3,989 results match your criteria: "K.F.; the Centers for Disease Control and Prevention[Affiliation]"

Pseudogap Effects in the Strongly Correlated Regime of the Two-Dimensional Fermi Gas.

Phys Rev Lett

October 2024

Center for Theoretical Physics, Sloane Physics Laboratory, Yale University, New Haven, Connecticut 06520, USA.

The two-species Fermi gas with attractive short-range interactions in two spatial dimensions provides a paradigmatic system for the understanding of strongly correlated Fermi superfluids in two dimensions. It is known to exhibit a BEC to BCS crossover as a function of ln(k_{F}a), where a is the scattering length, and to undergo a Berezinskii-Kosterlitz-Thouless superfluid transition below a critical temperature T_{c}. However, the extent of a pseudogap regime in the strongly correlated regime of ln(k_{F}a)∼1, in which pairing correlations persist above T_{c}, remains largely unexplored with controlled theoretical methods.

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Three-Year Outcomes Following TAVR in Younger (<75 Years) Low-Surgical-Risk Severe Aortic Stenosis Patients.

Circ Cardiovasc Interv

November 2024

Department of Interventional Cardiology and Cardiothoracic Surgery, Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, TX (N.S.K., M.J.R.).

Article Synopsis
  • A study compared transcatheter aortic valve replacement (TAVR) with traditional surgery in low-risk patients under 75 years old with severe aortic stenosis to evaluate safety and effectiveness over three years.* -
  • Results showed that TAVR patients had similar overall mortality rates but significantly fewer disabling strokes (0.6%) compared to surgery patients (2.9%), while TAVR also resulted in better valve performance.* -
  • Both treatment options had comparable low rates of valve reinterventions, but TAVR patients experienced higher rates of pacemaker implantation (21.0% vs. 7.1%).*
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Objective: To investigate if a positive result on ReceptivaDx for evaluation of B-cell lymphoma 6 (BCL6), a proposed marker of progesterone resistance associated with impaired uterine receptivity, correlates with a suboptimal profile of receptivity-associated markers in the window of implantation using the endometrial receptivity array and single-nucleus transcriptomic analysis.

Design: Retrospective clinical cohort study; pilot study of single-nucleus RNA sequencing of prospectively collected window of implantation endometrium undergoing ReceptivaDx BCL6 evaluation.

Setting: Academic center.

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Developing a Job-Exposure Matrix for Sedentary Behavior: A Study Based on the Inpatient Clinico-Occupational Database of Rosai Hospital Group.

J Occup Environ Med

January 2025

From the Department of Preventive Medicine, Tokai University School of Medicine, Isehara, Japan (K.F., Y.F., S.N., M.T.); Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan (K.S., R.T., T.N.); Department of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan (N.K.); Center for Health Informatics Policy, National Institute of Public Health, Wako, Japan (K.H.); Department of Hygiene, Kitasato University School of Medicine, Sagamihara, Japan (K.H.); and Chugoku Rosai Hospital Research Center for the Promotion of Health and Employment Support, Japan Organization of Occupational Health and Safety, Hiroshima, Japan (A.T.).

Article Synopsis
  • A job-exposure matrix was created to analyze sedentary behavior in relation to non-communicable diseases, using data from over 41,000 individuals.
  • The matrix was applied to a large cohort in a case-control study, revealing a connection between higher sedentary time and increased risks of diabetes, heart attacks, and endometrial cancer, while suggesting lower stroke risks.
  • The findings emphasize the need to address sedentary behavior in workplace settings due to its significant health implications.
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Article Synopsis
  • Recent advancements in aging research and drug discovery connect basic research with clinical applications, aiming to promote healthy longevity in humans.* -
  • The Aging Research and Drug Discovery Meeting in 2023 highlighted key areas such as AI, biomarkers, geroscience, and clinical trials focused on enhancing healthspan.* -
  • The meeting emphasized the importance of combining generative AI with innovative biological technologies to tackle age-related diseases and extend healthy lifespans.*
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A pH-responsive fluorescent film with the smartphone-assistance for real-time and visual detection of food freshness.

