity and surgical outcomes of idiopathic macular hole.

Idiopathic macular hole (IMH) is a condition that arises from a combination of interactions among several forces on the fovea, remarkably from vitreous traction in the anteroposterior and tangential directions. Recent studies have highlighted the significance of microincision vitrectomy surgery, and IMH surgery was performed with minimal invasiveness, and visual improvement was an expected outcome. This study aimed to observe the pre-operative optical coherence tomography (OCT) indices correlated with visual acuity in the closure of IMH after surgery.

Economic Evaluation of Total Knee Replacement Compared with Non-Surgical Management for Knee Osteoarthritis in India.

Objective: This study is an economic evaluation of total knee replacement (TKR) in comparison with non-surgical management in India.

Methods: Cost-utility analysis and budget impact analysis (BIA) were conducted on individuals aged ≥ 50 years with osteoarthritis of the knee (OA knee) Kellgren-Lawrence grades 2 and 3 using a provider's perspective. Three scenarios were considered, varying the age at which TKR is administered while assuming a 20-year lifespan for the implant.

Mindfulness as a Path to Freedom from Internet Addiction in Adolescents: A Narrative Review.

In recent years, Internet Addiction Disorder (IAD) has become a major mental health concern among adolescents, with detrimental effects on social relationships, academic performance, and emotional well-being. The focus of mindfulness-based interventions (MBIs) on improving self-awareness, emotional regulation, and cognitive flexibility has drawn interest in MBIs as possible therapeutic approaches for treating IAD. The purpose of this narrative review is to investigate how mindfulness interventions affect teenagers who are experiencing IAD.

Metagenomic study of lake microbial mats reveals protease-inhibiting antiviral peptides from a core microbiome member.

In contrast to the large body of work on bioactive natural products from individually cultivated bacteria, the chemistry of environmental microbial communities remains largely elusive. Here, we present a comprehensive bioinformatic and functional study on a complex and interaction-rich ecosystem, algal-bacterial (microbial) mats of Lake Chilika in India, Asia's largest brackish water body. We report the bacterial compositional dynamics over the mat life cycle, >1,300 reconstructed environmental genomes harboring >2,200 biosynthetic gene clusters (BGCs), the successful cultivation of a widespread core microbiome member belonging to the genus , heterologous reconstitution of two silent biosynthetic pathways, and new compounds with potent protease inhibitory and antiviral activities.

Identification and validation of miR-21 key genes in cervical cancer through an integrated bioinformatics approach.

Cervical cancer is one of the most prevalent female reproductive cancers. miR-21 is a multi-target oncomiR that has shown its potential in regulating several cancers including colon, pancreatic, breast, prostate, ovarian, and cervical cancer. However, the signaling network of miR-21 remains underexplored, and only a limited number of miR-21 gene targets in cervical cancer have been reported.

Diagnostic performance of artificial intelligence in detecting oral potentially malignant disorders and oral cancer using medical diagnostic imaging: a systematic review and meta-analysis.

Objective: Oral cancer is a widespread global health problem characterised by high mortality rates, wherein early detection is critical for better survival outcomes and quality of life. While visual examination is the primary method for detecting oral cancer, it may not be practical in remote areas. AI algorithms have shown some promise in detecting cancer from medical images, but their effectiveness in oral cancer detection remains Naïve.

Metamaterial-based Artificial magnetic conductor for efficient breast cancer diagnosis using a low-cost antenna array.

Breast cancer is the most common malignancy in women globally, stemming from gene mutations that prompt irregular cellular growth and subsequent tumor development. Early-stage detection of cancer cells results in a remarkable 99% survival rate. This research presents a microwave imaging technique for the non-invasive identification of tumors in the initial stages within the women's breast.

Innovations in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and nanocomposites for sustainable food packaging via biochemical biorefinery platforms: A comprehensive review.

The substantial build-up of non-biodegradable plastic waste from packaging sector not only poses severe environmental threats but also hastens the depletion of natural petroleum-based resources. Presently, poly (3-hydroxybutyrate-co-3-hydroxy valerate) (PHBV), received enormous attention as ideal alternatives for such traditional petroleum-derived plastics based on their biocompatibility and superior mechanical properties. However, high cost of such copolymer, due to expensive nature of feedstock, inefficient microbial processes and unfavorable downstream processing strategies restricts its large-scale commercial feasibility in the packaging sector.

Revitalizing the Smile: A Case Report on the Modified Apexification Procedure for Discolored Non-Vital Immature Teeth With Periapical Lesions.

Apexification is the process of forming mineralized tissue at the apical portion of a tooth with an incompletely formed root. Although various materials and techniques for the endodontic treatment of such teeth have been employed for some time, selecting the appropriate material remains challenging due to limited literature. This report presents a case that evaluates the efficacy of a modified apexification procedure using mineral trioxide aggregate (MTA), followed by a walking-bleach technique to address discoloration resulting from trauma to anterior teeth.

Degradation of Decabromodiphenyl Ether Dispersed in Poly (Acrylo-Butadiene-Styrene) Using a Rotatory Laboratory Pilot Under UV-Visible Irradiation.

