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Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice.
Am J Physiol Lung Cell Mol Physiol
June 2010
Department of Respiratory Medicine, Juntendo Univerity School of Medicine, Tokyo, Japan.
Vitamin C (VC) is a potent antioxidant and plays an essential role in collagen synthesis. As we previously reported, senescence marker protein-30 (SMP30) knockout (KO) mice cannot synthesize VC due to the genetic disruption of gluconolactonase (i.e.
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