Food Chem

February 2025

SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Liaoning Key Lab for Aquatic Processing Quality and Safety, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China. Electronic address:

Monitoring food freshness is considerably important for food safety. In this study, a smart pH-responsive fluorescence hydroxypropyl methyl cellulose-κ-carrageenan-fluorescein isothiocyanate-NH-CaAlO (H-K-F-N) film was prepared. Taking synergetic advantage of the pH-dependent behavior of fluorescein isothiocyanate dye and the luminescence characteristics of calcium aluminate phosphor, the film exhibited a unique strong pH-responsive fluorescence with an exceptional linear relationship (correlation coefficient, R = 0.

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The addition of carbon-rich materials, such as raw feedstocks (RAW) and biochars, to agricultural soils is on the rise. This activity has many advantages, such as improving fertility, increasing water retention, and sequestering carbon. However, they can also increase the sorption of residual herbicides in the soil, reducing the effectiveness of weed control.

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Background: Lung quantitative computed tomography (qCT) severe asthma clusters have been reported, but their replication and underlying disease mechanisms are unknown. We identified and replicated qCT clusters of severe asthma in two independent asthma cohorts and determined their association with molecular pathways, using radiomultiomics, integrating qCT, multiomics and machine learning/artificial intelligence.

Methods: We used consensus clustering on qCT measurements of airway and lung CT scans, performed in 105 severe asthmatic adults from the U-BIOPRED cohort.

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Article Synopsis
  • Previous studies show that many healthcare providers overestimate the risks of radiation from imaging during pregnancy, leading to a reluctance to perform necessary imaging, even when it could greatly benefit patient care.
  • This study aimed to assess current knowledge and confidence levels regarding imaging pregnant patients among various medical specialists through an anonymous survey, including radiologists and OB/GYN providers.
  • The survey results revealed a general correct response rate of 68.5% across 18 questions, highlighting significant variability in knowledge, with some questions showing low correct response rates and most respondents feeling only "fairly" confident in their imaging decisions.
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  • Epinephrine in arthroscopic irrigation improves surgeon-rated visual clarity in shoulder surgeries, and subacromial injections are also explored for their effects.
  • A study aimed to determine if preoperative subacromial injections of epinephrine enhance surgeon visualization during arthroscopic shoulder surgery, hypothesizing that it would lead to better outcomes.
  • In a randomized controlled trial with 60 patients, while the epinephrine group reported slightly better visual clarity scores, the difference was not statistically significant, indicating no clear advantage over the control group.
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Article Synopsis
  • Deep brain stimulation has greatly advanced the treatment of neurological and psychiatric disorders, and there's interest in finding less invasive alternatives.
  • The study focuses on magnetoelectric nanodiscs (MENDs) that can convert magnetic fields into electric signals to modulate neurons remotely, showing effective results even below traditional stimulation thresholds.
  • When injected into specific brain regions of mice, MENDs can control behaviors related to reward and movement, paving the way for new applications in neuroscience research and therapy.
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Pharmacokinetics and Pharmacodynamics of Natalizumab 6-Week Dosing vs Continued 4-Week Dosing for Relapsing-Remitting Multiple Sclerosis.