The growing volume of plastics derived from electronic waste (e-waste) underscores the imperative for environmentally sustainable strategies for the management of this waste. In light of the paramount importance of this issue, a pilot demonstrator for the decontamination of polymers containing Brominated Flame Retardants (BFRs) has been developed. The objective is to investigate the potential for decontaminating BFR-containing polymers from e-waste via UV-visible irradiation using a rotatory laboratory pilot operating under primary vacuum conditions.

Determining the effect of long non-coding RNA maternally expressed gene 3 (lncRNA MEG3) on the transcriptome profile in cervical cancer cell lines.

This study investigates the role of the long non-coding RNA Maternally Expressed Gene3 (lncRNA MEG3) gene in cervical cancer, as evidenced by its downregulation in cancerous cell lines. The study demonstrates the effects of the overexpression of lncRNA MEG3 in cervical cancer cell lines, particularly in C33A and CaSki. Through comprehensive analyses, including Next-Generation Sequencing (NGS), alterations in global mRNA expression were analyzed.

Hormones in malaria infection: influence on disease severity, host physiology, and therapeutic opportunities.

Human malaria, caused by Plasmodium parasites, is a fatal disease that disrupts the host's physiological balance and affects the neuroendocrine system. This review explores how malaria influences and is influenced by hormones. Malaria activates the Hypothalamus-Pituitary-Adrenal axis, leading to increased cortisol, aldosterone, and epinephrine.

CAD-PsorNet: deep transfer learning for computer-assisted diagnosis of skin psoriasis.

Psoriasis, being a chronic, inflammatory, lifelong skin disorder, has become a major threat to the human population. The precise and effective diagnosis of psoriasis continues to be difficult for clinicians due to its varied nature. In northern India, the prevalence of psoriasis among adult population ranges from 0.

PIM1 kinase and its diverse substrate in solid tumors.

The PIM kinase family, consisting of PIM1, PIM2, and PIM3, is a group of serine/threonine protein kinases crucial for cellular growth, immunoregulation, and oncogenesis. PIM1 kinase is often overexpressed in solid and hematopoietic malignancies, promoting cell survival, proliferation, migration, and senescence by activating key genes. In vitro and in vivo studies have established the oncogenic potential of PIM1 kinases.

Involvement of E3 Ubiquitin Ligases in Viral Infections of the Human Host.

Viral infections are one of the principal causes of global primary health crises, with increased rate of infection and mortality demonstrated by the newer progeny of viruses. Viral invasion of the host involves utilization of various cellular machinery. Ubiquitination is one of a few central regulatory systems used by viruses for establishment of the infections in the host.

Understanding the habitat vulnerability of Slums to COVID 19: Case of two megacities of India.

Background: Urban slums are hotspots of infectious diseases like COVID-19 as was seen in the waves of 2020 and 2021. One of the primary reasons why slums are disproportionately affected is their location in inaccessible and uninhabitable zones, crowded and poorly ventilated living spaces, unsanitary conditions and common facilities (water taps, common toilets, etc.).

Recent Updates on Diverse Nanoparticles and Nanostructures in Therapeutic and Diagnostic Applications with Special Focus on Smart Protein Nanoparticles: A Review.

Nanomedicine enables advanced therapeutics, diagnostics, and predictive analysis, enhancing treatment outcomes and patient care. The choices and development of high-quality organic nanoparticles with relatively lower toxicity are important for achieving advanced medical goals. Among organic molecules, proteins have been prospected as smart candidates to revolutionize nanomedicine due to their inherent fascinating features.

Targeted Therapy in Breast Cancer: Advantages and Advancements of Antibody-Drug Conjugates, a Type of Chemo-Biologic Hybrid Drugs.

Cancer is a significant health challenge globally, with millions of people affected every year, resulting in high morbidity and mortality. Although other treatment options are available with limitations, chemotherapy, either standalone or combined with other therapeutic procedures, is the most commonly used practice of treating cancer. In chemotherapy, cancer cells/malignant tumors are targeted; however, due to less target specificity, along with malignant cells, normal cells are also affected, which leads to various off-target effects (side effects) that impact the patient quality of life.

Mental health issues and the association of mental health literacy among adolescents in urban Ethiopia.

Background: Epidemiological evidence about the prevalence of adolescent mental health issues and their association with mental health literacy is crucial for sustained mental health promotion strategies. Adolescence is a critical life stage for mental health promotion. However, evidence is not available among Ethiopian school adolescents.

Changes in Smoking Patterns in Turkey Before and After the Ban on Loose Cigarettes: An Ecological Perspective From Global Tobacco Surveillance Data.

Introduction: Loose or individual cigarettes sold without packaging pose a unique challenge for tobacco control, which is the leading cause of premature and preventable mortality worldwide. This study aims to assess the changes in smoking patterns following the ban on loose cigarettes in 2008 in Turkey.

Method: Gender-stratified trend analysis of smoking patterns before and after the ban on loose cigarettes was done using the Global Tobacco Surveillance data (adults: Global Adult Tobacco Survey (GATS) 2008, 2012, and 2016; youth: Global Youth Tobacco Survey (GYTS) 2003, 2005, 2009, 2012, and 2017) from Turkey.