3 results match your criteria: "Jining No.1 People's Hospital affiliated to Shandong First Medical University[Affiliation]"

Immunoglobulin E, the potential accelerator of comorbid psoriasis and atherosclerosis.

Biomed Pharmacother

January 2025

Laboratory of Medical Mycology & Department of Dermatology, Jining No.1 People's Hospital affiliated to Shandong First Medical University, Jining, Shandong, China. Electronic address:

Immunoglobulin (Ig) E is a key mediator in the induction and maintenance of allergic inflammation, characterized by a Th2-dominated immune response. Recently epidemiological studies have showed that elevated serum total IgE levels or an increased abundance of mast cells (MCs) at the lesion site are observed in psoriatic patients with cardiovascular diseases (CVD), such as atherosclerosis. Although the underlying mechanisms by which IgE synergizing with MCs in promoting these chronic immune-inflammatory diseases remain unclear, the interleukin (IL)-23/IL-17 axis appears to play a crucial role in comorbidity of psoriasis and atherosclerosis.

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Article Synopsis
  • Candidemia is hard to diagnose due to vague symptoms, and delays in treatment can lead to higher death rates, especially in ICU patients.
  • The study involved creating a machine learning model to diagnose candidemia early by analyzing data from 334 ICU patients at Ji Ning NO.1 People's Hospital in China, with further validation on an additional 77 patients.
  • Utilizing the random forest algorithm, the model achieved a high accuracy rate (AUC of 0.87 for internal validation, 0.83 for external), identifying total bilirubin and age as key predictors, which could lead to better patient outcomes through earlier intervention.
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Intranodal palisaded myofibroblastoma (IPM) is a rare benign tumor of the lymph nodes, particularly in inguinal lymph nodes. IPM originating from the submandibular gland lymph nodes is rarely encountered in clinical practice. Herein, we report the case of a 31-year-old male patient with IPM of the submandibular gland region and describe in detail magnetic resonance imaging findings and pathology.

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