Neurol Neuroimmunol Neuroinflamm

December 2024

From the Rocky Mountain MS Clinic (J.F.F.), Salt Lake City, UT; Department of Neurology (G.D.), Centre Hospitalier Universitaire de Caen, France; Hackensack Meridian Medical Group - Neurology (L.Z.R.), Jersey Shore University Medical Center, Neptune City, NJ; Mellen MS Center (J.A.C.), Neurological Institute, Cleveland Clinic, OH; Montréal Neurological Institute (D.L.A.), McGill University; NeuroRx Research (D.L.A.), Montréal, Quebec, Canada; Department of Neuroscience (H.B.), Central Clinical School, Monash University, Melbourne, Victoria, Australia; University of Alabama at Birmingham (G.R.C.), School of Public Health; Blizard Institute (G.G.), Barts and The London School of Medicine and Dentistry; Queen Mary University of London (G.G.), United Kingdom; Department of Neurology (J.K.), Amsterdam University Medical Centers, Vrije Universiteit, Netherlands; Department of Neurology with Institute of Translational Neurology (H.W.), University of Münster, Germany; Biogen (K.L., L.D., M.T., K.F., J.S., T.L.), Cambridge, MA; and Ashfield MedComms (H.E.), Middletown, CT.

Article Synopsis
  • * Results from the NOVA clinical trial show that while patients on Q6W dosing had lower levels of natalizumab compared to Q4W dosing, they still maintained significant clinical efficacy with most patients experiencing stable disease markers over 72 weeks.
  • * Key findings included a 23.6% increase in soluble vascular cell adhesion molecule-1 (sVCAM-1) levels in the Q6W
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Modeling the conformational heterogeneity of protein-small molecule systems is an outstanding challenge. We reasoned that while residue level descriptions of biomolecules are efficient for de novo structure prediction, for probing heterogeneity of interactions with small molecules in the folded state an entirely atomic level description could have advantages in speed and generality. We developed a graph neural network called ChemNet trained to recapitulate correct atomic positions from partially corrupted input structures from the Cambridge Structural Database and the Protein Data Bank; the nodes of the graph are the atoms in the system.

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Assessing excimer far-UVC (222 nm) irradiation for advanced oxidation processes: Oxidants photochemistry and micropollutants degradation.

Water Res

December 2024

Key Laboratory of Microorganism Application and Risk Control of Shenzhen, Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental Safety, Shenzhen Key Laboratory of Ecological Remediation and Carbon Sequestration, Institute of Environment and Ecology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. Electronic address:

Article Synopsis
  • The KrCl* excimer lamp (UV222) is a mercury-free alternative to low-pressure mercury lamps (UV254) for UV-based advanced oxidation processes, offering higher photon energy and better performance.
  • A comprehensive study was conducted on various oxidants like hydrogen peroxide and persulfate, revealing that UV222 significantly enhances oxidant activation, with increased efficacy for degrading micropollutants compared to UV254.
  • PDS proved to be the most effective oxidant under UV222, achieving much higher rates of micropollutant elimination and requiring less energy, despite some interference from other water constituents.
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Xylem embolism induced by freeze-thaw and drought are influenced by different anatomical traits in subtropical montane evergreen angiosperm trees.

Physiol Plant

October 2024

Guangxi Key Laboratory of Forest Ecology and Conservation, College of Forestry, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, Guangxi, China.

Subtropical evergreen broadleaved forests distributed in montane zones of southern China experience seasonal droughts and winter frost. Previously, studies have recognized that xylem anatomy is a determinant of its vulnerability to embolism caused by drought and freezing events. We hypothesized that there is a coordination of xylem resistance to freeze-thaw and drought-induced embolism for the subtropical montane evergreen broadleaved tree species because they are influenced by common xylem structural traits (e.

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Article Synopsis
  • Scientists tested a new treatment for chronic cough using a special spray that contains alkaline salts to help soothe the throat and airways.
  • They did a study with 12 people who had bad coughs, comparing the effects of this treatment with regular saline instead.
  • Results showed that the alkaline spray reduced coughing by up to 35%, especially the version with a pH of 9, and nobody had negative side effects.
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Generation of human-pig chimeric renal organoids using iPSC technology.

Commun Biol

October 2024

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Article Synopsis
  • Researchers are exploring porcine organs and human iPSC-derived organoids as potential alternatives for human transplants, but face technical challenges.
  • They successfully created human-pig chimeric renal organoids using modified culture systems, leading to continuous kidney development across species.
  • This advancement lays groundwork for future clinical applications, making it possible to develop humanized kidneys for transplantation purposes.
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Bio-adsorption of Fe (II) by dry biomass of metal-tolerant haloarchaeon Haloferax alexandrinus GUSF-1.

