9,108 results match your criteria: "KTH Royal Institute of Technology; jesper.gantelius@scilifelab.se.[Affiliation]"

Eco-friendly and strong lignin-containing microfibrillated cellulose films for high-performance separators of aqueous zinc batteries.

Int J Biol Macromol

December 2024

KTH-Royal Institute of Technology, Department of Fiber and Polymer Technology, Teknikringen 56-58, Stockholm SE-100 44, Sweden; KTH-Royal Institute of Technology, Wallenberg Wood Science Center - WWSC, Department of Fiber and Polymer Technology, Teknikringen 56-58, Stockholm SE-100 44, Sweden. Electronic address:

Aqueous zinc-ion batteries have gained significant interest, offering several distinct advantages over conventional lithium-ion batteries owing to their compelling low cost, enhanced battery safety, and excellent environmental friendliness. Nevertheless, the unfortunate growth of zinc dendrites during cycling leads to poor electrochemical performance of zinc batteries, primarily attributed to the diminished wet mechanical properties and limited electrolyte uptake of existing commercial separators. Herein, a bio-based separator was developed from sustainable resources using natural polymers derived from wood pulp to replace fossil-based polyolefin separators.

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How to build the virtual cell with artificial intelligence: Priorities and opportunities.

Cell

December 2024

Chan Zuckerberg Initiative, Redwood City, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Applied Physics, Stanford University, Stanford, CA, USA. Electronic address:

Article Synopsis
  • Cells are crucial for studying health and diseases, but traditional models are limited in their ability to accurately represent cell function and behavior.
  • Advances in AI and omics technology enable the development of AI virtual cells (AIVCs), complex models that simulate molecular, cellular, and tissue behavior across various conditions.
  • The creation of AIVCs aims to enhance biological research by allowing detailed simulations, speeding up discoveries, and promoting collaborative and interdisciplinary approaches in open scientific research.
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Differences between two maximal principal strain rate calculation schemes in traumatic brain analysis with in-vivo and in-silico datasets.

J Biomech

January 2025

Department of Bioengineering, Stanford University, CA, 94305, USA; Department of Neurology, Stanford University, Stanford, CA 94305, USA; Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.

Brain deformation caused by a head impact leads to traumatic brain injury (TBI). The maximum principal strain (MPS) was used to measure the extent of brain deformation and predict injury, and the recent evidence has indicated that incorporating the maximum principal strain rate (MPSR) and the product of MPS and MPSR, denoted as MPS × SR, enhances the accuracy of TBI prediction. However, ambiguities have arisen about the calculation of MPSR.

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Griseofulvin represents a rare case of a close-packed organic apohost that can clathrate selected volatile guests in a solid-gas fashion. Inclusion mechanisms and solvent exchange were investigated by a combination of single crystal and powder X-ray diffraction, coupled to optical microscopy and thermal analyses. In particular, gas diffusion and dissolution/recrystallization are alternatively observed, depending on the host polymorph, as well as the chemical nature of the guest and its physical state.

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Recent reports of room-temperature, ambient pressure superconductivity in copper-substituted lead phosphate apatite, commonly referred to as LK99, have prompted numerous theoretical and experimental studies into its properties. As the electron-phonon interaction is a common mechanism for superconductivity, the electron-phonon coupling strength is an important quantity to compute for LK99. In this work, we compare the electron-phonon coupling strength among the proposed compositions of LK99.

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Background: The effect of varying brain ventricular volume on the cerebrospinal fluid (CSF) proteome has been discussed as possible confounding factors in comparative protein level analyses. However, the relationship between CSF volume and protein levels remains largely unexplored. Moreover, the few existing studies provide conflicting findings, indicating the need for further research.

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This study aimed to investigate the effect of eccentric exercise on exercise-induced muscle damage (EIMD) and inflammation on high-altitude-induced venous gas emboli (VGE). Subjects were exposed to an altitude of 24,000 ft. for 90 min, with either prior eccentric exercise (ECC) or no exercise (Control) 24 h before.

