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As an important gaseous pollutant, SO derivatives generally exist and significantly threaten the environment and organism health. Meanwhile, polarity is a disease-related indicator in the organism's microenvironment, where an unregulated variation may disturb the physiological metabolisms. Hence, a superior FRET-based fluorescent sensor (TLA) is presented to track polarity and sulfur dioxide derivatives by dual emission channel, an elevated red emission at 633 nm with decreasing polarity as well as a reduced red emission at 633 nm and improved blue emission at 449 nm with increasing concentration of SO derivatives.
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