297 results match your criteria: "Jungwon University[Affiliation]"

DeepDoublet identifies neighboring cell-dependent gene expression.

Genomics Inform

December 2024

Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Cells interact with each other for proper function and homeostasis. Often, co-expression of ligand-receptor pairs from the single-cell RNAseq (scRNAseq) has been used to identify interacting cell types. Recently, RNA sequencing of physically interacting multi-cells has been used to identify interacting cell types without relying on co-expression of ligand-receptor pairs.

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A Study on iPSC-Associated Factors in the Generation of Hepatocytes.

Tissue Eng Regen Med

December 2024

Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 406-840, Republic of Korea.

Background: Hepatocytes are an attractive cell source in hepatic tissue engineering because they are the primary cells of the liver, maintaining liver homeostasis through their intrinsic function. Due to the increasing demand for liver donors, a wide range of methods are being studied to obtain functionally active hepatocytes. iPSCs are one of the alternative cell sources, which shows great promise as a tool for generating hepatocytes.

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Article Synopsis
  • The study investigates the effects of COVID-19 mRNA vaccines on mice with chronic inflammatory conditions, especially their cardiac toxicity and immune response based on the administration route.
  • Results showed that intravenous (IV) mRNA vaccination can worsen heart conditions like pericarditis and myocarditis, leading to increased inflammation and damage, particularly in mice with existing chronic inflammation.
  • The findings emphasize the importance of more research to understand how mRNA vaccines interact with chronic inflammatory conditions, particularly focusing on the impact of different injection methods.
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Article Synopsis
  • * Researchers created liver-specific CAR knockout (KO) mice to explore CAR's role in the liver; although body weight didn't change, KO mice on a high-fat diet experienced more liver damage, inflammation, and lipid build-up compared to wild-type mice.
  • * The study identified a novel relationship between CAR and a protein called APOBEC3C, suggesting that CAR regulates lipid accumulation by affecting APOBEC3C levels
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Presoaking hamstring autograft with vancomycin does not jeopardize its biomechanical properties, including graft elongation, after cyclic loading.

Knee Surg Sports Traumatol Arthrosc

August 2024

Department of Anatomy, Catholic Institute for Applied Anatomy, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: Presoaking the graft with vancomycin before implantation has been shown to reduce the risk of postoperative infection after anterior cruciate ligament reconstruction (ACLR). However, the effects of presoaking on the graft biomechanical properties remain unclear. This study aimed to determine whether presoaking the graft with vancomycin affects the graft biomechanical properties and length after cyclic loading.

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This review aimed to determine the effectiveness of Intermittent Pneumatic Compression (IPC) intervention on Deep Vein Thrombosis (DVT) in surgical patients. An electronic database search was conducted with PubMed, OVID-MEDLINE, EMBASE, and CENTRAL, from September 22 to 28, 2023. Three researchers independently selected the studies, assessed their methodological quality, and extracted relevant data.

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Introduction: Despite its efficacy, conventional center-based cardiac rehabilitation has several limitations which have led to the emergence of home-based programs and intensive cardiac rehabilitation as alternative methods for overcoming these limitations. Alternative methods for primary prevention have been recommended for similar reasons. Lifestyle modification is considered key to success in both primary and secondary prevention.

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Impact of Illness Uncertainty on Health-Related Quality of Life in Patients With Unruptured Intracranial Aneurysms After Coil Embolization.

J Neurosci Nurs

October 2024

JiEun Lee, PhD RN, is Assistant Professor, Department of Nursing, Jungwon University, Goesan, Republic of Korea.

BACKGROUND: This study aimed to identify the impact of illness uncertainty on physical and mental health-related quality of life (HRQoL) in patients with unruptured intracranial aneurysms (UIAs) after coil embolization. METHODS: A cross-sectional study was conducted and HRQoL was evaluated using the Short Form-12 Health Survey Questionnaire, which assesses physical and mental HRQoL. RESULTS: The participants had a mean age of 56.

