A pilot study on the pharmacokinetics of a single intramuscular injection of cefquinome in Arabian camel calves.

This study was conducted to evaluate the pharmacokinetics of cefquinome in camel calves after a single intramuscular injection in a dose of 2 mg/kg body weight (kg b. w.).

Investigation on heat transfer enhancement of conventional and staggered fin solar air heater coated with CNT-black paint-an experimental approach.

The present study aims at a detailed experimental study of a passive-type solar air heater (SAH) on the effect of coating the absorber plate with higher thermal conductive black paint under forced circulation method and studied under the climatic conditions of Chennai. Furthermore, to enhance the thermal performance index of conventional SAH, additional enhancement such as coating and staggered fins are fixed to the absorber plate of duct which simultaneously increases the turbulent intensity, kinetic energy to enhance the temperature of outlet air. Comparisons are made with a solar air heater without coating and staggered fin in order to assess the thermal performance.

Cefotaxime pharmacokinetics in Arabian camel (Camelus dromedarius) calves after single intravenous injection.

Cefotaxime is a third-generation broad-spectrum cephalosporin acting on a wide range of Gram-positive and Gram-negative bacteria. In this work, the pharmacokinetics of cefotaxime were determined in dromedary camel calves by single intravenous injection of 10 mg/kg b.w.

Assessment of Anticholinergic Use After Fading of BTX-A Effects in Refractory Idiopathic Overactive Bladder: A Prospective Blinded Randomized Trial.

Purpose: To evaluate the efficacy and safety of re-treatment with anticholinergics on refractory idiopathic overactive bladder (OAB) previously treated with intravesical botulinum neurotoxin type A (BTX-A) injections.

Methods: One hundred patients were initially managed by intravesical injections of 100 IU of BTX-A. After the effects of BTX-A faded, patients were randomized into 2 groups: group A patients received solifenacin (10 mg) for 12 weeks (study group), while group B patients received placebo treatment for 12 weeks (control group), then subsequently received solifenacin (10 mg) for another 6 weeks.

Development of an adaptive radial basis function neural network estimator-based continuous sliding mode control for uncertain nonlinear systems.

In this paper an adaptive neural network (NN)-based nonlinear controller is proposed for trajectory tracking of uncertain nonlinear systems. The adopted control algorithm combines a continuous second-order sliding mode control (CSOSMC), the radial basis function neural network (RBFNN) and the adaptive control methodology. First, a second-order sliding mode control scheme (SOSMC), which is published recently in literature for linear uncertain systems, is extended for nonlinear uncertain systems.

Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-γ agonists and anti-inflammatory COX-2 selective inhibitors.

Nowadays, diabetes and its associated inflammatory complications are important public health problems worldwide. Market limitations of drugs with dual actions as anti-inflammatory (AI) and anti-diabetic have been led to a temptation for focusing on the discovery and development of new compounds with potential AI and anti-diabetic activities. Herein, we synthesized two new series containing pyrazole ring with vicinal diaryl rings as selective COX-2 moiety and thiazolidindione (series 12a-f) or thiazolidinone (series 13a-f) as anti-diabetic moiety and the two moieties were linked together with methylene or methylenehydrazone functionality.

In silico molecular docking analysis of the human Argonaute 2 PAZ domain reveals insights into RNA interference.

RNA interference (RNAi) is a critical cellular pathway activated by double stranded RNA and regulates the gene expression of target mRNA. During RNAi, the 3' end of siRNA binds with the PAZ domain, followed by release and rebinding in a cyclic manner, which deemed essential for proper gene silencing. Recently, we provided the forces underlying the recognition of small interfering RNA by PAZ in a computational study based on the structure of Drosophila Argonaute 2 (Ago2) PAZ domain.

Current and future asthma therapies.

Corticosteroids (CST) are the gold standard for asthma management and for several decades have been considered the cornerstone for asthma control. With the recent advent of genomic and structural analysis technologies, the molecular basis of the side effects, toxicity and resistance mechanisms of drug treatment are better understood. With respect to CST, there is consistent evidence that while CST therapy improves asthma symptoms, it does not alter the natural course of asthma or offer clear long-lasting improvement of respiratory performance.

Identification and mechanism of Echinochloa crus-galli resistance to fenoxaprop-p-ethyl with respect to physiological and anatomical differences.

Identification and mechanism of Echinochloa crus-galli (L.) resistance to fenoxaprop-p-ethyl via physiological and anatomical differences between susceptible and resistant were investigated. The physiological and anatomical differences that were take into account were growth reduction, chlorophyll content reduction, lamina thickness, and xylem vessel diameter in both susceptible and resistant biotypes of E.

Analysis of the molecular interactions and complexation of chloroquine with bovine serum albumin.

Background: Pharmacokinetic parameters, drug bioavailability, and biological activities depend on the mechanisms of interaction with serum albumin. In this study, the binding properties as well as mechanisms of interaction of chloroquine with bovine serum albumin (BSA) were investigated.

Methods: The binding of chloroquine with BSA was carried out using a microcalorimetric approach.