1,445 results match your criteria: "Jinnah Sindh Medical University[Affiliation]"

This critique evaluates a retrospective observational study on the impact of extracorporeal membrane oxygenation (ECMO) treatments on acquired von Willebrand syndrome (AVWS) in patients with out-of-hospital cardiac arrest (OHCA). The study is praised for its detailed observational methodology, robust statistical analyses, and comprehensive overview of patient outcomes. These strengths enhance the applicability of the results to real-world clinical practice.

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Objective: Concept Maps (CM) aid in the acquisition of new information, and comprehend prior knowledge with better retention. Their use is not explored in undergraduate surgical education in our country, hence this study aimed to compare the surgery test scores of undergraduate medical students taught by concept maps and interactive lectures.

Methods: This quasi-experimental study was carried out at the Department of Surgery, at a Private University Hospital among 60 students of fourth year MBBS from 2017-2018.

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Article Synopsis
  • - The study investigates how surgical methods, age, and gender impact recovery from tibia plateau fractures, which are rare but can affect knee function.
  • - Data was collected from 51 patients treated at a hospital, assessing their recovery over 12 months using the Rasmussen scoring scale.
  • - Results showed that while surgical methods and age didn't significantly affect recovery, males had better outcomes than females at the three-month mark, suggesting that gender may play a role in healing.
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  • * Adolescents, who are naturally immersed in digital technology, could greatly benefit from metaverse applications for mental health care, but research on this remains limited.
  • * The article discusses the current state of these technologies for adolescent mental health, highlights challenges in their implementation, and offers suggestions to address these issues.
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  • Malignant neoplasms of bone and articular cartilage, though rare, significantly impact health with rising mortality rates, requiring focused interventions to enhance patient outcomes.
  • A retrospective study analyzed CDC WONDER data on mortality rates among adults aged 65 and older from 1999 to 2020, revealing an initial decline in age-adjusted mortality rates until 2012, followed by a sharp increase.
  • The study found higher mortality rates among men and NH Black individuals, particularly in Southern states and nonmetropolitan areas, indicating a pressing need for targeted public health strategies to address these disparities.
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  • Ectopic ureteroceles are rare in adults but often found in children, typically discovered during pregnancy ultrasounds or through UTI symptoms.
  • A 24-year-old woman faced recurrent UTIs and severe urinary retention due to a large ectopic ureterocele, confirmed through imaging and cystoscopy.
  • The minimally invasive treatment led to her full recovery and emphasizes the need to consider ectopic ureteroceles in adult women with frequent urinary issues.
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Glioblastoma (GB), the most common malignant brain tumour, has a poor prognosis despite advances in treatment. Standard management involves surgery followed by chemoradiotherapy. MRI-guided laser interstitial thermal therapy (LITT) is a minimally invasive technique that may offer an option for select patients with specific clinical profiles.

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Chromosomal trisomy presents with a range of clinical manifestations, from subtle to life-threatening conditions that include trisomy 16, the most common aneuploidy in first trimester abortions. Most cases are linked to maternal complications and spontaneous abortions, typically detected prenatally. Infants who survive with trisomy 16 often have mosaic variants and may exhibit various anatomical and metabolic abnormalities, though a trisomy 16 diagnosis does not guarantee the presence of such abnormalities.

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Atrial fibrillation (AF) is a prevalent cardiac arrhythmia. Direct oral anticoagulants (DOACs), with superior efficacy and safety, have emerged as a promising alternative to warfarin. This systematic review and meta-analysis aimed to compare the safety and efficacy of DOACs and warfarin in patients with AF and chronic liver disease (CLD).

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Introduction: Acute subdural hematomas are major causes of morbidity which warrant immediate treatment. If surgical intervention is warranted, craniotomy (CO) and decompressive craniectomy (DC) are employed, largely based on a loosely defined criteria and the neurosurgeon's best judgment. The primacy of one approach over another is a matter of dispute.

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Malaria is a significant public health challenge in the Democratic Republic of the Congo (DR Congo), with a high prevalence and mortality rate, particularly among children under five years old. This study examines the impact of malaria in eastern DR Congo, where armed conflict and humanitarian crises have resulted in overcrowded refugee and internally displaced persons (IDP) camps, exacerbating malaria transmission. Malnutrition, limited access to healthcare, and poor living conditions makes children under the age of five particularly vulnerable.

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Article Synopsis
  • Cold agglutinin-induced hemolytic anemia poses diagnostic challenges, especially in resource-limited settings like Pakistan, highlighted by a case of a 92-year-old male with severe anemia and altered consciousness.
  • Diagnosis was confirmed through positive Direct Coombs test and elevated cold agglutinin titers, demonstrating the importance of specific lab findings in identifying the condition.
  • Multidisciplinary management, including blood transfusions and immunosuppressive therapy, resolved the patient's symptoms, underscoring the need for enhanced clinician awareness and timely interventions for better patient outcomes.
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Leiomyomas are benign smooth muscle tumors predominantly found in the uterine wall, with rare occurrences in the gastrointestinal tract. Here, we report a rare case of a leiomyoma that was incidentally found in the rectum of an asymptomatic male who underwent a routine screening colonoscopy. Histopathological examination confirmed the diagnosis of leiomyoma.

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Cardiovascular complications following non-cardiac surgery pose a significant global concern, affecting millions of patients annually. These complications, ranging from asymptomatic troponin elevations to major adverse cardiac events, contribute to heightened morbidity, mortality, and health care expenditures. The underlying mechanisms involve oxygen supply-demand imbalances and acute coronary syndromes precipitated by perioperative stressors.

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Development and characterisation of orally disintegrating flurbiprofen tablets using SeDeM-ODT tool.

PLoS One

October 2024

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

Article Synopsis
  • The study focused on using the SeDeM-ODT parametric tests to evaluate ludipress as a directly compressible excipient for creating flurbiprofen orally disintegrating tablets (ODTs).
  • All nine powder blends tested showed appropriate compressibility and bucodispersibility, indicating that direct compression is a suitable method for tablet production.
  • The formulations underwent various tests for hardness and disintegration, and stability studies showed a shelf life of about 51-56 months, with dissolution studies indicating they followed the Higuchi kinetic model.
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