15,347 results match your criteria: "Justus-Liebig- University[Affiliation]"
JCI Insight
November 2024
Department of Cardiology, Heart Center, Faculty of Medicine and University Hospital Cologne.
Chronic activation of the adaptive immune system is a hallmark of atherosclerosis. As PI3Kδ is a key regulator of T and B cell differentiation and function, we hypothesized that alleviation of adaptive immunity by PI3Kδ inactivation may represent an attractive strategy counteracting atherogenesis. As expected, lack of hematopoietic PI3Kδ in atherosclerosis-prone Ldlr-/- mice resulted in lowered T and B cell numbers, CD4+ effector T cells, Th1 response, and immunoglobulin levels.
View Article and Find Full Text PDFMicrobiol Spectr
November 2024
Medical Faculty, Institute of Biochemistry and Pathobiochemistry-Microbial Biochemistry, Ruhr University Bochum, Bochum, Germany.
While highly effective at killing Gram-positive bacteria, auranofin lacks significant activity against Gram-negative species for reasons that largely remain unclear. Here, we aimed to elucidate the molecular mechanisms underlying the low susceptibility of the Gram-negative model organism to auranofin when compared to the Gram-positive model organism . The proteome response of exposed to auranofin suggests a combination of inactivation of thiol-containing enzymes and the induction of systemic oxidative stress.
View Article and Find Full Text PDFCardiol Young
October 2024
Department of Pediatric Cardiology, Intensive Care Medicine and Congenital Heart Disease, Justus Liebig University, Gießen, HE, 35390, Germany.
Nat Commun
October 2024
Institute of Virology, University of Marburg, Marburg, Germany.
Infection
October 2024
Department of Medicine V - Internal Medicine, Infectious Diseases & Infection Control, Justus- Liebig-University, Giessen, Germany.
J Appl Anim Welf Sci
October 2024
Working Group for Applied Ethology and Animal Behaviour Therapy, Department of Veterinary Clinical Sciences, Justus Liebig University Giessen, Giessen, Germany.
BMC Psychiatry
October 2024
Department of Clinical Psychology, Philipps University of Marburg, Marburg, Germany.
Toxicon
November 2024
Institute for Insect Biotechnology, Justus Liebig University of Giessen, Heinrich-Buff Ring 26-32, 35392, Giessen, Germany; Animal Venomics Lab, Fraunhofer Institute for Molecular Biology and Applied Ecology, Ohlebergsweg 12, 35392, Giessen, Germany; LOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325, Frankfurt, Germany.
J Environ Manage
November 2024
Co-Innovation Center for Sustainable Forestry in Southern China, Jiangsu Province Key Laboratory of Soil and Water Conservation and Ecological Restoration, Nanjing Forestry University, 159 Longpan Road, Nanjing, Jiangsu, 210037, China. Electronic address:
Peat is typically used as a carrier for microbial inoculants; however, due to its non-renewable nature alternatives need to be identified as reliable and renewable carriers for mineral-solubilizing inoculants. In pot experiments, solid microbial inoculants were comprised of peat (P), biochar (BC), and spent mushroom substrates (SMS) using Medicago sativa L. as experimental materials, and the purpose of this study is to assess the effect of solid microbial inoculants on soil multifunctionality and plant growth.
View Article and Find Full Text PDFNPJ Microgravity
October 2024
Center for Vision Research, York University, Toronto, ON, Canada.
Altering posture relative to the direction of gravity, or exposure to microgravity has been shown to affect many aspects of perception, including size perception. Our aims in this study were to investigate whether changes in posture and long-term exposure to microgravity bias the visual perception of object height and to test whether any such biases are accompanied by changes in precision. We also explored the possibility of sex/gender differences.
View Article and Find Full Text PDFMol Cell
October 2024
Institute of Biochemistry, FB08, Justus Liebig University, 35392 Giessen, Germany; Cardio-Pulmonary Institute (CPI), EXC 2026, 35392 Giessen, Germany. Electronic address:
PLoS Negl Trop Dis
October 2024
Clinical Research Department, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Mol Ecol Resour
January 2025
Aquatic Ecosystem Research, University of Duisburg Essen, Essen, Germany.
Mitigating ongoing losses of insects and their key functions (e.g. pollination) requires tracking large-scale and long-term community changes.
View Article and Find Full Text PDFMol Plant Pathol
October 2024
Institute of Phytopathology, Research Centre for BioSystems, Land Use and Nutrition, Justus Liebig University Giessen, Giessen, Germany.
Fusarium fungi are a pervasive threat to global agricultural productivity. They cause a spectrum of plant diseases that result in significant yield losses and threaten food safety by producing mycotoxins that are harmful to human and animal health. In recent years, the exploitation of the RNA interference (RNAi) mechanism has emerged as a promising avenue for the control of Fusarium-induced diseases, providing both a mechanistic understanding of Fusarium gene function and a potential strategy for environmentally sustainable disease management.
