QuEChERS methodology and Gas Chromatography-mass spectrometry for detection of 345 pesticide residues in Egyptian poultry feed: a comprehensive study.

Animal feed significantly influences the content and quality of animal products consumed by humans and plays a crucial role in the food chain. To simultaneously analyze 345 pesticide residues in poultry feed, a modified Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method was developed, utilizing gas chromatography-tandem mass spectrometry (GC-MS/MS). Validation studies were conducted with spiked pesticide standards, and commercial poultry feed samples were analyzed.

Effect of using heart of date palm as a new source of protein, carbohydrates, and bioactive compounds on the characterization of low-fat camel milk ice cream.

The heart of the date palm is a nutrient-rich vegetable found at the center of palm trees, abundant in protein and dietary fiber, primarily made up of carbohydrates. Preliminary studies indicate that the heart of the date palm possesses healing properties, exhibiting potent cytotoxic effects against HepG2 cells, suggesting its potential in cancer treatment. A low-fat ice cream was created using camel milk, enriched with varying amounts of heart of date palm-4 %, 8 %, and 12 % of the mix-as a source of bioactive compounds, protein, and carbohydrates.

Radio-clinical assessment of crista fenestra during pediatric cochlear implantation.

Objectives: This study aimed to assess the ability of preoperative computed tomography (CT) to predict the crista fenestra (CF) type during cochlear implantation and correlate these types with intraoperative findings. This may allow for precise preoperative planning with better surgical outcomes.

Study Design: A prospective observational study.

Near-complete telomere-to-telomere de novo genome assembly in Egyptian clover (Trifolium alexandrinum).

Egyptian clover (Trifolium alexandrinum L.), also known as berseem clover, is an important forage crop to Semi-arid conditions that was domesticated in ancient Egypt since 6,000 years BC and introduced and well adapted to numerous countries including India, Pakistan, Turkey, and Mediterranean region. Despite its agricultural importance, genomic research on Egyptian clover has been limited to developing efficient modern breeding programs.

Comparison of the Analgesic Efficacy of Erector Spinae Plane Block, Paravertebral Block and Quadratus Lumborum Block for Pelvi-ureteric Surgeries: A Randomized Double-Blind, Noninferiority Trial.

Background: Effective postoperative analgesia enhances the patient's comfort and facilitates early mobilization and recovery.

Objective: This study compared the analgesic efficacy of the erector spinae plane block (ESPB), thoracic paravertebral block (TPVB), and quadratus lumborum block (QLB) for pelvi-ureteric surgeries. The primary outcome measure in the study was the total morphine consumption during the first 48 hours following the operation.

Shear Strengthening of RC Beams Using Prestressed Near-Surface Mounted Bars Reducing the Probability of Construction Failure Risk.

In this study, shear-critical reinforced concrete (RC) beams were strengthened by combining the prestressing and near-surface mounted (NSM) rods approaches. The potential danger of failure in such RC beams is a substantial concern as it is considered a potential threat. This study addresses its careful mitigation through experimental identification and numerical analysis to enhance the safety and sustainability of buildings by reducing the probability of failure risk for these RC beams.

Effect of thymidine kinase-deficiency (∆ORF38) on neuropathogenicity of equine herpesvirus-1 in the mouse model and expression of neighboring genes.

Previous studies showed that deletion of the viral thymidine kinase (TK) gene in several alphaherpesviruses including EHV-1 reduced their virulence. Previously, we found that deletion of ORF37, which is located head-to-head with TK, decreased EHV-1 virulence in mice but did not affect the expression of TK mRNA. Therefore, deletion of ORF38 might also affect virulence by partially deleting the ORF37 promoter.

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as mortality predictors in acute Aluminum phosphide (grain pills) poisoning: clinical insights and risk assessment.

Background: Aluminum phosphides (AlP) is a solid fumigant pesticide known for its high toxicity and mortality. Diagnosis of AlP is based on the history and clinical examination. The literature on the early prediction of adverse outcomes following AlP exposure is limited.

Design, synthesis, and evaluation of novel benzofuran and pyrazole-based derivatives as dual AChE/BuChE inhibitors with antioxidant properties for Alzheimer's disease management.

As a complicated neurodegenerative disorder with several clinical hallmarks, Alzheimer's disease (AD) requires multi-target treatment medicines to address multiple elements of disease progression. In this study, we reported two novel series of compounds: benzofuran-based donepezil analogs (9a-i) and their pyrazole-based counterparts (11a-i) as potential dual inhibitors of AChE and BuChE with additional antioxidant properties, aiming to address multiple pathological aspects of AD simultaneously. The design strategy employed bioisosteric replacement, substituting donepezil's indanone motif with a benzofuran ring in series (9a-i) to maintain crucial hydrogen bonding interactions with the Phe295 residue in the enzyme's active site.

