806 results match your criteria: "Jules Verne University[Affiliation]"

Background: Cardiac surgery can lead to dysregulation with a pro-inflammatory state, resulting in adverse outcomes. Hemadsorption using the AN69 membrane (Oxiris membrane) has the properties to chelate inflammatory cytokines. We hypothesized that in patients at high risk of inflammation, the use of the Oxiris membrane could decrease inflammation, preserve endothelial function, and improve postoperative outcomes.

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Background: The serum calcification propensity test (or T50 test) might become a standard tool for the assessment of vascular calcification risk and T50 might be a valuable biomarker in clinical trials of treatments intended to slow the progression of vascular calcification. Literature data suggest that non-calcium-containing phosphate binders can influence T50 in chronic dialysed patients. However, it is not clear whether similar interventions are effective in patients at earlier stages of chronic kidney disease (CKD).

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Background: We sought to comprehensively describe drug-related components associated with acute kidney injury (AKI) in patients with chronic kidney disease (CKD), describing the incidence of drug-related AKI, the proportion of preventable AKI, identified the various drugs potentially associated with it, explored the risk factors, and assessed the 1-year incidences of the recurrence of drug-related AKI, kidney failure, and death.

Methods: CKD-REIN is a French national prospective cohort of 3033 nephrology outpatients with a confirmed diagnosis of CKD (eGFR <60 ml/min/1.73 m²).

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Association between urate-lowering therapy and kidney failure in patients with chronic kidney disease.

J Nephrol

January 2025

Pharmacoepidemiology Unit, Department of Clinical Pharmacology, Amiens-Picardie University Medical Center, CHU Amiens-Picardie, Rond-Point du Professeur Christian Cabrol, 80054, Amiens Cedex, France.

Background: Hyperuricemia is a hallmark of gout and a suspected risk factor for the progression of chronic kidney disease (CKD). However, the impact of urate-lowering therapy on CKD progression is subject to debate. The objective of the present study was to describe the prevalence of inappropriate urate-lowering therapy prescriptions and evaluate the association between urate-lowering therapy prescription and the progression of kidney disease in patients with CKD.

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Fortuitous discovery of a superior and posterior pancreaticoduodenal artery originating from the right branch of the hepatic artery during cadaver dissection.

Morphologie

January 2025

Department of Digestive Surgery, Amiens Picardy University Hospital, 1, rondpoint du Pr-Cabrol, 80054 Amiens, France; Simplifying Care for Complex Patients, UR-UPJV 7518 SSPC, Clinical Research Unit, University of Picardie Jules-Verne, Amiens, France.

Introduction: The duodeno-pancreatic region is a highly vascularized area. The superior and posterior pancreaticoduodenal artery is a vessel primarily originating from the gastroduodenal artery. It exhibits rare anatomical variations, such as its emergence from the right branch of the hepatic artery, which we fortuitously identified during a cadaver dissection.

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Background: The pressure gradient between the ventricles and the subarachnoid space (transmantle pressure) is crucial for understanding CSF circulation and the pathogenesis of certain neurodegenerative diseases. This pressure can be approximated by the pressure difference across the aqueduct (ΔP). Currently, no dedicated platform exists for quantifying ΔP, and no research has been conducted on the impact of breathing on ΔP.

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Introduction: Numerous studies have explored the linguistic and executive processes underlying verbal fluency using association designs, which provide limited evidence. To assess the validity of our model, we aimed to refine the cognitive architecture of verbal fluency using an interference design.

Methods: A total of 487 healthy participants performed letter and semantic fluency tests under the single condition and dual conditions while concurrently performing a secondary task that interferes with speed, semantics, phonology, or flexibility.

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Prenatal Diagnosis of Proteus Syndrome: About a Case.

Am J Med Genet A

December 2024

Constitutional Genetics Laboratory, CHU Amiens Picardie, Amiens, France.

Proteus syndrome (PS) is a rare disorder (< 1/1000000), marked by progressive overgrowth commonly impacting the skeleton, skin, adipose tissue, and central nervous system. Clinical criteria were established in 2019. PS arises from a somatic activating variation in the AKT1 gene.

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Background: The prevalence and impact of right ventricular dysfunction (RVD) in degenerative mitral regurgitation (DMR) is unknown. We aimed to determine whether RVD assessed by echocardiography in routine clinical practice is independently associated with mortality in patients with DMR.

