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Orthogonal control of expression mean and variance by epigenetic features at different genomic loci.

Mol Syst Biol

May 2015

Department of Bioengineering, University of California, Berkeley, CA, USA Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA Virtual Institute of Microbial Stress and Survival, Lawrence Berkeley National Laboratory, Berkeley, CA, USA DOE, Joint BioEnergy Institute Lawrence Berkeley National Laboratory, Berkeley, CA, USA

While gene expression noise has been shown to drive dramatic phenotypic variations, the molecular basis for this variability in mammalian systems is not well understood. Gene expression has been shown to be regulated by promoter architecture and the associated chromatin environment. However, the exact contribution of these two factors in regulating expression noise has not been explored.

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