Does dose matter? Parental attendance in a preventive intervention for anxious and sad children.

Background: International studies show increasing prevalence of anxiety and depression among children. Parents are vital for children in all aspects of life, also in supporting their offspring in promoting better mental health, life skills and reducing emotional difficulties. Therefore, involving parents in interventions aimed at preventing development of anxiety and depression is natural.

Mortality and cancer incidence in the UK glass reinforced plastics manufacturing industry: a cohort study.

Objectives: According to the International Agency for Research on Cancer, styrene is probably carcinogenic for lymphohaematopoietic neoplasms, with insufficient evidence for other cancer sites. We compared mortality and cancer incidence (for the first time) in a UK cohort occupationally exposed to high levels of styrene to that of the general population of England and Wales.

Methods: The follow-up for mortality ran from 1969 to 2022, while the follow-up for cancer incidence ran from 1971 to 2020.

Geographical differences in thrombolysis treatment for acute ischaemic stroke.

Background: Administering intravenous thrombolysis (IVT) as soon as possible after symptom onset impacts on the functional outcome for patients with acute ischaemic stroke. The study aimed to assess whether the distance from hospital impacts on the access to IVT for acute ischaemic stroke at the University Hospital of North Norway in Tromsø (UNN Tromsø).

Material And Method: This prospective quality study included 231 patients admitted with acute ischaemic stroke to UNN in the period 1 January 2019-31 December 2019.

The history of Jervell and Lange-Nielsen syndrome.

Background: First-time documentation of rare diseases is normally in the form of case reports. These are typically based on unexpected observations by vigilant clinicians and lead to further research on prevalence and aetiology. One of the best-known Norwegian examples is Jervell and Lange-Nielsen syndrome.

EXPRESS: COGNITIVE AND AFFECTIVE PROCESSES IN CHILDREN'S THIRD-PARTY PUNISHMENT.

This study investigated how children's punishment affective states change over time, as well as when children begin to prioritise intentions over outcomes in their punishment decisions. Whereas most prior research sampled children from Anglo-America or Northwestern Europe, we tested 5- to 11-year-old children from Colombia and Spain (N = 123). We focused on punishment behaviour in response to ostensibly real moral transgressions, rather than punishment recommendations for hypothetical moral transgressions.

Proton Occupancies in Histidine Side Chains of Carbonic Anhydrase II by Neutron Crystallography and NMR - Differences, Similarities and Opportunities.

Histidine is a key amino-acid residues in proteins that can exist in three different protonation states: two different neutral tautomeric forms and a protonated, positively charged one. It can act as both donor and acceptor of hydrogen bonds, coordinate metal ions, and engage in acid/base catalysis. Human Carbonic Anhydrase II (HCA II) is a pivotal enzyme catalyzing the reversible hydration of carbon dioxide.

The Water Framework Directive's protection of groundwater-dependent terrestrial ecosystems.

The Water Framework Directive protects groundwater-dependent terrestrial ecosystems, but its concepts and definitions remain unclear. This paper aims to clarify the margin of discretion for the Member States, by applying a cross-disciplinary legal and biological analysis. We conclude that description of the protected ecosystems must include at least key components and processes and be based on a number of well-known groundwater-dependent habitats, but not restricted to habitats fed entirely by groundwater.

Outcomes of Gallbladder Drainage Techniques in Acute Cholecystitis: Percutaneous Versus Endoscopic Methods.

Acute cholecystitis, often caused by gallstones obstructing the cystic duct, is a potentially life-threatening condition that requires timely intervention. High-risk patients, particularly those with significant comorbidities, may not be suitable candidates for laparoscopic cholecystectomy, necessitating alternative drainage techniques such as percutaneous cholecystostomy (PC) and endoscopic gallbladder drainage (EGD). This systematic review aims to compare the efficacy, safety, and outcomes of PC and EGD in managing acute cholecystitis in high-risk surgical patients.

-related disorder in 87 adults: Natural history and self-sustainability.

Purpose: is one of the most frequently mutated genes in intellectual disability cohorts. Thus, far few adult-aged patients with -related disorder have been described, which limits our understanding of the disease's natural history and our ability to counsel patients and their families.

Methods: Data on patients aged 18+ years with -related disorder were collected through an online questionnaire completed by clinicians and parents.

Sex-mediated effects of transglutaminase 2 inhibition on endothelial function in human resistance arteries from diabetic and non-diabetic patients.

Transglutaminase 2 (TG2) is an enzyme with multiple conformations. In its open conformation, TG2 exhibits transamidase activity linked to fibrosis, arterial remodeling, and endothelial dysfunction, a process enhanced by high glucose in endothelial cells. However, the closed conformation of TG2 contributes to transmembrane signaling and nitric oxide (NO)-dependent vasorelaxation.