Methods And Results: We used data from the MIDA-Q (Mitral Regurgitation International DAtabase-Quantitative) registry, which included patients with isolated DMR due to mitral valve prolapse from January 2003 to January 2020 from 5 tertiary centers across North America, Europe, and the Middle East.

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Acute kidney injury as a key predictor of cardiovascular events in chronic kidney disease patients: the CKD-REIN study.

Clin Kidney J

December 2024

Public Health Department, Epidémiologie - Maison régionale de la recherche clinique, CHU Lille, Lille, France.

Background And Hypothesis: Cardiovascular diseases are a leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Acute kidney injury (AKI) has been increasingly recognized as a potential exacerbating factor for cardiovascular events in these patients. The CKD-REIN study aims to explore the relationship between AKI and the risk of major adverse cardiovascular events (MACE) in a cohort of CKD patients.

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Modifying Our Environment to Improve Outcomes in Inflammatory Bowel Diseases?

United European Gastroenterol J

December 2024

Department of Gastroenterology, University Rouen Normandie, INSERM, ADEN UMR1073, "Nutrition, Inflammation and Microbiota-Gut-Brain Axis", CHU Rouen, Rouen, France.

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Heparin-induced thrombocytopenia (HIT) is an adverse reaction characterized by anti-PF4-heparin antibody generation and hypercoagulability. Imaging flow cytometry (IFC) provides a detailed morphological analysis of platelets, which change upon activation. We evaluated IFC-derived morphometric features to detect platelet activation and developed a functional assay for HIT diagnosis.

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Cognitive impairments after maximal repeated breath-holding in elite breath-hold divers.

J Sports Med Phys Fitness

December 2024

Center for the Study of Changes in Physical and Sports Activities, Faculty of Sport Sciences and Physical Education of Rouen, University of Rouen, Rouen, France.

Background: Breath-hold (BH) training over several years may result in mild but persistent neurocognitive impairment. Paradoxically, the acute effects of repeated BH generating intermittent hypoxia on neurocognitive functions are still poorly understood. Therefore, we decided to examine the impact of five-repeated maximal BH on attention, processing speed, and reasoning abilities.

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Wild-type transthyretin cardiac amyloidosis and aortic stenosis: Can carpal tunnel syndrome help distinguish the chicken from the egg?

J Intern Med

November 2024

Referral Center for Cardiac Amyloidosis, Mondor Amyloidosis Network, GRC Amyloid Research Institute and Cardiology Department, APHP Henri Mondor Hospital, Créteil, France.

Article Synopsis
  • - The study investigates the relationship between transthyretin wild-type cardiac amyloidosis (TTRwt-CA) and aortic stenosis (AS), proposing a bidirectional connection where each condition may influence the other and lead to systemic manifestations, including carpal tunnel syndrome (CTS).
  • - In a sample of 411 TTRwt-CA patients, approximately 70% had CTS, which correlated with younger age, more severe cardiac remodeling, and a higher frequency of extracardiac symptoms, while AS occurred in 21% of those with CTS and 31% without.
  • - The research indicates that CTS may differentiate two phenotypes of TTRwt-CA: one associated with systemic involvement and poorly calcified low-flow
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Laser interstitial thermal therapy (LITT) is a minimally invasive surgical treatment for drug-resistant, focal epilepsies. With MRI guidance, LITT can also be used to treat hypothalamic hamartoma. Here, we report on the first European case of LITT for hypothalamic hamartoma.

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Article Synopsis
  • People with chronic kidney disease (CKD) face a higher risk of cognitive impairment (CI), and this study investigates the link between anticholinergic medications and cognitive performance in CKD patients.
  • The research involved a prospective cohort study of 3007 nephrology outpatients, where data on medication prescriptions and cognitive function were collected over five years.
  • Findings revealed that over half of the participants were prescribed anticholinergic drugs, with those having a high anticholinergic burden more likely to experience cognitive impairment, particularly if they had a history of neurological disorders or were on multiple medications.
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Antihypertensive Treatment Patterns in CKD Stages 3 and 4: The CKD-REIN Cohort Study.

Kidney Med

December 2024

Centre for Research in Epidemiology and Population Health, Paris-Saclay University, Inserm U1018, Versailles Saint-Quentin University, Clinical Epidemiology Team, Villejuif, France.

