5,858 results match your criteria: "John A. Burns School of Medicine[Affiliation]"

A Survey of US Collegiate Student-Athletes and Athletic Trainers on Sports-Related Concussion Knowledge and Reporting Habits.

Clin J Sport Med

December 2024

Department of Family Medicine and Community Health, Sports Medicine Fellowship Program, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, Hawai'i; and.

Objective: To assess sports-related concussion (SRC) knowledge levels in US collegiate student-athletes (S-As) and athletic trainers (ATs) and identify factors that influence reporting of SRC by S-As.

Design: Cross-sectional, retrospective study.

Setting: University training room/clinic visits.

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Formal assessment of What Matters in end-of-life care is often done in medical settings through legal forms. Past research indicates that Native Hawaiians are less likely to complete these forms than Whites. The purpose of this study was to explore health care preferences among Native Hawaiian elders and to identify cultural themes that may impact quality care at end of life.

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Investigating the binding of fluorescent probes to a trypanosomal-tRNA synthetase: A fluorescence spectroscopic and molecular dynamics study.

Arch Biochem Biophys

December 2024

Department of Biotechnology and Dr. B. C. Guha Centre for Genetic Engineering and Biotechnology, University of Calcutta, Kolkata, India. Electronic address:

Given the high prevalence of Chagas disease in the Americas, we targeted the unique arginyl-tRNA synthetase of its causative agent Trypanosoma cruzi. Among their many possible uses, naphthalene-derived fluorescent ligands, such as ANS and bis-ANS, may be employed in pharmacokinetic research. Although ANS and bis-ANS have become prominent fluorescent probes for protein characterization, the structural and spectroscopic characteristics of protein-ANS/bis-ANS complexes remain largely unknown.

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Background: This study evaluated the impact of the mentorship model used in the psychiatry clerkship at Nassau University Medical Center (NUMC), with a focus on its effectiveness in improving medical knowledge and professional development in psychiatry.

Methods: This survey-based study at NUMC involved 16 attending psychiatrists and 13 past medical student mentees. Data were collected via electronic surveys from March to May 2022, examining effectiveness of mentorship and mentees' experiences.

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DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility.

Aging (Albany NY)

December 2024

Department of Molecular, Cell and Developmental Biology, Life Sciences Division, University of California, Los Angeles, CA 90095, USA.

Background: DNA methylation (DNAm)-based marker of aging, referred to as 'epigenetic age' or 'DNAm age' is a highly accurate multi-tissue biomarker for aging, associated with age-related disease risk, including cancer. Breast cancer (BC), an age-associated disease, is associated with older DNAm age and epigenetic age acceleration (age accel) at tissue levels. But this raises a question on the predictability of DNAm age/age accel in BC development, emphasizing the importance of studying DNAm age in pre-diagnostic peripheral blood (PB) in BC etiology and prevention.

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Background: The mean age of volleyball athletes has increased over the past decade, raising concerns about musculoskeletal injuries. There is no literature on how different mechanisms of injury (MOI) affect different adult age groups.

Purpose: To evaluate epidemiologic trends, diagnoses, and mechanisms of volleyball-related upper extremity injuries within different adult age groups.

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Background: Wrestling is among the most common youth sports in the United States, with about 260,000 high school participants annually. There is a lack of literature investigating wrestling injury profiles and mechanisms of injuries. In the past 15 years, urgent care utilization has increased, and National Federation of State High School Associations (NFHS) concussion protocols have been developed and implemented.

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Article Synopsis
  • The study investigates how mothers of adolescents use social media and its impact on their hesitancy regarding the HPV vaccine.
  • A national survey of 3,968 mothers revealed that while Facebook had a negative association with HPV vaccine hesitancy, uncertainty about social media messages increased hesitancy.
  • The findings suggest that healthcare providers can play a crucial role in addressing vaccine hesitancy and emphasize the need for further research into effective social media strategies to promote HPV vaccination among teens.
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Introduction: This study aims to assess various models of psychological debriefing, their benefits, and the impact of their implementation on medical trainees & healthcare professionals' stress management skills, mental well-being, and clinical performance.

