Comparison of the Performance of the Warfarin Pharmacogenetics Algorithms in Patients with Surgery of Heart Valve Replacement and Heart Valvuloplasty.

A large number of warfarin pharmacogenetics algorithms have been published. Our research was aimed to evaluate the performance of the selected pharmacogenetic algorithms in patients with surgery of heart valve replacement and heart valvuloplasty during the phase of initial and stable anticoagulation treatment. 10 pharmacogenetic algorithms were selected by searching PubMed.

Bioinformatics analysis of gene expression profiles of osteoarthritis.

This study aimed to explore the underlying molecular mechanisms of osteoarthritis (OA) by bioinformatics analysis. Synovial tissue samples from five OA and five normal donors (ND) were used to identify the differentially expressed genes (DEGs) by paired t-test. Pathway enrichment analysis of DEGs was performed, followed by construction of a protein-protein interaction (PPI) network.

Expression and clinical significance of the programmed cell death 5 gene and protein in laryngeal squamous cell carcinoma.

Objective: To determine the expression of the gene programmed cell death 5 (PDCD5) and its protein PDCD5 in laryngeal squamous cell carcinoma and to analyse possible correlations with clinicopathological parameters.

Methods: PDCD5 mRNA expression was assessed using reverse transcription-polymerase chain reaction and expression of PDCD5 protein was studied using Western blot analysis and immunohistochemistry in laryngeal squamous cell carcinoma and morphologically normal para-carcinoma tissue.

Results: A total of 41 laryngeal squamous cell carcinoma and 29 normal para-carcinoma tissue specimens were examined.

Occupational cooking and risk of uveal melanoma: a meta-analysis.

Background: Many observational studies have assessed the possible association between occupational cooking and uveal melanoma risk, but reported results are controversial. Our goal was to evaluate the association between occupational cooking and uveal melanoma risk by conducting a meta-analysis of observational studies.

Methods: PubMed, EMBASE, and Web of Science were searched through June 2012 to identify all eligible studies.

Selective ovary resistance to insulin signaling in women with polycystic ovary syndrome.

Objective: Insulin resistance is a common feature of both polycystic ovary syndrome (PCOS) and non-insulin-dependent diabetes mellitus (NIDDM); however, the persistent reproductive disturbances appear to be limited to the former, suggesting that insulin resistance in the ovary itself may confer this susceptibility.

Design: Prospective study.

Setting: University-affiliated department.

Ovarian-adrenal cross-talk in polycystic ovary syndrome: evidence from wedge resection.

Objective: To determine whether the ovary influences adrenal androgen secretion in women with polycystic ovary syndrome (PCOS).

Design: Six PCOS-affected patients with clomiphene resistance and gonadotrophin hyperresponsivity, and six controls with regular ovulatory cycles, matched for age and body mass index.

Methods: Bilateral ovarian wedge resection was performed to induce ovulation surgically for these refractory women with PCOS.