Analysis of skew, examination of intercorrelations, and determining the optimal threshold for performance invalidity when 10 performance validity tests are administered during a neuropsychological evaluation.

Introduction: This study cross-validates and expands upon previous research by examining the optimal number of PVT failures necessary to determine invalid performance when 10 PVTs are administered during a neuropsychological evaluation. Additionally, the study assessed the degree of skewness of individual PVTs and PVT intercorrelations for the overall sample and by validity group.

Method: Participants were 283 adult neuropsychology outpatients evaluated at an academic medical center.

Altered fibrin clot properties and elevated von Willebrand factor are associated with progression to permanent atrial fibrillation: A cohort study.

Background: The role of a prothrombotic state in atrial fibrillation (AF) progression to permanent arrythmia (PerAF) is unclear. Formation of denser and poorly lysable fibrin clots has been observed in AF patients also with sinus rhythm in association with higher stroke risk. We investigated whether altered fibrin clot properties and other prothrombotic state markers may contribute to AF transition to PerAF.

DesiRNA: structure-based design of RNA sequences with a replica exchange Monte Carlo approach.

Designing RNA sequences that form a specific structure remains a challenge. Current computational methods often struggle with the complexity of RNA structures, especially when considering pseudoknots or restrictions related to RNA function. We developed DesiRNA, a computational tool for the design of RNA sequences based on the Replica Exchange Monte Carlo approach.

Effect of Soaking Treatments in Acid and Salt Solutions on Physicochemical, Structural, Thermal and Rheological Properties of Porang ( Blume) Flour.

Research Background: Porang ( Blume) contains a high amount of starch, glucomannan and Ca-oxalate. Soaking porang tuber in acid (citric acid) and salt (sodium chloride) solutions affects the Ca-oxalate content, functional, rheological and thermal properties of porang flour. The aim of this study is to thoroughly investigate the effect of soaking treatments in acid and salt solutions at different temperatures on the physicochemical, rheological and thermal properties, functional groups, molecular mass and morphology of porang flour.

A non-interventional biomarker study in patients with adenocarcinoma of the lung treated with nintedanib plus docetaxel following progression on chemotherapy and/or immunotherapy: LUME-BioNIS.

Background: Anti-angiogenic agents, such as nintedanib and ramucirumab, when combined with docetaxel, are subsequent treatment options in patients with non-small cell lung cancer (NSCLC) who have failed on first-line chemotherapy or immunochemotherapy. However, to date, there are no validated predictive biomarkers for efficacy of anti-angiogenic therapies in this setting. The aim of this study was to explore whether genetic or genomic markers, alone or combined with clinical covariates, could be used to predict overall survival (OS) in patients with NSCLC who are eligible for treatment with nintedanib plus docetaxel.

The interplay between mitochondrial DNA genotypes, female infertility, ovarian response, and mutagenesis in oocytes.

Study Question: Is there an association between different mitochondrial DNA (mtDNA) genotypes and female infertility or ovarian response, and is the appearance of variants in the oocytes favored by medically assisted reproduction (MAR) techniques?

Summary Answer: Ovarian response was negatively associated with global non-synonymous protein-coding homoplasmic variants but positively associated with haplogroup K; the number of oocytes retrieved in a cycle correlates with the number of heteroplasmic variants in the oocytes, principally with variants located in the hypervariable (HV) region and rRNA loci, as well as non-synonymous protein-coding variants.

What Is Known Already: Several genes have been shown to be positively associated with infertility, and there is growing concern that MAR may facilitate the transmission of these harmful variants to offspring, thereby passing on infertility. The potential role of mtDNA variants in these two perspectives remains poorly understood.

Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotype.

Two retrogene insertions, FGF4L1 (formerly 18-FGF4, colloquially CDPA) and FGF4L2 (formerly 12-FGF4, colloquially CDDY), have recently been discovered as determinants of short leg phenotype in dogs. This case study is comprised of a family of standard wirehaired dachshunds in which the dogs lacking the FGF4L1 gene exhibit a tall phenotype. The tall phenotype in the dachshunds of this report precludes the dog's working function of den work.

