Understanding the reproductive ecology of Macrognathus aculeatus in wetland (Gajner beel) ecosystem: insights into eco-climatic influences in northwestern Bangladesh.

The lesser spiny eel, Macrognathus aculeatus (Bloch, 1786), holds substantial economic importance as a food fish in South Asia, due to its exceptional nutritional value. This study was conducted to investigate the reproductive ecology of M. aculeatus within the Gajner beel wetland ecosystem in northwestern Bangladesh, with a specific focus on size at sexual maturity, spawning season, and fecundity in relation to eco-climatic variables.

Visual Acuity Outcomes and Influencing Factors in a Cohort of UK Real-World Diabetic Macular Oedema Patients During the First Two Years of Anti-VEGF Treatment.

Background/objectives: The visual acuity (VA) outcomes after the first and second years of anti-vascular endothelial growth factor (anti-VEGF) treatment in patients with diabetic macular oedema (DMO) were evaluated, and the factors associated with treatment success were investigated.

Methods: Using Medisoft electronic medical records (UK), this retrospective cohort study analysed VA outcomes, changes, and determinants in DMO patients at year 1 and year 2 after initial anti-VEGF injection. Descriptive analysis examined baseline demographics and clinical characteristics, while regression models were used to assess associations between these factors and changes in VA.

Selective gold extraction from e-waste leachate via sulfur-redox mechanisms using sulfhydryl-functionalized MOFs.

Urban mining of precious metals from electronic waste (e-waste) offers a dual advantage by addressing solid waste management challenges and supplying high-value metals for diverse applications. However, traditional extraction methods generally suffer from poor selectivity and limited capacity in complex acidic leachate. Herein, we present a sulfhydryl-functionalized zirconium-based metal-organic framework (Zr-MSA-AA) as a recyclable and highly selective adsorbent for efficient gold recovery.

Exploring the Effect of Sampling Frequency on Real-World Mobility, Sedentary Behaviour, Physical Activity and Sleep Outcomes Measured with Wearable Devices in Rheumatoid Arthritis: Feasibility, Usability and Practical Considerations.

Modern treat-to-target management of rheumatoid arthritis (RA) involves titration of drug therapy to achieve remission, requiring close monitoring of disease activity through frequent clinical assessments. Accelerometry offers a novel method for continuous remote monitoring of RA activity by capturing fluctuations in mobility, sedentary behaviours, physical activity and sleep patterns over prolonged periods without the expense, inconvenience and environmental impact of extra hospital visits. We aimed to (a) assess the feasibility, usability and acceptability of wearable devices in patients with active RA; (b) investigate the multivariate relationships within the dataset; and (c) explore the robustness of accelerometry outcomes to downsampling to facilitate future prolonged monitoring.

Severe hypophosphatemia following idecabtagene vicleucel regardless of the severity of cytokine release syndrome.

Background Aims: Hypophosphatemia has been recently recognized adverse event in chimeric antigen receptor (CAR)-T cell therapy, complicating 70-75% of patients. Severe hypophosphatemia can cause cytokine release syndrome (CRS)-like symptoms, such as respiratory and cardiovascular dysfunction. Some reports have described the association between inorganic phosphate (iP) and CRS in patients treated with tisagenlecleucel (tisa-cel), lisocabtagene maraleucel (liso-cel), axicabtagene ciloleucel (axi-cel).

Schiff bases targeting an Sw-480 colorectal cell line: synthesis, characterization, ds-DNA binding and anticancer studies.

In present studies, six Schiff bases were prepared, characterized and evaluated for their anti-tumor activity against the colorectal cancer cell line SW-480. The test compounds were characterized by various physico-chemical techniques such as M. P.

Spatiotemporal control of translation in live zebrafish embryos via photoprotected mRNAs.

Translation of mRNA into protein is a fundamental process and tightly controlled during development. Several mechanisms acting on the mRNA level regulate when and where an mRNA is expressed. To explore the effects of conditional and transient gene expression in a developing organism, it is vital to experimentally enable abrogation and restoration of translation.

Determining the Rates of α-Tocopherol Movement in DPPC Vesicles Using Small Angle Neutron Scattering.

α-Tocopherol (αtoc, vitamin E) is an essential nutrient sufficiently acquired through a balanced diet. This fat-soluble vitamin is most known for its antioxidative properties, however, its fundamental mechanism of action in cellular membranes remains unknown. To this end, we use time-resolved small angle neutron scattering (TR-SANS) and a contrast matching scheme to determine intervesicular exchange (k) and intrabilayer flip-flop (k) rates of αtoc in 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) vesicles.

Utility of dual-chamber Electrogram-based pace mapping in a teenager with a focal atrial tachycardia, low inducibility, and indeterminate earliest excitation site.

A 17-year-old patient presented with frequent palpitations, where the tachycardia was not sustained and could not be induced, making it impossible to pinpoint the earliest activation site using the activation map. However, by utilizing a dual-chamber electrogram-based pace mapping technique, we successfully identified the origin and achieved effective treatment.

Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.

The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance and combined effects of these factors for humans is unclear.

Total functioning capacity scale in Huntington's disease: natural course over time.

Background And Objectives: The total functioning capacity (TFC) assessment has been integral to Huntington's disease (HD) research and clinical trials, measuring disease stage and progression. This study investigates the natural progression of function in HD, focusing on changes in TFC scores related to age and CAG-repeat length, and evaluates TFC's strengths and weaknesses in longitudinal studies.

Methods: Using Enroll-HD platform's clinical dataset version 5, including Registry-3, we analysed data from 21,079 participants, with 16,083 having an expanded CAG repeat.