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Coxsackievirus B3 (CVB3) is a positive single-strand RNA genome virus which belongs to the enterovirus genus in the picornavirus family, like poliovirus. It is one of the most prevalent pathogens that cause myocarditis and pancreatitis in humans. However, a suitable therapeutic medication and vaccination have yet to be discovered.

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The purpose of this study was to examine the differences in specific physical fitness of the national amateur women's boxer. The Korean women's national amateur boxers were classified into the lightweight category (LWC, n=21) and middleweight category (MWC, n=13), and body composition (percentage body fat and body mass index) and specific physical fitness (maximal muscle strength, anaerobic power, isokinetic muscle strength, cardiopulmonary endurance) were measured. The Mann-Whitney -test was conducted to determine the differences in the body composition and specific physical fitness in women's boxers.

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In this study, we investigated the efficacy of kaempferol (a flavonoid found in plants and plant-derived foods such as kale, beans, tea, spinach and broccoli) on vascular contractibility and aimed to clarify the detailed mechanism underlying the relaxation. Isometric contractions of divested muscles were stored and linked with western blot analysis which was carried out to estimate the phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) and phosphorylation-dependent inhibitory protein for myosin phosphatase (CPI-17) and to estimate the effect of kaempferol on the RhoA/ROCK/CPI-17 pathway. Kaempferol conspicuously impeded phorbol ester-, fluoride- and a thromboxane mimetic-derived contractions regardless of endothelial nitric oxide synthesis, indicating its direct effect on smooth muscles.

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Sleep fragmentation (SF) can increase inflammation and production of reactive oxygen species (ROS), leading to metabolic dysfunction. SF is associated with inflammation of adipose tissue and insulin resistance. Several studies have suggested that melatonin may have beneficial metabolic effects due to activating AMP-activated protein kinase (AMPK).

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Objectives: We investigated the association between metabolic syndrome (MetS) and the coexistence of insomnia and daytime napping, because limited data have been reported regarding this association.

Methods: The study population was 8,440 participants aged 40-65 years, who were from the Korean Genome and Epidemiology Study. Self-reported information on insomnia symptoms and nap duration was used to define exposure variables.

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Highly accurate traffic flow prediction is essential for effectively managing traffic congestion, providing real-time travel advice, and reducing travel costs. However, traditional traffic flow prediction models often fail to fully consider the correlation and periodicity among traffic state data and rely on static network topology graphs. To solve this problem, this paper proposes a expressway traffic flow prediction model based on multi-feature spatial-temporal adaptive periodic fused graph convolutional network (MFSTAPFGCN).

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Assessing the impact of mRNA vaccination in chronic inflammatory murine model.

NPJ Vaccines

February 2024

Department of Medical and Biological Sciences, The Catholic University of Korea, Gyeonggi-do, Bucheon, Republic of Korea.

Article Synopsis
  • The study examines how mRNA vaccines affect individuals with chronic inflammatory diseases (like myocarditis, rheumatoid arthritis, and inflammatory bowel disease) using a mouse model with chronic inflammation.
  • Results showed that mRNA vaccines increased cardiac damage and mild heart inflammation, along with significant muscle damage, although the vaccination site and overall immune responses were less impacted.
  • The findings highlight the need to consider the safety and effectiveness of mRNA vaccines for people with chronic inflammatory conditions, as they may experience different toxicities and immune responses.
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Flame-Retardant Behavior and Nanocrystal Synthesis through Formation of Multilayers of Poly(acrylic acid) and Zinc Phosphate on Cotton Fabric.

ACS Omega

February 2024

Dept. of Materials Science and Engineering, Jungwon University, 85 Munmu-ro Goesan-eup, Goesan-gun 28024, Republic of Korea.