Systemic Circulation in Advanced Heart Failure and Cardiogenic Shock: State-of-the-Art Review.

The integrative physiology of the left ventricle and systemic circulation is fundamental to our understanding of advanced heart failure and cardiogenic shock. In simplest terms, any increase in aortic stiffness increases the vascular afterload presented to the failing left ventricle. The net effect is increased myocardial oxygen demand and reduced coronary perfusion pressure, thereby further deteriorating contractile function.

Ensemble Density Functional Theory of Ground and Excited Energy Levels.

A Kohn-Sham (KS) density-functional energy expression is derived for any (ground or excited) state within a given many-electron ensemble along with the stationarity condition it fulfills with respect to the ensemble density, thus giving access to both physical energy levels and individual-state densities, in principle exactly. We also provide working equations for the evaluation of the latter from the true static ensemble density-density linear response function. Unlike in Gould's recent ensemble potential functional approach to excited states [arXiv:2404.

Improving Glycemic Control via Heat Therapy in older adults at risk for Alzheimer's Disease (FIGHT-AD): a pilot study.

Impaired glycemic control increases the risk for type 2 diabetes (T2D) and Alzheimer's Disease (AD). Heat therapy (HT), via hot water immersion (HWI), has shown promise in improving shared mechanisms implicated in both T2D and AD, like blood glucose regulation, insulin sensitivity, and inflammation. The potential for HT to improve brain health in individuals at risk for AD has not been examined.

Physician Views and Attitudes Regarding Tobacco-Cessation Strategies for Patients with Rheumatoid Arthritis.

Objective: In this study, we explored physicians' level of experience with patients with rheumatoid arthritis (RA) who used tobacco; their views on the effects of tobacco use on the efficacy of RA treatments; and their experiences and attitudes with respect to tobacco cessation programs.

Methods: We conducted qualitative, semi-structured interviews of 20 physicians (10 primary-care physicians [PCPs] and 10 rheumatologists).

Results: The physicians had been in clinical practice for a mean of 9.

Interbreed variation of dairy cow milk in terms of specific proteome and lipidome for establishing criteria of milk selection.

Background: Ruminant milk is a very complex table food and naturally encrypted with different components possessing various health-promoting characteristics.

Aim: In the present study, we focused on breed-wise compositional difference in milk including various components and release of fatty acids and peptides during digestion.

Methods: First, milk samples were analysed using lactoscan LW milk analyser, MALDI-TOF and gas chromatography.

Myelin oligodendrocyte glycoprotein antibody-associated disease mimicking neuromyelitis optica spectrum disorder.

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and neuromyelitis optica spectrum disorders (NMOSD) are two rare autoimmune inflammatory demyelinating diseases involving the central nervous system, which are often seen with combined involvement of the optic nerve and spinal cord. MOGAD can be confused with multiple sclerosis or NMOSD, due to its clinical presentation that may be similar and its characteristic to progress with habitual attacks. Although the clinical course of the above-mentioned three diseases is similar, their diagnosis and management are different.

Examining the moderation of the relationship between socio-economic status and consumption intentions by food information labels.

Front-of-package-labelling needs to portray health and/or sustainability information effectively to all consumers in a way that is both effective and equitable. There is mixed evidence for the effectiveness of such labels based on socioeconomic status (SES). Framing health consequences in an intuitive manner could help to reduce disparities in label comprehension across SES.

Impact of a brief self-compassion intervention on state emotion dysregulation in self-reported generalized anxiety disorder.

Background And Objectives: The current study examined emotion dysregulation and self-compassion as an intervention in individuals with generalized anxiety disorder (GAD) symptoms.

Methods: College students who met criteria for GAD according to questionnaires and non-anxious controls participated in an anxious mood induction. Subsequently, participants were randomized to a self-compassion or control intervention.

Reducing heart failure events via individualized patient education program in patients with reduced ejection fraction.

Background: Disease management programs for heart failure (HF) often include various strategies such as medication management and lifestyle modifications, and are known to improve clinical outcomes.

Objectives: To evaluate the effectiveness of an individualized patient education program (IPEP) specifically designed for patients with reduced ejection fraction (HFrEF) on clinical outcomes.