A Novel Ultrasensitive Second Derivative Synchronous Spectrofluorimetric Approach for the Simultaneous Analysis of the Co-Administered Antihypertensives, Telmisartan and Carvedilol in Biological Fluids and Tablets: Greenness and Blueness Assessment.

Hypertension is the predominant risk factor for cardiovascular diseases and mortality. This study presents the first method for the simultaneous analysis of the co-administered antihypertensive drugs, Carvedilol (CAR) and Telmisartan (TEL) using a fast, highly sensitive, environmentally friendly, and cost-effective second derivative synchronous spectrofluorimetric approach. The fluorescence of CAR and TEL was quantified at 243 nm and 274.

RETRACTED: El-Far et al. Thymoquinone and Curcumin Defeat Aging-Associated Oxidative Alterations Induced by D-Galactose in Rats' Brain and Heart. 2021, , 6839.

The retracts the article "Thymoquinone and Curcumin Defeat Aging-Associated Oxidative Alterations Induced by D-Galactose in Rats' Brain and Heart" [...

Enhancing Photothermal Therapy for Antibiofilm Wound Healing: Insights from Graphene Oxide-Cranberry Nanosheet Loaded Hydrogel in vitro, in silico, and in vivo Evaluation.

Background: Diabetic foot ulcers present a formidable challenge due to colonization by biofilm-forming microorganisms, heightened oxidative stress, and continuous wound maceration caused by excessive exudation.

Methods: To address these issues, we developed a robust, stretchable, electro-conductive, self-healing, antioxidant, and antibiofilm hydrogel. This hydrogel was synthesized through the crosslinking of polyvinyl alcohol (PVA) and chitosan (CH) with boric acid.

Identification of Coumarin-Chalcone and Coumarin-Pyrazoline Derivatives as Novel Anti- Agents.

Introduction: Toxoplasmosis, a zoonotic infection caused by the apicomplexan parasite , affects a significant portion of the global human population. This condition, particularly dangerous for pregnant women and immunocompromised individuals, currently lacks effective treatment options.

Methods:  Eighteen coumarin-based derivatives were synthesized, comprising coumarin-chalcone hybrids (5a-i) and coumarin-pyrazoline hybrids (6a-i).

Response of to zinc and silicon nanoparticles and pollen extract as alternates to traditional fertilizers.

is used in a variety of medicinal and aromatic products. The effects of various treatments on sage () plants were investigated in an open-field experiment conducted between 2021 and 2022. During the experiment, ZnO nanoparticles (NPs) were used at concentrations of 1.

A Modified Green Star Area (MoGSA) and software to assess greenness of reactions in the chemistry laboratories.

The environmental and health impacts of chemical processes have been a growing concern, leading to the establishment of Green Chemistry principles. Introducing new metrics for the assessment of methods' greenness is crucial to evaluate the exerted efforts to conserve the environment. In this work, we introduce a Modified Green Star Area (MoGSA) and software to assess the greenness of chemical reactions in laboratory settings.

Molecular insights into the physiological impact of low-frequency noise on sea slug Onchidium reevesii: Activation of p53 signaling and oxidative stress response.

To investigate the regulatory role of tumor protein p53 of sea slug (Onchidium reevesii) under oxidative stress conditions, we examined the response mechanisms of O. reevesii to low-frequency noise pollution (1000 Hz) using molecular and cellular biology techniques. We successfully cloned the O.

Identification and Analysis of Autophagy-Related Genes as Diagnostic Markers and Potential Therapeutic Targets for Tuberculosis Through Bioinformatics.

According to the World Health Organization, infections affect approximately 25% of the world's population. There is mounting evidence linking autophagy and immunological dysregulation to tuberculosis (TB). As a result, this research set out to discover TB-related autophagy-related biomarkers and prospective treatment targets.

Development of anti-bacterial bio-transfer double sheet layer of polyvinyl alcohol/carboxymethyl cellulose films infused with Astragalus tribuloides leaf extract for beef burgers preservation.

This study was conducted to develop biodegradable films using a combination of carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA) and purified leaves extract of Astragalus tribuloides (ATE). Various traits of the films, including their morphology description, thermal behavior, tensile/elongation properties and physical characteristics were examined. The scanning electron microscope (SEM) photographs showed smooth surface with small amounts of ATE, but rougher with higher concentrations of 1.

Evaluation of one-shot vincristine sulfate combined with surgical excision as a new regimen for treatment of canine transmissible venereal tumor.

Objective: The purpose of this study was to investigate the effectiveness of surgical excision combined with a single shot of vincristine sulfate for treating transmissible venereal tumor (TVT) in dogs.

Materials And Methods: Fifty-two dogs were divided randomly into two groups ( 26). Dogs in Group I were treated surgically by debulking the tumorous mass, whereas dogs in Group II were subjected to a combination of surgery and a single injection of vincristine sulfate.