Lymphocytic Esophagitis Associated With Chronic Severe Psoriasis: A Case Report With Special Reference to Programmed Death-Ligand 1 Expression.

Lymphocytic esophagitis (LE) is a rare type of chronic esophagitis, marked by an increased number of peripapillary intraepithelial lymphocytes (IEL) with little to no presence of intraepithelial granulocytes and intercellular edema. There is currently no established standard for quantifying IEL in the esophageal mucosa. Clinically, LE manifests with a range of symptoms, including difficulty swallowing (dysphagia), indigestion (dyspepsia), nausea, and chest pain.

Quiz CORRECT ANSWER TO THE QUIZ. CHECK YOUR DIAGNOSIS Prostatic paraganglia-hyperplasia - a histological mimic of intraprostatic adipose tissue.

Prostatic paraganglia (PP) can simulate adenocarcinoma's fused gland pattern, and a differential diagnostic panel is developed. Their differential diagnosis with benign prostatic lesions has been largely unreported. Intraprostatic adipose tissue (IPAT) is seen extremely rarely in prostatic specimens, but it must be known, to avoid false positive results for extraprostatic fat carcinomatous invasion in needle biopsy specimens.

Evidence of Programmed Death-Ligand 1 Expression in a Highly Inflammatory Prostate: A Literature Review and Our Experience.

Chronic inflammation (CI), a common finding in the human prostate, is associated with the most frequent socially important prostate diseases: prostatitis, benign prostatic hyperplasia, and prostate adenocarcinoma. Programmed cell death protein 1 (PD-1) and its ligand (PD-L1) expression are induced on the surface of immune and epithelial cells of healthy and tumor tissues in response to various cytokines. Here, we provide a comprehensive review of the PD-1/PD-L1 pathway in the non- and peri-tumoral inflammatory prostate, focusing on the structure and expression of PD-L1 and the diverse biological functions of PD-L1 signaling in health, high-grade CI (National Institutes of Health, category IV prostatitis or histologic prostatitis), and immune-related diseases, including autoimmunity, tumor microenvironmental immunity, and immune privilege.

Pediatric Acute Alcohol Intoxication Admitted to the ICU: A Review of 102 Cases in France.

Objectives: To describe the profile and clinical outcomes of children (<18 yr) admitted to intensive care for acute alcohol intoxication, with special attention to complications and to the subgroup that required intubation.

Design: Retrospective observational study.

Setting: Seven pediatric and three adult ICUs in France.

Fertility preservation in women with malignant and borderline ovarian tumors: Experience of the French ESGO-certified center and pregnancy-associated cancer network (CALG).

Objective: To describe strategy and results of fertility preservation (FP) in patients with malignant and borderline ovarian tumors.

Methods: Consecutive cohort study of 43 women with malignant or borderline ovarian tumors who underwent FP between February 2013 and July 2019. The study was conducted in national expert center in Tenon University Hospital, Sorbonne University: French ESGO-certified ovarian cancer center and pregnancy-associated cancer network (CALG).

Eosinophilic metaplasia in transurethral resection of the prostate.

Background: To investigate prostatic eosinophilic metaplasia (EM) in a large series of cases and their relationship with the basic prostate pathology in TURP-material: benign prostatic hyperplasia (BPH), National Institutes of Health category IV prostatitis (also called histologic prostatitis or HP), and prostatic adenocarcinoma (PCa).

Aim: The relation between EM and basic prostate pathology: BPH, PCa, and HP.

Materials And Methods: Around 61 consecutive TURP-specimens were reviewed for the presence of EM.

Nonspecific granulomatous prostatitis in association with eosinophilic epithelial metaplasia and prostatic adenocarcinoma.

We present the first case of nonspecific granulomatous prostatitis (NSGP) associated with both eosinophilic epithelial metaplasia (EM) in benign glands and prostatic adenocarcinoma (PCa). The patient was a 68-year old man with a history of obstructive prostatic syndrome. After a transurethral resection of the prostate, the histologic analysis revealed NSGP and PCa.