Methods: In our prospective interventional study involving 164 patients, participants were divided into control (CG) and intervention (IG) groups.

The immunogenetic basis of severe herpes simplex infections in neonates and children: a review.

Human herpes simplex virus (HSV) is a double stranded DNA virus with two distinct types, HSV-1 and HSV-2. The global burden of HSV is high with an estimated 2/3 of the adult population seropositive for at least one of these types of HSV. HSV rarely causes life-threatening disease in immunocompetent children and adults.

Femoral neck system (FNS) versus 4 cannulated compression screws (CCSs) in the treatment of young patients with Pauwels type III femoral neck fracture: a retrospective comparative study.

Objective: This study aimed to evaluate the clinical effectiveness of the femoral neck system (FNS) compared to four cannulated compression screws (CCSs) for managing Pauwels type III femoral neck fractures in young patients.

Methods: A retrospective analysis was conducted on young patients with Pauwels type III femoral neck fractures treated at our hospital from January 2021 to December 2022. Patients were categorized into two groups based on their respective internal fixation methods: the FNS group (32 cases) and the CCSs group (41 cases).

The utility of split function testing in determining recovery of glomerular filtration rate after living kidney donation: a cohort study.

Background: A number of UK transplantation centres use isotope studies to estimate the relative contribution from each kidney in living kidney donor assessment. The evidence that the estimation of pre-donation split function of the non-donated kidney influences post-donation renal recovery is limited. The aim of this study was to analyse whether, in the context of other donor factors, the split function of the non-donated kidney predicts the percentage recovery of glomerular filtration rate (GFR) at one-year post-donation.

Dynamic Data-Driven Management of Atrial Fibrillation With Implantable Cardiac Monitors: The MONITOR AF Study.

Background: Implantable cardiac monitors (ICMs) provide valuable insights into managing atrial fibrillation (AF). Data suggest that ICMs increase AF detection, but their impact on management is still uncertain.

Objectives: To evaluate and compare the impact of ICMs on the clinical management of AF.

Predicting the risk of a high proportion of three/multiple pronuclei (3PN/MPN) zygotes in individual IVF cycles using comparative machine learning algorithms.

Background: The majority of machine learning applications in assisted reproduction have been focused on predicting the likelihood of pregnancy. In the present study, we aim to investigate which machine learning models are most effective in predicting the occurrence of a high proportion (>30 %) of 3PN/MPN zygotes in individual IVF cycles.

Methods: Eight machine learning algorithms were trained and compared, including the AdaBoost and Gaussian NB.

ReBreed21-ET: Evaluation of a rapid resynchronization program that allows timed embryo transfer every 21 days.

This study evaluated the efficiency of a rapid resynchronization of ovulation program to allow timed embryo transfer (TET) every 21d in heifer embryo recipients. Holstein heifers (n = 510) had synchronized ovulation using a modified 5d CoSynch program for a TET (D7) after induced ovulation (D0). After TET, heifers were blocked by number of previous TETs and randomized into one of two resynchronization of ovulation programs: Resynch28 (n = 279), a traditional resynch program for TET 35d after previous TET; or ReBreed21-ET, a program designed to allow TET 21d after previous TET.

Fibrinogen: a new player and target on the formation of pre-metastatic niche in tumor metastasis.

Tumor metastasis involves a series of complex and coordinated processes, which is the main cause of patient death and still a significant challenge in cancer treatment. Pre-metastatic niches (PMN), a specialized microenvironment that develops in distant organs prior to the arrival of metastatic cancer cells, plays a crucial role in driving tumor metastasis. The development of PMN depends on a complex series of cellular and molecular components including tumor-derived factors, bone marrow-derived cells, resident immune cells, and extracellular matrix.

Integrative Assessment of Mixture Toxicity of Household Chemicals Using the Toxic Unit Approach and Mode of Action.

Household chemicals used daily are often combined, leading to inhalation exposure to mixtures. However, methods for assessing their toxic effects are limited. This study proposes an in vitro assay strategy for evaluating household chemical mixtures using benzalkonium chloride (BKC) and didecyldimethylammonium chloride (DDAC), a common disinfectant.