Braz J Microbiol

December 2024

Microbiology Discipline, School of Biological Sciences and Biotechnology, Goa University, Taleigao Plateau, Goa, Panaji, 403206, India.

Mining-associated activities result in iron pollution exceeding the acceptable limit of 0.3 mg L and are rampant in estuarine soil and water bodies that harbor halophilic microorganisms. Biotechnologies are underway to unveil the concentrations and recover the metals that skip existing physico-chemical methods.

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Article Synopsis
  • The research focuses on improving the diagnosis of subscapularis muscle injuries using artificial intelligence and magnetic resonance imaging (MRI) techniques, recognizing that these injuries are more common than previously thought.
  • It involves a multicenter study with 384 patients, utilizing various MRI sequences to analyze the shoulder joint for accurate identification of injuries, employing advanced radiomic analysis for enhanced diagnostic precision.
  • The ultimate goal is to refine preoperative assessments to potentially improve surgical outcomes and patient care in treating rotator cuff injuries.
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Study Question: Can oocyte functionality be assessed by observing changes in their intracytoplasmic lipid droplets (LDs) profiles?

Summary Answer: Lipid profile changes can reliably be detected in human oocytes; lipid changes are linked with maternal age and impaired developmental competence in a mouse model.

What Is Known Already: In all cellular components, lipid damage is the earliest manifestation of oxidative stress (OS), which leads to a cascade of negative consequences for organelles and DNA. Lipid damage is marked by the accumulation of LDs.

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Anticoagulation vs Antiplatelets Across Subgroups of Embolic Stroke of Undetermined Source: A Meta-Analysis of Randomized Controlled Trials.

Neurology

November 2024

From the Department of Neurology (M.G., Q.N.A., A.A.), University of Iowa Hospitals & Clinics, Iowa City; Department of Neurology (A.M.A.-Q.), University of Pittsburgh Medical Center, PA; Departments of Biostatistics (R.K.), Neurology (W.T.L., D.T.) and Epidemiology (W.T.L.), University of Washington, Seattle; Department of Internal Medicine (G.N.), Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece; Hardin Library for the Health Sciences (C.A.C.), The University of Iowa, Iowa City; Department of Cardiology and Angiology (T.K., T.G.), and Institute for Clinical Epidemiology and Applied Biometry (L.M.S.-H.), Faculty of Medicine, Eberhard Karls University Tübingen, Germany; Department of Neurology (K.F., S.Y.), Brown University, Providence, RI; Department of Neurology (J.L.S.), University of California at Los Angeles (UCLA); Department of Neurology (S.E.K.), University of Pennsylvania, PA; Department of Neurology (M.S.V.E.), Vagelos College of Physicians and Surgeons; Department of Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology & Stroke (S.P.), and Hertie Institute for Clinical Brain Research (S.P.), Eberhard Karls University Tübingen, Germany; and Department of Neurology (H.K.), Weill Cornell Medicine, New York, NY.

Article Synopsis
  • The study focuses on patients with ischemic stroke classified as embolic stroke of undetermined source (ESUS), highlighting the need for personalized treatment options between anticoagulation and antiplatelet therapy for secondary prevention.
  • A meta-analysis of 7 trials with nearly 15,000 patients showed that, overall, anticoagulation did not significantly reduce the risk of recurrent ischemic stroke compared to antiplatelet therapy.
  • However, in patients with a patent foramen ovale (PFO), anticoagulation demonstrated improved outcomes, while results varied for those with left atrial enlargement (LAE) depending on whether cardiac monitoring was allowed after randomization.*
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Eculizumab Use in Neuromyelitis Optica Spectrum Disorders: Routine Clinical Care Data From a European Cohort.