Article Synopsis
  • Blood pressure (BP) control is crucial for preventing complications in chronic kidney disease (CKD), yet many patients struggle to reach target levels; this study evaluates how antihypertensive prescriptions change over time in CKD patients.
  • Conducted with 2,755 hypertensive CKD patients in France, the study tracked factors influencing prescription changes, such as patient demographics and healthcare provider interactions.
  • Results showed that over five years, there was a high rate of changes in medication; poor adherence to medications increased the likelihood of needing additional drugs, while having a lower education level led to more frequent withdrawals of antihypertensive medications.
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Background: Clinical decision support systems (CDSSs) enable the automated, real-time detection of situations associated with a risk of adverse drug events (ADEs). However, the effectiveness of CDSS in reducing ADEs has yet to be demonstrated. We have chosen to focus on the detection of ADE such as hyperkalemia and/or acute kidney injury (AKI), which are common among hospitalized older adults.

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Severe hypophosphatemia induced by excessive production of FGF23 in acute hepatitis: from bedside to bench.

Clin Kidney J

November 2024

Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity, Plasticity and Resistance to Therapies, Lille, France.

Background: Although hepatic production of FGF23 has been suggested in chronic settings, there are no data indicating hypophosphatemia resulting from acute hepatic FGF23 production. Based on two clinical observations of profound hypophosphatemia in the setting of acute hepatitis, our study investigates the hypothesis of acute FGF23 liver expression.

Methods: Retrospective analyses were conducted to estimate FGF23 liver expression both qualitatively ( hybridization) and quantitatively (relative FGF23 gene expression and protein production) on histological specimens of human and murine acute hepatitis livers, compared with controls of hepatic fibrosis or healthy liver.

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Urinary schistosomiasis: The Corsican file.

Fr J Urol

October 2024

Department of Parasitology and Mycology, CBH, CHUAP, Amiens, France; Agents Infectieux, Résistance et Chimiothérapie (AGIR), UR 4294, Picardie Jules-Verne University, Amiens, France.

Schistosomiasis, known as bilharzia, is a parasitic disease caused by trematodes of the genus Schistosoma, found primarily in Africa and pockets of the Middle East. Southern Europe seems to be a breeding ground for urogenital schistosomiasis emergence. Ten and five years have passed since the first and the last cases of urogenital schistosomiasis were identified in Corsica (patients who have bathed in the Cavu and/or Solenzara rivers between 2013 and 2019).

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Is an excessively high posterior tibial slope a predisposition to knee injuries in children? Systematic review of the literature.

Orthop Traumatol Surg Res

October 2024

Service d'Orthopédie et Traumatologie Pédiatrique, CHU Amiens-Picardie, 80054, Amiens Cedex 1, France; GRECO (Groupement de Recherche et d'Etudes en Chirurgie Robotisée), Amiens University Hospital and Jules Verne University of Picardie, Amiens, France.

Article Synopsis
  • * Out of 294 identified studies, 11 were included, which highlighted a significant correlation between elevated PTS and ACL injuries, showing an increase in PTS by 2.1° to 4.3° in affected patients compared to healthy individuals.
  • * The findings suggest that a high PTS may be linked to an increased risk of knee pathologies in children, necessitating careful consideration when assessing young athletes with ACL injuries.
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Background: Following the Monro-Kellie doctrine, the Cerebral Blood Volume Changes (CB_VC) should be mirrored by the Cerebrospinal Fluid Volume Changes (CSF_VC) at the spinal canal. Cervical level is often chosen to estimate CB_VC during the cardiac cycle. However, due to the heterogeneity in the anatomy of extracranial internal jugular veins and their high compliance, we hypothesize that the intracranial level could be a better choice to investigate blood and cerebrospinal fluid (CSF) interactions.

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Article Synopsis
  • The study investigates the presence of human papillomavirus (HPV) in the semen of men seeking infertility treatment at Amiens University Hospital from May to October 2021, involving 461 participants who provided informed consent.
  • Semen samples were analyzed for HPV using PCR, revealing that 22.3% of men carried HPV, with high-oncogenic-risk types being the most common (57.6%).
  • The analysis found significant associations between HPV carriage and factors like abnormal sperm quality, type of infertility, presence of varicocele, and certain testicular conditions, indicating that HPV may contribute to infertility risks.
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