Development of a Thermoresponsive Core-Shell Hydrogel for Sequential Delivery of Antibiotics and Growth Factors in Regenerative Endodontics.

Background: Regenerative endodontics requires an innovative delivery system to release antibiotics/growth factors in a sequential trend. This study focuses on developing/characterizing a thermoresponsive core-shell hydrogel designed for targeted drug delivery in endodontics.

Methods: The core-shell chitosan-alginate microparticles were prepared by electrospraying to deliver bone morphogenic protein-2 for 14 days and transforming growth factor-beta 1 (TGF-β1) for 7-14 days.

Endocrown: A Minimally Invasive Alternative to Conventional Fixed Prosthesis.

Endodontically treated teeth with compromised coronal tooth structure often require core build-ups with the support of radicular posts. In certain cases, the traditional post and core approach may not be possible due to various anatomical and clinical contraindications. Such cases require more meticulous planning and alternative treatment approaches for successful outcomes.

Reliability of ameloglyphics in forensic identification: a systematic review.

Background: Teeth are considered as hard tissue analogue to fingerprints, being unique to an individual. The enamel which forms the outer layer of the tooth is formed through a highly dynamic process in which ameloblasts lay down enamel rods in an undulating and intertwining path, which is reflected as a series of enamel rod pattern. The study of these patterns is termed as "Ameloglyphics".

Knowledge and awareness of child sexual abuse related to POCSO (Protection of Children from Sexual Offences) Act among medical and dental professionals in India: A cross-sectional study.

Background: The POCSO (Protection Of Children from Sexual Offences) Act was introduced in 2012 as a measure to safeguard and prevent interests of children affected by sexual crimes. Both medical and dental professionals are capable of identifying such cases.

Aim: The aim of this study was to evaluate the knowledge and awareness of child sexual abuse related to POCSO Act among both medical and dental professionals in India.

Religiosity vs tobacco use: Religion's impact on tobacco use among adult Indian population - A cross sectional study.

Background: Tobacco use is major serious threats to health and well-being killing approximately 1 million people each year. One of the better ways for tobacco cessation is by promoting the cultural-religious belief that may influence a person's tobacco-related habits.

Methods: A Descriptive cross-sectional study was conducted among 174 adult subjects of smoking and smokeless tobacco users.

Across-the-board review on Omicron SARS-CoV-2 variant.

Introduction: Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a cataclysmic pandemic. Several SARS-CoV-2 mutations have been found and reported since the COVID-19 pandemic began. After the Alpha, Beta, Gamma, and Delta variants, the Omicron (B.

Successful Treatment of Low-Flow Vascular Malformation in the Lip Using Intralesional Bleomycin: A Case Report.

Vascular malformations (VMs) are congenital abnormalities of blood or lymphatic vessels, present at birth and growing proportionally with the individual. They are classified into types such as capillary, venous, lymphatic, and arteriovenous malformation (AVMs). Symptoms include discoloration, swelling, pain, or functional impairment, depending on the type and location.

Aortic Root Pathologies and Surgical Management: Insights From a Single Surgeon's Experience.

Introduction and objectives The Bentall procedure is a surgical technique designed to address aortic root abnormalities, including issues with the aortic valve, aortic root, and ascending aortic disease. This study aimed to assess the short-term outcomes of 39 patients who underwent the Bentall and concomitant procedures: aortic root enlargement, personalized external aortic root support (PEARS), and Mini-Bentall procedures at a single center. Methodology We conducted a retrospective study involving 39 patients who underwent surgery for aortic root pathologies such as dissection, Marfan syndrome (MFS), bicuspid aortic valve, degenerative disease, and atherosclerosis at our hospital between January 2019 and September 2024.

Prevalence and Patterns of Polysubstance Use (Tobacco and Other Substances) and Associated Factors: A Cross-Sectional Analysis in a High-Risk Cohort for Oral Cancer in Varanasi, India, with a Special Focus on Young Emerging Adults.

Introduction: The dearth of population-based data on polysubstance use, especially in young emerging adults, presents a critical gap in understanding public health challenges, particularly in rural India, where tobacco and oral cancer are prevalent. This study addresses this gap by investigating the prevalence and patterns of substance use, with a focus on young emerging adults (18-29 years) within a high-risk cohort for oral cancer in Varanasi, India.

