1 results match your criteria: "Julius Maximilians University Medical Centre of Wx00FC;rzburg[Affiliation]"
Metformin-Derived Growth Inhibition in Renal Cell Carcinoma Depends on miR-21-Mediated PTEN Expression.
Urol Int
December 2016
Department of Urology and Paediatric Urology, Julius Maximilians University Medical Centre of Wx00FC;rzburg, Wx00FC;rzburg, Germany.
Purpose: Metformin (MF) acts as a tumour-suppressor in renal cell carcinoma (RCC) by inhibiting the AKT/mTOR pathway via AMPK activation. Here, we explore the influence of miR-21 and its target gene PTEN on MF effects in CAKI-1 and CAKI-2 cells.
Methods: Proliferation assays (MTS) and qRT-PCR after transient transfection with pre- and anti-miR-21 and MF treatment were conducted.