Neurology

November 2024

From the Department of Neurology (M.R., K.F., S.G.M., O.A.), Medical Faculty; Department of Neurology (M.R.), Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich-Heine-University Düsseldorf; Experimental and Clinical Research Center (S.A., F.P., J.B.-S.), a Cooperation Between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin; Charité - Universitätsmedizin Berlin (S.A., F.P., J.B.-S.), corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (S.A., F.P., J.B.-S.), Berlin; Department of Neurology (G.L.), Johanna Etienne Hospital, Neuss; Center for Translational Neuro- and Behavioral Sciences (R.P., J.S., C.K.), University Medicine Essen, University of Duisburg-Essen; Department of Neurology (L.R., L.K.), University Hospital, Münster; Department of Neurology (K.G., A.B.), School of Medicine and Health, Technical University of Munich, Klinikum Rechts der Isar; Department of Neurology and Institute of Neuroimmunology and MS (INIMS) (V.H.), University Medical Center Hamburg-Eppendorf; Department of General Pediatrics (M.K.), Neonatology and Pediatric Cardiology, University Children's Hospital, Medical Faculty, Heinrich-Heine-University Düsseldorf; Department of Neurology (K.H., R.G., I.A.), St. Josef-Hospital, Ruhr University Bochum; Department of Neurology (C.O., K.R.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität and Humboldt-Universität zu Berlin; Center of Clinical Neuroscience (T.Z.), Department of Neurology, Dresden; Department of Neurology (A.E.)Halle; Department of Neurology (V.R., F.T.N.), Erlangen; Department of Neurology (K.A., R.L.), Regensburg; Department of Neurology (S.A.L., C.W.), University Hospital, Köln; Department of Neurology (S.J., M.K.-K., B.W.), Molecular Neuroimmunology Group, University of Heidelberg; Department of Neurology (S.W.), Gießen; Department of Neurology (M.Seipelt), Marburg; Department of Neurology (Y.Y.), Frankfurt; Department of Neurology (N.R., U.K.Z.), Rostock, Germany; Department of Neurology (P.S.R.), Medical University of Vienna, Austria; Department of Neurology (M.C.K.), University Hospital, Tübingen; Section of Translational Neuroimmunology (J.W., C.G.), Department of Neurology, Jena University Hospital; Department of Neurology (M.W.H., C.T.), Hannover Medical School; and Department of Neurology (M.Senel), University Hospital, Ulm, Germany.

Article Synopsis
  • Eculizumab (ECU) has shown effectiveness in preventing attacks in patients with aquaporin-4 (AQP4)-IgG seropositive neuromyelitis optica spectrum disorders (NMOSDs) during a retrospective analysis in clinical settings between 2014 and 2022.
  • A total of 52 patients were studied, with 88% being attack-free during treatment, and the annualized attack rate significantly decreased from 1.0 to 0.
  • While common side effects included serious infections, five patients died from various complications, indicating a need for careful monitoring during long-term ECU therapy.
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Phase 2 Trial of Regorafenib in Recurrent/Metastatic Adenoid Cystic Carcinoma.

Clin Cancer Res

December 2024

Head and Neck Medical Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Article Synopsis
  • - The study tested regorafenib, a multi-targeted tyrosine kinase inhibitor, for treating patients with recurrent/metastatic adenoid cystic carcinoma (ACC), aiming to evaluate its effectiveness and identify biomarkers related to treatment response.
  • - Among 38 patients, no objective responses were observed, but 45% achieved 6-month progression-free survival (PFS), with longer PFS linked to specific immune-related tumor profiles and the presence of NOTCH1 or KDM6A alterations associated with poorer outcomes.
  • - The findings suggest that combining CDK4/6 inhibitors with VEGFR-TKIs might improve treatment efficacy, emphasizing the need to consider the role of the immune microenvironment in ACC treatment resistance.
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The mechanism by which small proteins fold, i.e., via intermediates or via a two-state mechanism, is a subject of intense investigation.

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