Circulation of West Nile virus and Usutu virus in birds in Germany, 2021 and 2022.

Background: Usutu virus (USUV) and West Nile virus (WNV) are zoonotic arthropod-borne orthoflaviviruses. The enzootic transmission cycles of both include mosquitoes as vectors and birds as amplifying hosts. For more than 10 years, these viruses have been monitored in birds in Germany by a multidisciplinary network.

Underestimation of personal carbon footprint inequality in four diverse countries.

Extensive research highlights global and within-country inequality in personal carbon footprints. However, the extent to which people are aware of these inequalities remains unclear. Here we use an online survey distributed across four diverse countries: Denmark, India, Nigeria and the USA, to show widespread underestimation of carbon footprint inequality, irrespective of participants' country and income segment.

Glycolipidomics of Liver Flukes and Host Tissues during Fascioliasis: Insights from Mass Spectrometry Imaging.

Fascioliasis, a zoonotic disease caused by liver flukes of the genus , poses significant health threats to both humans and livestock. While some infections remain asymptomatic, others can lead to fatal outcomes, particularly during the acute phase characterized by the migration of immature parasites causing severe liver damage. Through the combination of data acquired via high-spatial-resolution atmospheric-pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging (AP-SMALDI MSI) and nanohydrophilic interaction chromatography tandem mass spectrometry, we investigated glycosphingolipids (GSLs) in both adult and immature parasite stages as well as the host liver and bile duct to unravel the intricacies of the host-pathogen interplay and associated pathology.

Predicting analog intrusions from neural correlates of immediate and lasting effects of cognitive reappraisal.

Emotional dysregulation is considered as an etiologically relevant factor for posttraumatic stress disorder. The relevance of immediate and lasting effects of cognitive reappraisal, a prominent emotion regulation strategy, and its habitual use for the development of posttraumatic stress symptoms in response to an experimental trauma are therefore investigated in our study. Eighty-five healthy women participated in a functional magnetic resonance imaging study, which included an emotion regulation paradigm prior to the conduction of the trauma film paradigm, which was used to assess the development of analog intrusions.

Association of daily physical activity with pulmonary artery pressure in HFpEF and HFmrEF NYHA class III patients: a pilot trial-feasibility and first results.

Introduction: Supervised physical exercise has been shown to benefit patients with heart failure with preserved/mildly reduced ejection fraction (HFpEF/HfmrEF) by improving symptoms and diastolic function. This study aimed to investigate the correlation between unsupervised daily physical activity and changes in daily pulmonary artery pressure (PAP) in patients with stable NYHA class III heart failure (HF) and left ventricular ejection fraction (LVEF) of 45% or higher.

Methods: Daily physical activity was monitored over a 3-month period using a Holter-ECG with an accelerometer that calculated an activity-associated, heart rate-derived metabolic equivalent of task (MET) score.

Real-world characteristics and treatment of cardiac transthyretin amyloidosis: A multicentre, observational study.

Aims: Data on the clinical profiles of patients with transthyretin amyloidosis cardiomyopathy (ATTR-CM) in the post-approval era of tafamidis 61 mg are lacking. Study aims were characterization of contemporary ATTR-CM patients, analysis of potential eligibility for the 'Transthyretin Amyloidosis Cardiomyopathy Clinical Trial' (ATTR-ACT) and identification of factors associated with the decision on tafamidis 61 mg treatment.

Methods And Results: This retrospective study analysed ATTR-CM patients seen at eight University Hospitals in the first year after approval of tafamidis 61 mg for ATTR-CM in Germany (April 2020 to March 2021).

Research note: Effect of a biotechnologically produced Pleurotus sapidus mycelium on expression of genes involved in protein synthesis and degradation in breast muscle of broilers.

Recently, feeding a fungal mycelium from Pleurotus sapidus was found to reduce relative breast muscle weight of broilers. The present study tested the hypothesis that dietary inclusion of P. sapidus mycelium modulates the expression of genes involved in protein anabolic and protein catabolic pathways in breast muscle of broilers.

Copper excess transcriptional responses in roots of grapevine (Vitis sp.) rootstocks.

Copper (Cu) is an essential element for plants, participating in photosynthesis, oxidative metabolism and cell wall synthesis. However, excessive Cu may become toxic, as Cu participates in Fenton chemistry and cause oxidative stress. Grapevine (Vitis sp.

Point-of-care ultrasound training in nephrology: a position statement by the International Alliance for POCUS in Nephrology.