Methods: This review queried PubMed, ProQuest, Web of Science, and Google Scholar databases for articles regarding psychological debriefing in medical education published through May 2024. Included studies that assessed the utilization, implementation, and effectiveness of various psychological debriefing models in the hospital setting among nursing staff, medical trainees, and attending physicians.

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Purpose: The present study explored the extent to which early prelinguistic communication skills predict expressive language in toddlers with autistic siblings (Sibs-autism), who are known to be at high likelihood for autism and language disorder, and a comparison group of toddlers with non-autistic older siblings (Sibs-NA).

Method: Participants were 51 toddlers (29 Sibs-autism, 22 Sibs-NA) aged 12-18 months at the first time point in the study (Time 1). Toddlers were seen again 9 months later (Time 2).

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Article Synopsis
  • Microplastics (MPs), specifically 5 μm polystyrene particles, can accumulate in human organs like the placenta and may pose risks to living organisms, which this study aims to assess through placental tissue analysis.
  • The research involved exposing placental explants to varying concentrations of PS-MPs, measuring cytotoxicity, oxidative stress, and metabolic changes over 24 to 72 hours, utilizing methods like MTT assays and biochemical evaluations.
  • Results showed that exposure to PS-MPs increased cytotoxicity and oxidative stress markers significantly, along with altered metabolomic profiles, indicating potential adverse effects on placental function.
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Background: Two surgical approaches have emerged for axillary staging in cN1 breast cancer patients after neoadjuvant chemotherapy (NAC): sentinel lymph node biopsy (SLNB) and targeted axillary dissection (TAD). Direct comparisons of technical and oncological outcomes with SLNB versus TAD are lacking.

Methods: We routinely performed SLNB from 2017 to 2018 for cN1 breast cancer patients who converted to cN0 after NAC, then adopted TAD from 2019 to 2022.

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Mifepristone as a non-emergency contraceptive among women of reproductive age: a protocol for systematic review and meta-analysis.

BMJ Open

December 2024

WHO Collaborating Centre, Division of Neonatology, Obstetrics, Gynecology, and Reproductive Health, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Article Synopsis
  • Mifepristone is a well-researched contraceptive option that has shown promise in preventing pregnancy, yet there's no comprehensive review summarizing its effectiveness as a non-emergency contraceptive for cisgender girls and women of reproductive age.
  • A systematic review is being conducted to gather and analyze data from various databases, evaluating studies involving mifepristone to assess its contraceptive effectiveness specifically for this population.
  • The review will include data extraction, risk of bias evaluation, and potentially a meta-analysis of the findings, with the final results expected to provide clarity on mifepristone's role in non-emergency contraception by June 2024.
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Chikungunya (CHIKV), o'nyong-nyong (ONNV), and Mayaro (MAYV) viruses are transmitted by mosquitoes and known to cause a debilitating arthritogenic syndrome. These alphaviruses have emerged and re-emerged, leading to outbreaks in tropical and subtropical regions of Asia, South America, and Africa. Despite their prevalence, there persists a critical gap in the availability of sensitive and virus-specific point-of-care (POC) diagnostics.

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  • Pseudoxanthoma elasticum (PXE) is a rare genetic disorder that leads to abnormal calcium deposits in elastic tissue, causing skin changes and other health issues.
  • The study focused on a 13-year-old patient with flare-ups in PXE lesions, leading to a closer examination of the inflammation involved through skin biopsies and various analyses.
  • Findings showed inflammation with T-cell infiltrates in the skin, particularly with a Th1 response, suggesting an inflammatory role in PXE disease, but the exact impact on the condition needs more research.
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Faculty retention in academic OB/GYN: comprehensive strategies and future directions.

J Perinat Med

December 2024

John A. Burns School of Medicine, University of Hawai'i, and Hawai'i Pacific Health Medical Group, Honolulu, Hawaii, USA.

The retention of academic faculty, particularly in the field of Obstetrics and Gynecology (OB/GYN), has become a growing challenge in the post-COVID era. The healthcare landscape has been dramatically altered, leading to a "Great Exit" where a large number of faculty members are resigning or retiring early. This phenomenon is not just a financial burden as recruitment costs have skyrocketed, but also poses a threat to the stability and reputation of academic institutions.

