3 results match your criteria: "Joef Stefan Institute[Affiliation]"
Lysolipid containing liposomes for transendothelial drug delivery.
BMC Res Notes
April 2012
Laboratory of Biophysics, Condensed Matter Physics F5, Joef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
Background: Designing efficient 'vectors', to deliver therapeutics across endothelial barriers, in a controlled manner, remains one of the key goals of drug development. Recently, transcytosis of liposome encapsulated fluorescence marker calcein across a tight cell barrier was studied. The most efficient liposomes were found to be liposomes containing sufficient amount of alkyl phospholipid (APL) perifosine.
View Article and Find Full Text PDFModelling the effect of laminar axially directed blood flow on the dissolution of non-occlusive blood clots.
Phys Med Biol
June 2007
Condensed Matter Physics Department, Joef Stefan Institute, Ljubljana, Slovenia.
Axially directed blood plasma flow can significantly accelerate thrombolysis of non-occlusive blood clots. Viscous forces caused by shearing of blood play an essential role in this process, in addition to biochemical fibrinolytic reactions. An analytical mathematical model based on the hypothesis that clot dissolution dynamics is proportional to the power of the flowing blood plasma dissipated along the clot is presented.
View Article and Find Full Text PDFDifferences in aggregation properties of three site-specific mutants of recombinant human stefin B.
Protein Sci
January 2004
Department of Biochemistry and Molecular Biology, Joef Stefan Institute, 1000 Ljubljana, Slovenia.
Article Synopsis
- The study examines three site-specific mutants of recombinant human stefin B (H75W, P36G, P79S), revealing that they maintain similar structural characteristics compared to the original protein.
- In terms of their molecular behavior, the P36G variant exhibits the highest hydrophobicity and tendency towards amorphous aggregation, while P79S forms dimers and shows a slower rate of amyloid fibril formation.
- Techniques like circular dichroism, gel-filtration, ANS dye binding, and ThT fluorescence were used to characterize these variants, highlighting differences in structure and aggregation tendencies.