839 results match your criteria: "John Paul II Catholic University[Affiliation]"

Kynurenic acid (KYNA) is a metabolite of tryptophan formed on the kynurenine pathway. Its pharmacological effects are relatively well characterized in mammals, whereas its role in fish is poorly understood. Therefore, the aim of the study was to expand the knowledge of KYNA's presence inside a fish's body and its impact on fish development and function.

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Application of proteomics for novel drug discovery and risk prediction optimisation in stroke and myocardial infarction: a review of in-human studies.

Drug Discov Today

November 2024

Department of Twin Research, King's College London, London, UK; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK. Electronic address:

The use of proteomics in human studies investigating stroke and myocardial infarction (MI) has been increasing, prompting a review of the literature. This revealed proteinaceous biomarkers of stroke from thrombi, brain tissue, cells, and particles, some of which cross the blood-brain barrier (BBB). Several proteins were also implicated in coronary artery disease (CAD), which often underlies MI, cholesterol transportation, and inflammation.

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Removal of polyphenols from anthocyanin-rich extracts using 4-vinylpyridine crosslinked copolymers.

Food Chem

January 2025

Department of Chemistry, Institute of Biological Sciences, Faculty of Medicine, Collegium Medicum, The John Paul II Catholic University of Lublin, Konstantynów 1J, 20-708 Lublin, Poland. Electronic address:

In this work, new sorbents for the purification of anthocyanin-rich extracts were evaluated. Copolymers of 4-vinylpyridine crosslinked with trimethylolpropane trimethacrylate (poly(4VP-co-TRIM)) or 1,4-dimethacryloyloxybenzene (poly(4VP-co-14DMB)) were tested for their potential to capture polyphenols. Copolymers were obtained by seed swelling polymerization in the form of microspheres with permanent porous structure - attractive features of sorbents used for sample purification by dispersive solid phase extraction.

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The article raises the issue of the quality of life (QoL) of adolescents during the COVID-19 pandemic, its relationships with coping and mediating role of the received social support (RSS). The nationwide survey was conducted from September 13, 2021 to October 1, 2021. The total of 4970 individuals aged 10-18 years old were researched in Poland.

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Article Synopsis
  • Plants contain a wide variety of secondary metabolites, with phenolic compounds being the most prevalent; over 8000 types of polyphenols have been identified, including phenolic acids, flavonoids, and lignans.
  • Acne, particularly acne vulgaris and rosacea, is one of the most commonly treated skin conditions, yet there's limited research on how plant phenolics can help in its treatment.
  • The review reveals that phenolic compounds, known for their antibacterial, anti-inflammatory, and antioxidant properties, may be effective in treating acne, especially when combined with standard medications; compounds like EGCG, quercetin, and nobiletin show promise, although more clinical studies are needed to confirm their effectiveness.
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The study aimed to determine whether self-efficacy acts as a moderator between the severity of menopausal symptoms and life satisfaction. The research tools were: The Generalized Self-Efficacy Scale (GSES), The Satisfaction with Life Scale (SWLS) The Menopause - Specific Quality of Life (MENQOL), and a standardized questionnaire comprising questions on the participants' characteristics. 516 women using health care services who had menopausal symptoms took part in the study.

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Aim: To assess the level of stress of conscience experienced by Polish nurses and midwives and its determinants.

Design: Descriptive cross-sectional study.

Methods: The study was conducted from March 2019 to December 2020 and included convenience sampling of nurses and midwives working in hospitals in south-eastern Poland.

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Do aluminum, boron, arsenic, cadmium, lipoperoxidation, and genetic polymorphism determine male fertility?

Ecotoxicol Environ Saf

October 2024

Nicholaus Copernicus University, Collegium Medicum in Bydgoszcz, Department of Medical Biology and Biochemistry, M. Karłowicz St. 24, Bydgoszcz PL 85-092, Poland. Electronic address:

Male infertility is a world multifactorial problem modulated by environmental and genetic factors. Male aspects account for 20-50 % of infertility cases. Our results are unique because they treat the importance of components participating in the determination of male infertility (environmental and immunogenetic determinants, seminological analysis, lipoperoxidation, genetic determinants, role of aluminum, arsenic, cadmium and boron).

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Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease.

Int J Mol Sci

August 2024

Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, ul. Jaczewskiego 4, 20-090 Lublin, Poland.

Alzheimer's disease (AD) is characterized by, among other things, dementia and a decline in cognitive performance. In AD, dementia has neurodegenerative features and starts with mild cognitive impairment (MCI). Research indicates that apoptosis and neuronal loss occur in AD, in which oxidative stress plays an important role.

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Omega-3 Polyunsaturated Fatty Acids in Depression.

Int J Mol Sci

August 2024

Department of Clinical Pharmacy and Pharmaceutical Care, Medical University of Lublin, Chodźki Street 7, 20-093 Lublin, Poland.

Omega-3 polyunsaturated fatty acids have received considerable attention in the field of mental health, in particular regarding the treatment of depression. This review presents an overview of current research on the role of omega-3 fatty acids in the prevention and treatment of depressive disorders. The existing body of evidence demonstrates that omega-3 fatty acids, in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have antidepressant effects that can be attributed to their modulation of neuroinflammation, neurotransmitter function, and neuroplasticity.