Synthesis of zeolite from rice husk ash and kaolinite clay for the removal of methylene blue from aqueous solution.

Zeolite was successfully synthesized using a mixture of kaolinite clay (which served as the alumina source) and rice husk ash (silica source). The aim of this work was to synthesize highly efficient zelolite to remove methyle blue dye from aqueous solution. The synthesized adsorbent was characterised using Fourier Transform Infrared (FTIR) spectroscopy, powder x-ray diffraction (PXRD) analysis, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and pH at the point of zero charge (pHpzc).

Predicting Mortality in Patients Hospitalized With Acute Myocardial Infarction: From the National Cardiovascular Data Registry.

Background: In-hospital mortality risk prediction is an important tool for benchmarking quality and patient prognostication. Given changes in patient characteristics and treatments over time, a contemporary risk model for patients with acute myocardial infarction (MI) is needed.

Methods: Data from 313 825 acute MI hospitalizations between January 2019 and December 2020 for adults aged ≥18 years at 784 sites in the National Cardiovascular Data Registry Chest Pain-MI Registry were used to develop a risk-standardized model to predict in-hospital mortality.

Effect of Epstein-Barr Virus infection on gene regulation in immune cells of patients with Immune-Mediated Diseases.

It has been known that Epstein-Barr virus (EBV) can latently infect immune cells after the initial infection, and epidemiological studies have suggested its association with the onset of immune-mediated diseases (IMDs). However, the specific impact of EBV infection on IMDs pathology remains unclear. We quantified EBV load of B cell subsets (Naïve B cells, Unswitched memory B cells, Switched memory B cells, Double negative B cells, and Plasmablasts) in IMD patients as well as healthy control (HC) using bulk RNA sequencing data of 504 donors.

An Anthracene-Imidazoanthraquinone Conjugate Exhibiting Ratiometric Fluorescence Turn - on Behavior with CN and F Anions.

A new conjugate, 2-(4-(anthracen-9-yl) phenyl)-[1,2-d]imidazole-1H-anthraquninone (AQI) has been designed and synthesized as a molecular probe 4. The photophysical and electrochemical behavior of the probe in the absence and presence of different class of ions were examined in acetonitrile solution. The probe 4 with F and CN anions showed ratiometric fluorescence "turn - On" response due to variation in ICT processes.

Return to Sport After Treatment of Stable Osteochondritis Dissecans Lesions of the Knee in Adolescents: A Systematic Review.

Background: Treatment of stable osteochondritis dissecans (OCD) lesions of the knee in young patients poses the challenge of abstaining from competitive sports for months. Outcomes relevant to this patient population additionally include successful return to sport (RTS), return to the same level of sport, and the time needed to achieve both.

Purpose: To evaluate the adolescent population for RTS outcomes after treatment of stable OCD lesions of the knee and to compare RTS outcomes between patients treated nonoperatively and those who required surgery.

Early-Stage IM Treatment with the Host-Derived Immunostimulant CPDI-02 Increases Curative Protection of Healthy Outbred Mice Against Subcutaneous Infection with Community-Acquired Methicillin-Resistant USA300.

: Community-acquired methicillin-resistant (CA-MRSA) greatly complicates the treatment of skin and soft tissue infections (SSTI). It was previously found that subcutaneous (SQ) treatment with the mononuclear phagocyte (MP)-selective activator complements peptide-derived immunostimulant-02 (CPDI-02; formerly EP67) and increases prophylaxis of outbred CD-1 mice against SQ infection with CA-MRSA. Here, we determined if treatment with CPDI-02 also increases curative protection.

Solid- and Vapor-Phase Antibacterial Activities and Mechanisms of Essential Oils Against Fish Spoilage Bacteria.

Essential oils (EOs), regarded as secondary metabolites from plants, possess effective antibacterial properties. This study investigates the antibacterial efficacy of seven citrus EOs against six spoilage bacteria: , , , , , and . The antibacterial activity of these EOs was evaluated using solid- and vapor-phase applications.

How is Telehealth Used to Increase Access to Specialty Palliative Care? A Systematic Review.

Context: Specialty palliative care remains inaccessible for many with serious illness, especially in rural areas. Telehealth may be one solution.

Objectives: To describe how telehealth increases access to specialty palliative care, describe facilitators and barriers to its use, and summarize evidence of patient benefits.

Nanozymes and Their Potential Roles in the Origin of Life.

The origin of life has long been a central scientific challenge, with various hypotheses proposed. The chemical evolution, which supposes that inorganic molecules can transform into organic molecules and subsequent primitive cells, laid the foundation for modern theories. Inorganic minerals are believed to play crucial catalytic roles in the process.

Untreated plant waste of the Mediterranean region as bioadsorbent of persistent organic pollutants.

The excessive and/or improper use of plant protection products (PPPs) can generate alarming levels of residues in the environment, compromising both soil fertility and food safety. Various organic wastes released in large amounts by agro-industrial activity are currently studied and applied as bioadsorbents for water and soil decontamination. This study explored the capacity of untreated orange peel, olive stones and pistachio shells to adsorb the PPPs oxyfluorfen (OXY), metribuzin (MET) and imidacloprid (IMI), and the xenoestrogen bisphenol A (BPA) from water.

Diatom biosilica for liquid chromatography.

This work presents, for the first time, the preparation method and subsequent use of biosilica in column liquid chromatography in reverse-phase mode. Diatom biosilica consists of the siliceous exoskeletons (frustules) of unicellular algae. Controlled cultivation of Pseudostaurosira trainorii diatoms resulted in frustules with an average diameter of approximately 4 µm, sidewall thickness of 1 µm, and a bottom thickness of 110-150 nm.