View Article and Find Full Text PDFMethods Mol Biol
October 2024
Institute for Microbiology and Molecular Biology, Justus-Liebig University Giessen, Giessen, Germany.
Sci Rep
October 2024
Institute for Microbiology and Molecular Biology, Justus Liebig University Giessen, 35392, Giessen, Germany.
Bacterial dormancy is marked by reduced cellular activity and the suspension of growth. It represents a valuable strategy to survive stressful conditions, as exemplified by the long-term tolerance towards antibiotics that is attributable to a fraction of dormant cells, so-called persisters. Here, we investigate the membrane toxin TisB (29 amino acids) from the chromosomal toxin-antitoxin system tisB/istR-1 in Escherichia coli.
View Article and Find Full Text PDFSci Rep
October 2024
Institute of Neuropathology, Justus-Liebig University, Giessen, Germany.
To gain a deeper understanding of skeletal muscle function in younger age and aging in elderly, identification of molecular signatures regulating these functions under physiological conditions is needed. Although molecular studies of healthy muscle have been conducted on adults and older subjects, there is a lack of research on infant muscle in terms of combined morphological, transcriptomic and proteomic profiles. To address this gap of knowledge, we performed RNA sequencing (RNA-seq), tandem mass spectrometry (LC-MS/MS), morphometric analysis and assays for mitochondrial maintenance in skeletal muscle biopsies from both, infants aged 4-28 months and adults aged 19-65 years.
View Article and Find Full Text PDFBone Jt Open
October 2024
Kardinal Schwarzenberg Clinic, Schwarzach im Pongau, Austria.
Can Vet J
October 2024
Veterinary Clinic for Reproductive Medicine and Neonatology, Justus-Liebig-University Giessen, Frankfurter Str. 106, 35392 Giessen, Germany (Stahl, Krohn, Wehrend); Clinic for Ruminants and Herd Health Management, Justus-Liebig-University Giessen, Frankfurter Str. 104, 35392 Giessen, Germany (Stahl); Unit for Biomathematics and Data Processing, Justus-Liebig-University Giessen, Frankfurter Str. 95, 35392 Giessen, Germany (Büttner).
Background: Selenium supply plays a major role in calf rearing, as a deficiency can lead to health problems, economic loss, and even death. Therefore, postnatal selenium injections are often administered as a preventive measure.
Objective: In this study, we examined the serum selenium concentrations of healthy and sick calves within the first days of life.
In everyday tasks, the choices we make incorporate complex trade-offs between conflicting factors that affect how we will achieve our goals. Previous experimental research has used dual-target visual search to determine how people flexibly adjust their behaviour and make choices that optimise their decisions. In this experiment, we leveraged a visual search task that incorporates complex trade-offs, and electroencephalography (EEG), to understand how neural mechanisms of selective attention contribute to choice behaviour in these tasks.
View Article and Find Full Text PDFInfection
October 2024
Department of Anaesthesiology, LMU Hospital, LMU Munich, 81377, Munich, Germany.
Background: Compared to intensive care unit patients with SARS-CoV-2 negative acute respiratory tract infections, patients with SARS-CoV-2 are supposed to develop more frequently and more severely neurologic sequelae. Delirium and subsequent neurocognitive deficits (NCD) have implications for patients' morbidity and mortality. However, the extent of brain injury during acute COVID-19 and subsequent NCD still remain largely unexplored.
View Article and Find Full Text PDFClin Res Cardiol
December 2024
University Heart Centre Regensburg, Department of Internal Medicine II, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Nat Commun
September 2024
Department of Evolutionary Genetics, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.
Sci Total Environ
December 2024
Centre for International Development and Environmental Research, Justus Liebig University Giessen, Senckenbergstr. 3, 35390 Giessen, Germany; Institute for Landscape Ecology and Resources Management (ILR), Justus Liebig University, Heinrich-Buff-Ring 26, 35392 Giessen, Germany.
The nutrient status of rivers and streams is less researched in sub-Saharan Africa than in many other inhabited regions of the world. Given the expected population growth, intensification of agriculture, increased pressure on natural ecosystems and projected climate change in sub-Saharan Africa, it is crucial to quantify and understand drivers behind spatiotemporal patterns of nitrogen concentrations and loads in rivers and streams. Such knowledge can support sustainable management of water resources with the goal to provide clean water, create and maintain healthy ecosystems and prevent excessive pollution of water resources with nitrogen compounds, as is found in large parts of North America, Europe and Asia.
View Article and Find Full Text PDFJ Clin Oncol
December 2024
Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf, University of Cologne, Medical Faculty and University Hospital Cologne, Cologne, Germany.