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Religious struggles tend noticeably to influence the sphere of social well-being in emerging adulthood as individuals modify their religious beliefs and practices, form personal identity patterns, and rediscover new life purpose and values. The aim of the current study was to investigate whether meaning-making and meaning in life (presence and search) can serially mediate the hypothesized links between religious comfort vs. strain and social well-being.

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Facebook is one of the most popular social networking sites. However, Facebook intrusion or addiction is a growing concern as it involves an excessive attachment to Facebook, which disrupts daily functioning. To date, few studies have examined whether cross-cultural differences in the measurement of Facebook addiction exist.

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Some students suffer from math anxiety and experience negative emotions in mathematics education. Children's math anxiety is negatively related to their math achievement, suggesting that math anxiety puts their math learning at risk. Several theoretical accounts have been proposed that help to explain this association between math anxiety and achievement.

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A novel library of naphthoquinone derivatives (3-5 aa) was synthesized and evaluated for their anticancer properties. Specifically, compounds 5 i, 5 l, 5 o, 5 q, 5 r, 5 s, 5 t, and 5 v demonstrated superior cytotoxic activity against the cancer cell lines that were studied. All the studied compounds exhibited a higher selectivity index (SI) and a favourable safety profile than the standard drug doxorubicin.

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4-Vinylpyridine copolymers for improved LC-MS tryptophan and kynurenine determination in human serum.

Sci Rep

August 2024

Department of Chemistry, Institute of Biological Sciences, Faculty of Medicine, the John Paul II Catholic University of Lublin, Konstantynów 1J, 20-708, Lublin, Poland.

Article Synopsis
  • Tryptophan and its metabolite kynurenine are important for various biological processes, sparking interest in their detection methods in biological samples.
  • This study highlights the effectiveness of two specially designed polymers for cleaning human serum, specifically poly(4VP-co-TRIM), which effectively reduces interference during the measurement of tryptophan and kynurenine using liquid chromatography-mass spectrometry (LC-MS).
  • Results showed that poly(4VP-co-TRIM) achieved good recovery rates (76% for tryptophan and 87% for kynurenine) and outperformed some common commercially available sorbents in minimizing matrix effects.
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Purpose: This study aims to adapt and verify the psychometric properties of the Craving for Internet Gaming Scale (CIGS) in a Polish sample. Craving, although observed as significantly associated with Internet Gaming Disorder, is not currently included in its diagnostic criteria. This research addresses the need for scales to measure craving in this particular context.

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Article Synopsis
  • - Echocardiography in neonates helps identify congenital heart defects and provides a 3-vessel view (3VV) to visualize the relationship between major blood vessels and the thymus gland.
  • - A preliminary study collected and analyzed 1,331 thymus records from both preterm (321) and full-term (1,010) neonates, measuring thymus width, depth, and the thymic 3VV index (TI 3VV).
  • - Findings showed that thymus dimensions correlate with body weight, gestational age, and body surface area; specifically, thymus depth can serve as an effective screening measure for assessing thymus size.
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Article Synopsis
  • The cult of saints in Western Europe emerged during late antiquity and the early Middle Ages, where they played a crucial role in providing medical hope to people who lacked access to doctors.
  • People prayed to specific saints for healing, leading to the emergence of "specialized" saints who were believed to treat different skin issues and wounds.
  • Research explored the connection between the cult of saints and the establishment of hospitals, focusing on saints related to skin diseases, including patrons of animal bites, wounds, and contagious diseases like leprosy and scabies.
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Background: In the context of discussions between supporters and opponents of euthanasia, and legal regulations regarding this type of practices, the attitude of young people with respect to this phenomenon is a very interesting issue. According to Polish law, euthanasia is prohibited. The aim of this study was to determine the degree of acceptance of euthanasia among students from Polish universities across three different fields of study: psychology, medicine, and economic-technical disciplines, and to identify the factors associated with the acceptance of this phenomenon.

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Lipoxygenase activity and localization vary throughout the development of Larix kaempferi ovules, with the highest enzyme activity observed in ovules at the cellular stage and the most intense immunogold reaction noted at the mature archegonium stage of gametophyte development. Lipoxygenases are a family of oxidoreductases with a significant role in biological systems, widespread in living organisms e.g.

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Objective: The stress experienced by a woman during pregnancy not only has a negative impact on her well-being and physical health but also adversely affects the fetus. Stress is strongly linked with time perspective, defined as the tendency to focus on the past, present, or future. The study aimed to investigate how couples' balanced time perspective was related to maternal prenatal hair cortisol concentration and perceived stress in the first and third trimesters of pregnancy.

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Heterocyclic compounds, particularly those containing azole rings, have shown extensive biological activity, including anticancer, antibacterial, and antifungal properties. Among these, the imidazole ring stands out due to its diverse therapeutic potential. In the presented study, we designed and synthesized a series of imidazole derivatives to identify compounds with high biological potential.

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The ice phenology as a predictor of bloom in vegetation season in temperate lakes.

Front Microbiol

June 2024

Laboratory of Research and Nature Protection, Krzczonów, Poland.

Introduction: Global warming affects air and water temperatures, which impacts the phenology of lakes and aquatic ecosystems. These changes are most noticeable during winter, when the potentially toxic forms its inoculum for annual blooms. Mostly, research has been conducted on alpine lakes, where blooms have persisted for decades, while a few have focused on temperate lakes.

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