Nipocalimab in Early-Onset Severe Hemolytic Disease of the Fetus and Newborn.

Background: In early-onset severe hemolytic disease of the fetus and newborn (HDFN), transplacental transfer of maternal antierythrocyte IgG alloantibodies causes fetal anemia that leads to the use of high-risk intrauterine transfusions in order to avoid fetal hydrops and fetal death. Nipocalimab, an anti-neonatal Fc receptor blocker, inhibits transplacental IgG transfer and lowers maternal IgG levels.

Methods: In an international, open-label, single-group, phase 2 study, we assessed treatment with intravenous nipocalimab (30 or 45 mg per kilogram of body weight per week) administered from 14 to 35 weeks' gestation in participants with pregnancies at high risk for recurrent early-onset severe HDFN.

Ensuring quality in 17OHP mass spectrometry measurement: an international study assessing isomeric steroid interference.

Objectives: Interference from isomeric steroids is a potential cause of disparity between mass spectrometry-based 17-hydroxyprogesterone (17OHP) results. We aimed to assess the proficiency of mass spectrometry laboratories to report 17OHP in the presence of known isomeric steroids.

Methods: A series of five samples were prepared using a previously demonstrated commutable approach.

Neural processing of bottom-up perception of biological motion under attentional load.

Considering its importance for one's survival and social significance, biological motion (BM) perception is assumed to occur automatically. Previous behavioral results showed that task-irrelevant BM in the periphery interfered with task performance at the fovea. Under selective attention, BM perception is supported by a network of regions including the occipito-temporal (OTC), parietal, and premotor cortices.

A Large Video Set of Natural Human Actions for Visual and Cognitive Neuroscience Studies and Its Validation with fMRI.

The investigation of the perception of others' actions and underlying neural mechanisms has been hampered by the lack of a comprehensive stimulus set covering the human behavioral repertoire. To fill this void, we present a video set showing 100 human actions recorded in natural settings, covering the human repertoire except for emotion-driven (e.g.

Racism against Totonaco women in Veracruz: Intercultural competences for health professionals are necessary.

Racism is a neglected but relevant cause of health disparities within multi-ethnic societies. Different types of racism and other expressions of discrimination must be recognized, critically analyzed, and actively reverted. This paper is based on anthropological fieldwork conducted in three medical facilities in the indigenous region Sierra de Totonacapan in the highlands of Veracruz in Mexico and analyzes maternal health and identifies levels of racism as perceived by female indigenous patients.

[Weighting of Orthopaedics & Trauma Surgery in the Medical State Examination - Comparison of the Written Examination with the National Catalogue of Learning Objectives in Surgery].

Background: The national competence-based catalogue of learning-goals in surgery (NKLC) defines competence levels for each of its 230 goals, including "competence level in 1: factual knowledge" up to "competence level 3: independent action". Aside from the cumulative examinations influencing the learning behaviour of students, those teaching targets do not affect the second state examination. This study analyses the extent to which the questions of the German second medical licensing examination compiled by the IMPP (central German institute for medical and pharmaceutical examinations) are congruent with the trauma-surgical and orthopaedic learning goals in the NKLC, in which this thematic focus is emphasised.

[The Medical Examination - Between Desire and Reality - Analysis of Consensus Between the Second Part of the Medical Licensing Exam (IMPP) and the National Catalogue of Expertise-based Learning Goals in Surgery (NKLC)].

The working party of the German Society for Surgery (DGCH) on undergraduate surgical education has developed a national expertise-based catalogue of learning goals in surgery (NKLC). This study analyses the extent to which the questions of the German second medical licensing examination compiled by the IMPP are congruent with the NKLC and which thematic focus is emphasised. Firstly, a guideline and evaluation sheet were developed in order to achieve documentation of the individual examination questions of the second licensing examination with respect to the learning goals of the NKLC.

[Teaching medical students informed consent].

Background And Objectives: Teaching competencies in communication are important for medical education, but implementation in the surgical curriculum is still deficient. Communication during informed consent is one main issue. The aim of the study was to implement a reproducible teaching module for informed consent, which closely represents reality.

[Complications and prognosis of cervical sialoceles in the dog using the lateral surgical approach].

Objective: Evaluation of intra- and postoperative complications and prognosis of cervical sialoceles in the dog when using the lateral surgical approach for extirpation of the mandibular and sublingual salivary glands.

Material And Methods: Medical records of 16 dogs with 19 sialoceles were evaluated retrospectively. Long-term follow-up was evaluated by telephone questionnaire to the owners or the referring veterinarian.

Follow up of complete subtalar release for clubfoot--Evolution of different scores.

Background: Even today there are still some cases of clubfoot that require a more extensive form of treatment. Thus, it is still essential to ascertain the development of the clubfoot after extensive release operations.

Method: 70 children presenting 99 cases of primary clubfoot (age 8 months-10 years) were followed up after 4.