Point-of-care ultrasonography (POCUS) has rapidly evolved from a niche technology to an indispensable tool across medical specialties, including nephrology. This evolution is driven by advancements in technology and the visionary efforts of clinicians in emergency medicine and beyond. Recognizing its potential, medical schools are increasingly integrating POCUS into training curricula, emphasizing its role in enhancing diagnostic accuracy and patient care.

Novel antimicrobial coating for hernia meshes.

Purpose: Antibiotic coating for several medical devices has been carried out; however, there are only few studies about coating hernia meshes with antimicrobial substances. In this study we checked the capacity of different commercially available hernia meshes to act as drug carrier.

Methods: The meshes were coated with gentamicin palmitate, chlorhexidine palmitic acid and chlorhexidine palmitate.

Downstream effects of the pandemic? Spatiotemporal trends of quaternary ammonium compounds in suspended particulate matter of German rivers.

During the SARS-CoV-2 pandemic, the preventive use of antimicrobials such as quaternary ammonium compounds (QACs) surged worldwide. As cationic and surface-active biocides, QACs are only partly removed during wastewater treatment and may cause adverse ecological effects in the downstream environment. To understand the environmental consequences of increased disinfectant use during the pandemic, we investigated spatiotemporal QAC concentration trends in the suspended particulate matter (SPM) of three diverse German rivers.

Cement Viscosity and Application Time Lead to Significant Changes in Cement Penetration and Contact Surface Area.

Background: Application time and viscosity are factors that can significantly affect the properties of bone cement and implant fixation. The aim of this study was to investigate the influence of different application times of 2 different cements on mechanical parameters, cement interdigitation, and cement distribution.

Methods: P.

17α-Ethynylestradiol alters testicular epigenetic profiles and histone-to-protamine exchange in mice.

Spermatogenesis starts with the onset of puberty within the seminiferous epithelium of the testes. It is a complex process under intricate control of the endocrine system. Physiological regulations by steroid hormones in general and by estrogens in particular are due to their chemical nature prone to be disrupted by exogenous factors acting as endocrine disruptors (EDs).

Advocating individual-based profiles of elite athletes to capture the multifactorial nature of elite sports performance.

Elite athletes are high-performance outliers within their specific sports. Even though science seeks to understand the nature of expertise and elite performance, much knowledge remains compartmentalized within subdisciplines. Despite this multidimensionality being acknowledged, an interdisciplinary approach to understanding elite athletes is still rare.

Robotic surgery of the urothelial carcinoma of the upper urinary tract single surgeon initial experience, 66 consecutive cases.

Purpose: Robotic surgery is increasingly utilized in the treatment of urothelial carcinoma of the upper urinary tract (UTUC). This study investigates the advantages and burden of robot-assisted surgical treatment of the urothelial carcinoma of the upper urinary tract in a referral urological department, along with their functional and oncological results.

Methods: The study included 66 prospectively enrolled patients who were surgically treated by a single, robotically specialized surgeon between July 2019 and December 2023.

Host dependent specialized metabolism of nitrogen export in actinorhizal nodules induced by Frankia cluster-2.

Frankia cluster-2 strains are diazotrophs that engage in root nodule symbiosis with actinorhizal plants of the Cucurbitales and the Rosales. Previous studies have shown that an assimilated nitrogen source, presumably arginine, is exported to the host in nodules of Datisca glomerata (Cucurbitales), while a different metabolite is exported in the nodules of Ceanothus thyrsiflorus (Rosales). To investigate if an assimilated nitrogen form is commonly exported to the host by cluster-2 strains, and which metabolite would be exported in Ceanothus, we analysed gene expression levels, metabolite profiles, and enzyme activities in nodules.

Hyrtios sp.-associated Cladosporium sp. UR3 as a potential source of antiproliferative metabolites.

Background: Sponge-associated microorganisms are promising resources for the production of bioactive compounds with cytotoxic potential. The main goal of our study is to isolate the fungal endophytes from the Red Sea sponge Hyrtios sp. followed by investigating their cytotoxicity against number of cell lines.

Identification of red flags for IgG4-related disease: an international European Reference Network for Rare Connective Tissue Diseases framework.

IgG4-related disease is a rare fibroinflammatory condition. Prompt recognition is fundamental to initiate treatment and to prevent organ damage. Diagnostic and classification criteria are primarily intended for use by clinicians with established expertise in IgG4-related disease.

Association among raised intraventricular pressure, clinical signs, and magnetic resonance imaging findings in dogs with congenital internal hydrocephalus.

Background: Dogs with internal hydrocephalus do not necessarily have high intraventricular pressure (IVP).

Hypothesis/objectives: Not all reported MRI findings indicate high IVP and some clinical signs might be associated with elevated IVP and syringomyelia.

Animals: Fifty-three dogs.