Methods: The study involved a cross-sectional analysis of baseline data from 10,101 participants within a high-risk cohort in rural settings of the Varanasi district between December 2020-June 2023.

Histopathological Assessment of Tricalcium Aluminate-free Mineral Trioxide Aggregate and Two Antibacterial Enhanced Mineral Trioxide Aggregates As Pulpotomy Agents in Rat Model.

Objective: To evaluate the effect of a newly developed MTA-based material and two antibacterial-enhanced MTAs as pulp capping materials in immature permanent dental elements underwent full pulpotomy.

Methods: The present animal study included 20 Wistar albino rats that, after full pulpotomy, were randomly divided into 4 groups receiving different MTA formulations as pulp capping materials: conventional MTA, Tricalcium aluminate (TCA)- free MTA, and MTA enhanced with metronidazole or doxycycline. Histopathological assessments were carried out at 7- and 28-days post-treatment to evaluate dentinal bridge formation, inflammatory reactions, pulp tissue necrosis and internal resorption.

Tissue Engineering 3D-Printed Scaffold Using Allograft/Alginate/Gelatin Hydrogels Coated With Platelet-Rich Fibrin or Adipose Stromal Vascular Fraction Induces Osteogenesis In Vitro.

Incorporating autologous patient-derived products has become imperative to enhance the continually improving outcomes in bone tissue engineering. With this objective in mind, this study aimed to evaluate the osteogenic potential of 3D-printed allograft-alginate-gelatin scaffolds coated with stromal vascular fraction (SVF) and platelet-rich fibrin (PRF). The primary goal was to develop a tissue-engineered construct capable of facilitating efficient bone regeneration through the utilization of biomaterials with advantageous properties and patient-derived products.

A state-of-the-art review of the recent advances in drug delivery systems for different therapeutic agents in periodontitis.

Periodontitis (PD) is a chronic gum illness that may be hard to cure for a number of reasons, including the fact that no one knows what causes it, the side effects of anti-microbial treatment, and how various kinds of bacteria interact with one another. As a result, novel therapeutic approaches for PD treatment must be developed. Additionally, supplementary antibacterial regimens, including local and systemic medication administration of chemical agents, are necessary for deep pockets to assist with mechanical debridement of tooth surfaces.

Management of Laryngoscope-Induced Iatrogenic Dental Injury: A Case Series.

Dental injury is a common anesthesia-related adverse event, with a high incidence of damage to teeth and surrounding tissues during oro-endotracheal intubation. Poor oral hygiene, compromised periodontium, faulty or loose prosthesis, proclined maxillary incisors along with increased difficulty level of airway management, improper use of laryngoscope, and use of maxillary anterior teeth as a fulcrum for achieving accessibility to the airway are all risk factors for iatrogenic dental injury. This type of injury provides additional physical and psychological trauma to patients who have already undergone medical surgical procedures.

Impact of cartoon-animated video, caregiver-supervised training, and pamphlet on plaque control, oral hygiene status, and oral hygiene knowledge, attitude, and practices in orphaned adolescents: A randomized controlled trial.

Aim: To evaluate the effectiveness of cartoon animated video, caregiver-supervised training, and pamphlet-based oral health education on plaque control, oral hygiene status, and oral health knowledge, attitude, and practice (KAP) among orphaned adolescents with plaque-induced gingivitis.

Methods: A total of ninety adolescents were randomly selected and allocated into three different groups. Group A received the pamphlet (n = 30), Group B received the cartoon animated video (n = 30), and Group C received the caregiver-supervised training (n = 30).

Parents' Willingness-to-Pay for Fissure Sealant and Fluoride Varnish Therapy in Public and Private Pediatric Clinics.

Aim: This study employed the willingness-to-pay (WTP) method to investigate parents' valuation of fissure sealant (FS) and fluoride varnish (FV) therapy.

Design: This cross-sectional analytical study was conducted in 2021 among 100 parents. The maximum WTP were collected using payment cards, an originally developed validated and reliable questionnaire, educational videos, and a hypothetical scenario.

Functional Class II Treatment Simultaneous With Selective Reduction of Talon Cusps: A Case Report.