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Understanding the rapidly evolving landscape of single-cell and spatial omic technologies is crucial for advancing biomedical research and drug development. We provide a living review of both mature and emerging commercial platforms, highlighting key methodologies and trends shaping the field. This review spans from foundational single-cell technologies such as microfluidics and plate-based methods to newer approaches like combinatorial indexing; on the spatial side, we consider next-generation sequencing and imaging-based spatial transcriptomics.

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Although being able to determine whether a host molecule can enclose a guest molecule and form a caging complex could benefit numerous chemical and medical applications, the experimental discovery of molecular caging complexes has not yet been achieved at scale. Here, we propose MoleQCage, a simple tool for the high-throughput screening of host and guest candidates based on an efficient robotics-inspired geometric algorithm for molecular caging prediction, providing theoretical guarantees and robustness assessment. MoleQCage is distributed as Linux-based software with a graphical user interface and is available online at https://hub.

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The Human Pathology Atlas for deciphering the prognostic features of human cancers.

EBioMedicine

January 2025

Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm SE-17165, Sweden; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 9RT, UK. Electronic address:

Background: Cancer is one of the leading causes of mortality worldwide, highlighting the urgent need for a deeper molecular understanding and the development of personalized treatments. The present study aims to establish a solid association between gene expression and patient survival outcomes to enhance the utility of the Human Pathology Atlas for cancer research.

Methods: In this updated analysis, we examined the expression profiles of 6918 patients across 21 cancer types.

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Engineering skyrmion from spin spiral in transition metal multilayers.

J Phys Condens Matter

December 2024

Department of Physics and Nanotechnology, SRM Institute of Science and Technology, Kattankulathur, 603203 Chennai, Tamil Nadu, India.

Skyrmions having topologically protected field configurations with particle-like properties play an important role in various fields of science. Our present study focus on the generation of skyrmion from spin spiral in the magnetic multilayers of 4d/Fe/Ir(111) with 4d = Y, Zr, Nb, Mo, Ru, Rh. Here we investigate the impact of 4d transition metals on the isotropic Heisenberg exchanges and anti-symmetric Dzyaloshinskii-Moriya interactions originating from the broken inversion symmetry at the interface of 4d/Fe/Ir(111) multilayers.

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Printed Thin Magnetic Films via Ternary Hybrid Diblock Copolymer Films Containing Magnetic Iron Oxide and Nickel Nanoparticles.

ACS Appl Mater Interfaces

December 2024

TUM School of Natural Sciences, Department of Physics, Chair for Functional Materials, Technical University of Munich, James-Franck-Street 1, 85748 Garching, Germany.

Ternary hybrid thin films composed of a diblock copolymer templating two types of nanoparticles (NPs) expand the functionality of binary systems, which renders them interesting for magnetic sensing or magnetic data storage applications. Herein, one-pot slot-die printed hybrid polystyrene--poly(methyl methacrylate) (PS--PMMA) thin films are prepared with iron oxide (magnetite, FeO, = 20 nm) and nickel NPs (Ni, = 46 nm) in one step by the advanced slot-die coating technique, which facilitates upscaling of fabrication. The evolution of the hybrid film morphology is probed with in situ grazing-incidence small-angle X-ray scattering and compared to that of a PS--PMMA thin film without NPs.

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Objective: This study was to investigate alterations in contractile properties of the ankle plantar- and dorsiflexors in post-stroke individuals. The correlation between muscle architecture parameters and contractile properties was also evaluated.

Methods: Eight post-stroke individuals and eight age-matched healthy subjects participated in the study.

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Objective: The genomic effects of biomechanical loading on human growth plate cartilage are unknown so far. To address this, we used rare human growth plate biopsies obtained from children undergoing epiphysiodesis and exposed them to precisely controlled mechanical loading using a microloading device. The biopsies were cultured 24 hours after mechanical loading, followed by RNA-sequencing analyses to decipher the genomic regulation.

