6 results match your criteria: "John's Hopkins School of Medicine[Affiliation]"
Relation between non-alcoholic fatty liver disease and carotid artery intimal media thickness as a surrogate for atherosclerosis: a systematic review and meta-analysis.
Eur J Gastroenterol Hepatol
May 2024
Department of Internal Medicine, Icahn School of Medicine at Mount Sinai/NYC Health + Hospitals Queens, New York.
Article Synopsis
- - Non-alcoholic fatty liver disease (NAFLD) includes a range of liver conditions without heavy alcohol use and can lead to serious issues like cirrhosis; the study aimed to explore its connection to carotid intimal media thickness (C-IMT), a marker for heart disease.
- - A comprehensive review of existing studies indicated no significant C-IMT differences for mild to moderate NAFLD when compared to controls, but severe NAFLD did show a notable difference, particularly in those with or without metabolic syndrome.
- - The findings highlight a significant link between NAFLD and increased C-IMT, suggesting the need for C-IMT assessments in NAFLD patients to gauge their cardiovascular
Parkinsonism-dystonia-2: Case-series study from Saudi Arabia.
Ann Clin Transl Neurol
April 2024
Women and Child Institute, John's Hopkins Aramco Healthcare (Jhah), Dhahran, Saudi Arabia.
Parkinsonism-dystonia-2 PKDYS2 is an autosomal-recessive disorder, caused by pathogenic biallelic variants in SLC18A2 which encodes the vesicular monoamine transporter (VMAT2) protein. PKDYS2 is a treatable neurotransmitter disease, and the rate of diagnosis of this disorder has increased significantly with the advance of genomic technologies. Our report highlights a novel pathologic variant in one case and a novel finding on MRI Brain, consisting of a normal symmetrical signal intensity in the dorsal brainstem and pons, and it substantiates the significance of genetic testing in the evaluation of children with developmental delays, which influences clinical decisions to enhance patient outcomes.
View Article and Find Full Text PDFObjective: To examine the factors associated with increased deoxyribonucleic acid fragmentation index (DFI), evaluate the pregnancy outcomes of men with increased DFI, and compare three independent DFI assays.
Design: Secondary analysis.
Setting: Nine US-based fertility centers.
Detection and Characterization of Musculoskeletal Cancer Using Whole-Body Magnetic Resonance Imaging.
Semin Musculoskelet Radiol
December 2020
The Institute of Cancer Research, London, United Kingdom.
Article Synopsis
- - Whole-body magnetic resonance imaging (WB-MRI) is becoming a valuable tool in detecting and staging malignant tumors, especially in the musculoskeletal system.
- - WB-MRI is effective in accurately identifying and measuring disease burdens across various types of cancers, with emerging guidelines advocating its clinical use.
- - This review highlights the advantages and limitations of WB-MRI compared to other imaging technologies, emphasizing its role in assessing both skeletal and soft tissue cancers.
The effect of minocycline on symptoms in schizophrenia: Results from a randomized controlled trial.
Schizophr Res
April 2019
Department of Psychiatry, University of Illinois, Chicago, IL 60607, USA.
Background: Studies have hypothesized that immunological abnormalities might contribute to schizophrenia, and basic science studies, as well as several clinical trials suggest that minocycline could be efficacious in ameliorating both positive and negative symptoms of schizophrenia. In this study we examined the effect of minocycline on schizophrenia in a large randomized controlled trial.
Methods: We performed a 16-week, multi-center, double-blind, randomized, placebo-controlled study on 200 subjects with schizophrenia or schizoaffective disorder randomized to receive either minocycline (200 mg/day, n = 100), or placebo (n = 100) as an add-on to anti-psychotic treatment.
Right ventricular ejection fraction catheter: toy or tool? Con: a premature step.
J Cardiothorac Vasc Anesth
April 1993
Department of Anesthesiology, John's Hopkins School of Medicine, Baltimore, MD.