Efficient siRNA delivery to murine melanoma cells a novel genipin-based nano-polymer.

Small-interfering RNAs (siRNAs) are therapeutic nucleic acids, often delivered cationic polymers, liposomes, or extracellular vesicles, each method with its limitations. Genipin, a natural crosslinker for primary amines, was explored for siRNA delivery scaffolds. Spermine/genipin-based GS5 polymers were synthesized, showing slightly positive potential at neutral pH and intrinsic fluorescence.