Cotton fabric with improved flame retardancy was prepared by introducing a zinc phosphate compound into cotton fabric using a layer-by-layer (LBL) deposition method with poly(acrylic acid) as a polymer electrolyte layer. In a vertical burning (VB) test, it was found that the flame retardancy improved as the number of depositions increased. As a result of thermogravimetric and inductively coupled plasma-atomic emission spectroscopy analyses, the residual amount increased to 20 wt % for the 20 deposited sample, and the weight ratio of Zn and P elements reached more than 40 wt %.

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Aortic aneurysms: current pathogenesis and therapeutic targets.

Exp Mol Med

December 2023

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.

Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta, including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic aneurysms are generally asymptomatic, they can threaten human health by sudden death due to aortic rupture. Aortic aneurysms are estimated to lead to 150,000 ~ 200,000 deaths per year worldwide.

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Alternative Clinical Practice Experiences of Korean Nursing Students during the COVID-19 Pandemic.

Healthcare (Basel)

September 2023

Department of Nursing, Jungwon University, Goesan-gun 28024, Republic of Korea.

Routine clinical practice (RCP) experiences provide nursing students with the opportunity to gain confidence in their professional roles. The purpose of this study was to explore the alternative clinical practice (ACP) experiences of nursing students during the COVID-19 pandemic using the Q methodology. Fifty-two nursing students located in four cities across South Korea participated.

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(DM), a medicinal plant, is rich in polyphenols and commonly used to treat cancer, inflammation, and thrombosis. However, to date, no study has been conducted on DM regarding the enormous drift of secondary metabolites of plants in different regions of the Republic of Korea and their effects on antiobesity, to explore compounds that play an important role in two major obesity-related pathways. Here, we present an in-depth study on DM samples collected from three regions of the Republic of Korea [Jeju Island (DMJ), Bogildo (DMB), and Jangheung (DMJG)].

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Oral Administration of Human-Gut-Derived Improves Sleep Architecture in Rats.

Microorganisms

April 2023

Department of Foods and Nutrition, College of Science and Technology, Kookmin University, Seoul 02707, Republic of Korea.

(1) Background: The human gut microbiome may regulate sleep through the gut-brain axis. However, the sleep-promoting effects of gut microbiota remain unclear. (2) Methods: We obtained sleep-wake profiles from 25 rats receiving ( group), 5 rats receiving ( group), 4 rats not receiving bacteria (No administration group), and 8 rats receiving extracellular vesicles (EV) (EV group) during the baseline, administration, and withdrawal periods.

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Optimal hinge level in opening wedge high tibial osteotomy: Biomechanical analysis using finite element method.

Clin Biomech (Bristol)

July 2023

Department of Orthopedic Surgery, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea; Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: While the concept of a safe zone, which can minimize the hinge fracture when performing opening wedge high tibial osteotomy, has been introduced, there is a lack of understanding of the biomechanical environment at the lateral tibial cortex. This study aimed to evaluate the effect of the hinge level on the biomechanical environment at the lateral cortex of the tibia with heterogeneous finite element models.

Methods: Finite element models of biplanar opening wedge high tibial osteotomy based on computed tomography images of a control subject and three patients with medial compartment knee osteoarthritis were created.

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Twenty core nursing skills have been identified by the Korean Accreditation Board of Nursing Education. Proficiency in these skills is essential for all nursing professions, and many educational strategies exist to develop these skills in nursing students, including the Objective Structured Clinical Examination (OSCE). To date, no study on the effects of the OSCE on nursing education has been published.

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Fractures cause extreme pain to patients and impair movement, thereby significantly reducing their quality of life. However, in fracture patients, movement of the fracture site is restricted through application of a cast, and they are reliant on conservative treatment through calcium intake. Persicae semen (PS) is the dried mature seeds of (L.

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The coxsackievirus and adenovirus receptor (CAR) is very well known as an epithelial tight junction and cardiac intercalated disc protein; it mediates attachment and infection via the coxsackievirus B3 (CVB3) and type 5 adenovirus. Macrophages play important roles in early immunity during viral infections. However, the role of CAR in macrophages is not well studied in relation to CVB3 infection.

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