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Climate worry: associations with functional impairment, pro-environmental behaviors and perceived need for support.

BMC Psychol

December 2024

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Sweden.

Background: A large proportion of individuals experience functional impairment in everyday life due to climate worry. However, the current understanding of this functional impairment is limited by the use of suboptimal measures. Furthermore, it is not known whether functional impairment due to climate worry affects pro-environmental behaviors (PEBs) or whether individuals who experience such impairment perceive a need for support.

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ProHap enables human proteomic database generation accounting for population diversity.

Nat Methods

December 2024

Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.

Amid the advances in genomics, the availability of large reference panels of human haplotypes is key to account for human diversity within and across populations. However, mass spectrometry-based proteomics does not benefit from this information. To address this gap, we introduce ProHap, a Python-based tool that constructs protein sequence databases from phased genotypes of reference panels.

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Tumors escape immune detection and elimination through a variety of mechanisms. Here, we used prostate cancer as a model to examine how androgen-dependent tumors undergo immune evasion through downregulation of the major histocompatibility complex class I (MHCI). We report that response to immunotherapy in late-stage prostate cancer is associated with elevated MHC expression.

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Spatiotemporal Retention of Structural Color and Induced Stiffening in Crosslinked Hydroxypropyl Cellulose Beads.

Macromol Rapid Commun

December 2024

Department of Fibre and Polymer Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm, SE-100 44, Sweden.

Hydroxypropyl cellulose (HPC) is known for its ability to form cholesteric liquid crystalline phases displaying vivid structural colors. However, these vibrant colors tend to fade over time when the material dries. This issue is a major bottleneck to finding practical applications for these materials.

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The phytopathogenic oomycete Phytopythium helicoides, previously known as Pythium helicoides, has emerged as a new threat to the Shatangju citrus cultivar (Citrus reticulata cv. Shatangju; '' in Chinese) in southern China. To enable rapid diagnosis and control of the leaf blight and stem rot caused by P.

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Long-Range Surface Forces in Salt-in-Ionic Liquids.

ACS Nano

December 2024

Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

Ionic liquids (ILs) are a promising class of electrolytes with a unique combination of properties, such as extremely low vapor pressures and nonflammability. Doping ILs with alkali metal salts creates an electrolyte that is of interest for battery technology. These salt-in-ionic liquids (SiILs) are a class of superconcentrated, strongly correlated, and asymmetric electrolytes.

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The challenges presented by sour environments rich in hydrogen sulfide (HS) underscore the necessity for a comprehensive understanding of material behavior under such conditions. The cracking susceptibility of metals and alloys used for subsurface equipment in downhole oil and gas exploration operations is particularly concerning. The NACE Double Cantilever Beam (DCB) test has emerged as a widely used quality assurance tool in the petroleum industry, leveraging fracture mechanics principles to assess the environment-assisted cracking (EAC) resistance of metals and alloys.

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Water on land is essential for all societal, ecosystem, and planetary health aspects and conditions, and all life as we know it. Many disciplines consider and model similar terrestrial water phenomena and processes, but comparisons and consistent validations are lacking for the datasets used by various science communities for different world parts, scales, and applications. Here, we present a new global data synthesis that includes and harmonises four comparative datasets for main terrestrial water fluxes and storage changes, and the catchment-wise water balance closure they imply for the 30-year period 1980-2010 in 1561 non-overlapping hydrological catchments around the world.

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Traumatic brain injury (TBI) in cyclists is a growing public health problem, with helmets being the major protection gear. Finite element head models have been increasingly used to engineer safer helmets often by mitigating brain strain peaks. However, how different helmets alter the spatial distribution of brain strain remains largely unknown.

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Wire drawing is one of the oldest and most common cold metal forming processes. Wire is drawn through a single die or a set of conical dies to make it longer and stronger. In the drawing die there are three geometrical parameters that affect the drawing force: die diameter, die angle and bearing length.

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