Selective reduction of bilateral nonsyndromic talon cusps in an 11-year-old class II patient enabled successful mandibular repositioning with a twin block appliance. This approach achieved desired orthodontic outcomes without causing pain or sensitivity following reduction, highlighting a novel strategy for managing talon cusps in orthodontic treatment.

Custom Ocular Prosthesis With Intraoral Obturator for Orbital and Intraoral Defects Resulting From Mucormycosis: A Technical Case Report.

Orbital defects can result from a myriad of underlying diseases and injuries. Treatment of malignant neoplasms and maxillofacial trauma are common reasons for orbital exenteration. Recently, a growing number of cases of orbital defects have been reported due to mucormycosis in patients with COVID-19.

The unseen perils of oral-care products generated micro/nanoplastics on human health.

The extensive use of plastics in modern dentistry, including oral care products and dental materials, has raised significant concerns due to the increasing evidence of potential harm to human health and the environment caused by the unintentional release of microplastics (MPs) and nanoplastics (NPs). Particles from sources like toothpaste, toothbrushes, orthodontic implants, and denture materials are generated through mechanical friction, pH changes, and thermal fluctuations. These processes cause surface stress, weaken material integrity, and induce wear, posing health risks such as exposure to harmful monomers and additives, while contributing to environmental contamination.

Oral health status among lorry drivers in Hyderabad city - A cross sectional study.

Background: Lorry drivers work tirelessly behind the wheels, commuting from one place to another without regular and adequate food, rest and sleep. These people often have odd working hours, long work shifts with frequent changes to their work schedule. In addition, they work in unfavorable climate conditions and face variety of problems like traffic congestions, vehicle fumes, vibrations and poor conditions of roads.

Evaluation of salivary biomarker interleukin-6 in oral squamous cell carcinoma and oral potentially malignant disorders - A comparative cross-sectional South Indian study.

Background: Oral squamous cell carcinoma (OSCC) accounts for nearly 90% of oral malignancies and represents a major global health care problem. It is often preceded by oral potentially malignant disorders (OPMD). Although regular clinical examination forms the backbone for oral cancer screening, subtle lesions go unnoticed and there is a need for more sensitive and specific molecular biomarkers in mass screening of population.

Evaluation of antifungal efficacy of albedo extract of on - An study.

Introduction: The study aims to investigate the antifungal efficacy of albedo extract of Punica grantum on candida albicans by evaluating the inhibitory capacity of alcoholic albedo extracts by disc diffusion method and by comparing the antifungal efficacy of alcoholic extract of albedo with clotrimazole and ethanol.

Methods: Using a conventional disc diffusion method, the effectiveness of Punica Granatum albedo extract against Candida albicans was assessed and evaluated depending on the presence or absence of inhibition zones, as well as the average diameter of inhibition zones. Albedo extract of Punica granatum serial dilutions were prepared ranging from 1%, 5%, 10%, 15%, 20% and 25% and its antifungal efficacy was tested against Candida albicans in comparison with clotrimazole and ethanol.

Comparing the release of growth factors when partially demineralized tooth matrix is mixed with platelet rich fibrin and injectable platelet rich fibrin: An observational study.

Context: Platelet concentrates are rich in growth factors that assist in regenerative medicine to promote healing and tissue regeneration. Similarly, partially demineralized tooth is a storehouse of many growth factors, assisting in bone regeneration. Hence, the present study aimed to quantify the release of growth factors from different platelet concentrates individually and when mixed with a partially demineralized tooth matrix.

From teeth to ethnicity: A neural network approach to predicting population of origin through dental traits and anomalies.

Background: This study aimed to investigate the prevalence of dental traits and anomalies in five North Indian populations (Khas Bodhi, Jaat, Khatri, Garhwali, and Gujjar) and predict the population of origin based on these traits and anomalies for forensic applications.

Methods: We assessed dental traits and anomalies in 454 individuals through intraoral examination. Neural network analysis was employed to predict the population of origin based on a combination of dental traits and anomalies.

QuPath for automated analysis of digital images of oral epithelial dysplasia.

Objectives: Grading of oral epithelial dysplasia (OED) has been plagued with intra-observer and inter-observer variations. To overcome this subjectivity, a more objective digital image analysis is obligatory using computer-aided software. The use of open-source software like QuPath, which is a new bio-image evaluation software program, may fulfil this growing need in virtual pathology.