Predictive value of Rockall score for rebleeding and mortality in patients with variceal bleeding.

Objective: To validate Rockall scoring system for in-hospital rebleeding and mortality in cirrhotic patients with variceal bleed.

Study Design: Cohort type of case series.

Place And Duration Of Study: It was carried out at the Department of Gastroenterology and Hepatology, Shaikh Zayed Hospital, Lahore, from March 2005 to March 2006.

Comparison of frequency of wound infection: open vs laparoscopic cholecystectomy.

Background: The objective of this quasi experimental study was to compare the frequency of wound infection between open cholecystectomy (OC) and laparoscopic cholecystectomy (LC) conducted in Surgical Unit IV, Jinnah Hospital Lahore from June 2005 to January 2006.

Methods: 100 patients undergoing elective cholecystectomy for symptomatic gallstones were studied. The patients were allocated in the two groups of 50 each by simple random technique.

Treatment of chronic myeloid leukemia in the imatinib era: perspective from a developing country.

Background: There is paucity of data from developing countries on the efficacy and safety of imatinib mesylate in chronic myeloid leukemia (CML). The primary objective of this study was to document complete and partial cytogenetic responses to imatinib in all phases of CML. Secondary objectives included evaluations of complete hematologic response, safety, time to progression, and survival.

Evaluation of the diagnostic use of free prostate specific antigen/total prostate specific antigen ratio in detecting prostate cancer.

Objective: To assess whether Free/Total prostate specific antigen (PSA) would enhance prostate cancer detection in men with total serum PSA between 2.5 and 10 ng/ml.

Methods: This case control study was conducted in the Department of Urology and Renal Transplantation, Jinnah Hospital, Lahore from January 2001 to June 2004.

Locoregional recurrence after management of carcinoma breast.

Objective: To determine the rate of locoregional recurrence, disease-free interval, site and pattern of locoregional recurrence and the significance of different factors for predicting locoregional recurrence in patients with stage II and III carcinoma breast.

Design: Descriptive study.

Place And Duration Of Study: Surgical Unit-1, Jinnah Hospital, Lahore from September 2001 to December 2002.

The study of thrombocytopenia in sick neonates.

Objective: To determine the number of cases and manifestations of thrombocytopenia in sick neonates.

Design: An observational study.

Place And Duration Of Study: The study was conducted at Neonatal Intensive Care Unit (NICU) of the Paediatric Department, Jinnah Hospital, Lahore from September 1997 to February 1998.

Extremity vascular trauma in Pakistan.

Objective: To report demographic data, etiological spectrum, the varied presentation, certain vascular techniques and their outcome in patients with peripheral vascular trauma.

Methods: This study included the patients who presented to the emergency room of Jinnah Hospital and Allama Iqbal Medical College Complex, Lahore, Pakistan with acute peripheral vascular injuries from May 1998 to April 2002. The Mangled Extremity Severity Score (MESS) was calculated for each individual to determine the magnitude of injury.

Role of digital rectal examination and prostate specific antigen in detecting carcinoma prostate.

Objective: To investigate the ability of digital rectal examination (DRE) and prostate specific antigen (PSA) in detecting carcinoma prostate.

Design: Descriptive cross-sectional study.

Place And Duration Of Study: The study was conducted in the Department of Urology and Renal Transplantation from December 1996 to December 1999.

Prospective evaluation of efficacy and toxicity of 5-fu and folinic acid (Mayo Clinic regimen) in patients with advanced cancer of the gallbladder.

We evaluated the efficacy and toxicity of 5-fluorouracil (5-FU) and folinic acid (Mayo Clinic regimen) in previously untreated patients with advanced gallbladder cancer. Thirty patients with histologically confirmed adenocarcinoma of gallbladder were enrolled on this trial. All were symptomatic and had stage IV disease.