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Since 2017, Hawai'i has had a statute requiring health plans to update their provider directories at least monthly. However, the results of this study suggest that despite this regulation, errors in physician directories may be an ongoing problem. Using publicly available online Medicaid physician directories from Med-QUEST, Hawaii Medical Service Association (HMSA), AlohaCare, 'Ohana Health Plan, and United Healthcare, 473 unique listings for dermatologists were reviewed and 411 (86.

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The Impact of a Commensality Intervention on Physician Burnout.

Hawaii J Health Soc Welf

December 2024

John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (JCS, TBS, HO, KL, MR, SS).

Commensality, the act of eating together, when organized around facilitated discussion is an evidence-based intervention that can promote engagement and reduce physician burnout. The purpose of this pilot study is to evaluate the feasibility, acceptance, and impact of a commensality intervention for physicians. The Commensality Intervention was based on a Mayo Clinic model that consisted of 6, 2-hour dinner meetings at local restaurants over 6 months with facilitated discussion.

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Assessing self-other agreement and dyadic adjustment in marital dyads.

Front Psychol

November 2024

Department of Psychiatry, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States.

Article Synopsis
  • The study investigated how married couples perceive each other's psychological issues and its relationship with their overall marital satisfaction (dyadic adjustment).
  • Couples from different backgrounds (non-clinical, transplant, and divorcing) provided mutual ratings, showing that those with better alignment in perceptions had higher relationship quality.
  • The research highlights that wives' views greatly influence couples' adjustment levels, with significant implications for understanding relationship conflicts and future studies in this area.
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Objective: To analyze the variability in new infliximab biosimilar starts as well as switching from bio-originator to biosimilar infliximab, across insurance payers and rheumatology practices nationally.

Study Setting And Design: Data came from Rheumatology Informatics System for Effectiveness, a national registry with electronic health records from over 1100 US rheumatologists. Key outcomes include ever use of a biosimilar, date of initiation, and date of switching.

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  • The study investigates pyroptosis, a form of programmed cell death, in the context of status epilepticus (SE), a condition marked by prolonged seizures, and how it relates to neurodegeneration.
  • Researchers induced SE in mice using pilocarpine and found increased levels of inflammatory markers and TRPM7 expression, identifying TRPM7 as a key player in neuronal damage and hyperexcitability.
  • The findings suggest that targeting TRPM7 and NLRP3 could be a potential treatment strategy for SE, as inhibiting these pathways alleviated neuronal hyperexcitability and pyroptosis.
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Article Synopsis
  • A patient with moderately severe acute pancreatitis and several serious complications was found to have multisystem inflammatory syndrome in children (MIS-C).
  • The treatment included intravenous immune globulin, corticosteroids, antibiotics, systemic anticoagulation, and drainage of fluid, which resulted in a good response.
  • This case underscores the diverse symptoms of MIS-C and the need for healthcare providers to be vigilant about rare and severe cases that don't improve with standard treatments.
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Objective: Benzodiazepine rescue medications are established as therapy for acute termination of seizure clusters. A post-hoc analysis of a clinical trial of seizure cluster treatment with diazepam nasal spray found a potential longer-term impact over a year of treatment. In this retrospective analysis, we tested the hypothesis that benzodiazepine-treated seizure clusters are associated with prolonged time to the next seizure cluster compared with untreated seizure clusters in a patient-reported real-world database.

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Purpose: With increasing pneumococcal penicillin resistance, physicians treat pneumococcal infections with high-dose amoxicillin (80-90 mg/kg/d). High-dose amoxicillin approaches adult doses which makes clinicians reluctant to exceed "adult doses." This study examines the disparity of amoxicillin dosing between the ages of children.

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  • The study examines the importance of the uterus and its biomechanical properties in supporting healthy pregnancies, identifying how alterations can lead to complications.
  • Researchers analyzed the nonhuman primate (NHP) uterus at different stages of pregnancy to understand its micro-mechanical properties and composition.
  • Key findings showed distinct stiffness and hydration levels in the endometrium-decidua layer, with NHP uterine properties closely resembling human data, affirming NHPs as useful models for human uterine biomechanical studies.
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