[Treatment of epicondylitis - a current review].

Lateral epicondylitis or tennis elbow is a common injury, which affects not only people who play tennis but occurs with many different activities. It reflects overuse of the extensor muscles of the forearm. There are some other pathologies which have to be separated from epicondylitis.

[Experiences with a theloresectoscope compared with conventional teat endoscopy in diagnosis and therapy of covered teat lesions].

In 30 dairy-cows, suffering from a covered teat lesion near the papillar duct and, as a result, from milk flow hindrance, two different methods of minimal invasive endoscopy for diagnosis and therapy were performed. In 15 patients (group I) the endoscope was inserted through the papillar duct and additionally through an artificial approach in the teat wall. Avulsions of mucosa could be visualized and resected with special instruments.

[Endoscopic assessment of the mucosal tolerance of a new papillary duct bougie compared with conventional mammary cannulas].

In this study on healthy, milking cows three per group a temporary drying off for five days, using two types of conventional teat bougies (group A, B), one type of a teat canula (group C) and one type of a novel wax-bougie, developed by Dr. Th. Geishauser (group D) was performed.

[Teat endoscopy as a diagnostic procedure in the goat].

Teat endoscopy as a diagnostic procedure in the goat is described in a clinical case of a proliferation in the wall of the teat cisterna. Modifications in proceeding and equipment compared to the common use of endoscopy in the teat of cattle are shown and the additional amount of information in comparison to palpation, sounding and sonography is evaluated.

[Use of visual methods (sonography/endoscopy) for the diagnosis of a webbed teat in cattle. A case report].

The use of visual methods (sonography/endoscopy) for the diagnosis of a webbed teat in a cow with particular consideration of differentiation from a teat fistula is reported. The sonographical and endoscopical investigation of a webbed teat is evaluated concerning its gain of information in comparison to classical diagnostic procedures.

[The topography of the cecum and proximal loop of the colon in cattle with cecal dilatation].

The topography of the cecum and the proximal loop of the colon was studied in 32 cattle of different german breeds, female gender and different age (5.2 +/- 2.0 years), which were surgically treated for cecal dilatation in the Medical and Forensic Veterinary Clinic II of the Justus-Liebig-University in Giessen.

[Fat/protein ratio in the milk of cattle herds in which displacement of the abomasum occurs].

The fat:protein ratio of the milk was calculated for 27 herds in Hessia breeding German Black Pied Cattle, in which displacement of the abomasum occurred (case herds) and in 27 similar herds, in which displacement of the abomasum did not occur (control herds). This was measured for the year preceding the displacements as well as for the month in which displacement occurred. Control herds were selected which had the same number of lactating cattle and the same milk yield (lbs).

[Detection of distemper virus N protein RNA in the brain of dogs with spontaneous distemper encephalitis using a digoxigenin-labeled, double-stranded DNA probe for in situ hybridization].

A digoxigenin-labelled dsDNA-probe of 287 basepairs length complementary to the nucleoprotein-gene of canine distemper virus (CDV) was generated by the polymerase-chain-reaction. The dsDNA-probe hybridized specifically with base sequences of 8 different CDV strains, whereas no hybridization was observed with a porpoise and a canine parainfluenza virus and only a weak signal was obtained with measles virus. In formalin-fixed, paraffin-embedded brain sections of 35 immunohistologically CDV antigen positive dogs with spontaneous distemper encephalitis CDV-RNA could be detected in 25 cases by in situ hybridization.

[The use of nonpathogenic leptospira as diagnostic antigens for the diagnosis of leptospira infections in cattle].

The seroprevalence of leptospira antibodies was determined in 4377 bovine sera by microagglutination assay using 11 Leptospira interrogans serovars. In 10% (439 samples) of the sera, a positive reaction was detected. These included 275 sera (62.

[Bridging tension band fixation in the reconstruction of ruptured amphiarthrosis of the pelvic girdle].

Two different surgical techniques to treat rupture of the symphysis or the sacroiliac joint, which were introduced at the beginning of the seventies and were modified later, are presented in regards to their methodology and their results. In a lot of cases after surgery they enable a normal spring-suspension of the pelvis.

[The ultrastructure of the nucleus of the solitary tract of the sheep and goat].

The sensory nucleus of the IXth and Xth cranial nerve in sheep and goat takes a position in the middle of the elongated medulla forming a bilateral symmetric cell column. Neighbouring the canalis centralis dorsolaterally the caudal segments of both nuclei are connected in the raphe region by a subnucleus commissuralis. The solitary tract defines the nucleus in its lateral extension.

Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the "pexin" family and a model for their evolution.

The S-protein/vitronectin gene was isolated from a human genomic DNA library, and its sequence of about 5.3 kilobases including the adjacent 5' and 3' flanking regions was established. Alignment of the genomic DNA nucleotide sequence and the cDNA sequence indicated that the gene consisted of eight exons and seven introns.