Sociodemographic and clinical predictors of quality-of-life outcome in children and young people with primary brain tumour in Karachi, Pakistan: a prospective cohort study.

Background: Children and young people (CYP) with primary brain tumour (PBT) are at high risk for developing late effects, potentially affecting long-term quality of life (QoL). In low-income and middle-income countries, QoL has not been studied in depth in CYP. In the present study, CYP treated for PBTs in Pakistan were evaluated regarding (A) mean change in QoL scores pretreatment and 12 months post-treatment and (B) predictors of change in QoL scores 12 months post-treatment.

The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes.

A dense glycocalyx, composed of the megaDalton-sized membrane mucin MUC17, coats the microvilli in the apical brush border of transporting intestinal epithelial cells, called enterocytes. The formation of the MUC17-based glycocalyx in the mouse small intestine occurs at the critical suckling-weaning transition. The glycocalyx extends 1 µm into the intestinal lumen and prevents the gut bacteria from directly attaching to the enterocytes.

[Retrograde cricopharyngeal dysfunction (inability to belch) - a »new« diagnosis that deserves attention].

The belching reflex involves transient lower oesophageal sphincter relaxation and relaxation of the cricopharyngeus (CP). In some individuals, the  latter stage fails,leading to return of gas to the stomach. This pattern is then repeated, which is accompanied by chest pain and loud, gurgling noises.

Combination of phenylsilsesquioxane and acetate ligands as an approach to a record high nuclear Cu13Na2-cage. Synthesis, unique structure, and catalytic activity.

Self-assembly synthesis of mixed-ligand (silsesquioxane/acetate) complex allows to isolate record high nuclear copper(II) Cu13-cage (1). In the presence of two additional sodium ions, a unique molecular architecture, with triple combination of ligands (cyclic and acyclic silsesquioxanes as well as acetates), has been formed. The structure was established by single-crystal X-ray diffraction based on the use of synchrotron radiation.

[Christmas article: Maximum bladder capacity at an anesthesiology department’s Christmas party].

Introduction: Christmas parties, a longstanding Danish tradition, became festive occasions in the 1960s. This study examines if healthcare professionals, especially doctors and nurses, have larger bladder capacities than the general population, as they often delay restroom breaks.

Methods: At the North Zealand University Hospital Department of Anesthesiology's 2023 Christmas party, participants delayed urination until a strong urge occurred.

[Christmas article: Can chili improve the performance of Santa Claus and goblins? A randomized study].

Introduction: Many children expect a visit from Santa Claus, preferably on Christmas Eve and the teasing goblins are active teasing throughout the month of December. Therefore, Santa Claus and goblins must be in good shape for the activities of December. Rice pudding, Christmas pancakes, and other goodies are consumed in large quantities to help both the size of Santa Claus as well as the activity level of the Christmas teasing.

A Comparative Study of Aortic Valve Neocuspidization Techniques: Formula vs. Template Methods of Neocusp Formation.

Introduction: The template method (TM), pioneered by Ozaki for aortic valve neocuspidization (AVNeo), has been widely adopted for aortic valve replacement, though it requires specialized instruments. This study introduces a novel formula method (FM), which uses the diameter of the aortic valve fibrous ring (AV-D) to determine the dimensions of the neocusps to be trimmed from autologous without the need for templates, potentially reducing costs and complexity. We aimed to compare the clinical outcomes of the FM with the established TM in patients undergoing AVNeo.

The amplification of alpha-synuclein amyloid fibrils is suppressed under fully quiescent conditions.

Seed amplification assays (SAAs) are a promising avenue for the early diagnosis of neurodegenerative diseases. However, when amplifying fibrils from patient-derived samples in multiwell plates, it is currently highly challenging to accurately quantify the aggregates. It is therefore desirable to transfer such assays into a digital format in microemulsion droplets to enable direct quantification of aggregate numbers.

Integrative Molecular Dynamics Simulations Untangle Cross-Linking Data to Unveil Mitochondrial Protein Distributions.

Cross-linking mass spectrometry (XL-MS) enables the mapping of protein-protein interactions on the cellular level. When applied to all compartments of mitochondria, the sheer number of cross-links and connections can be overwhelming, rendering simple cluster analyses convoluted and uninformative. To address this limitation, we integrate the XL-MS data, 3D electron microscopy data, and localization annotations with a supra coarse-grained molecular dynamics simulation to sort all data, making clusters more accessible and interpretable.