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Celastrol inhibits colon cancer cell proliferation by downregulating miR-21 and PI3K/AKT/GSK-3β pathway.
Int J Clin Exp Pathol
March 2019
Department of Anorectal Surgery, Jinhua Hospital of Zhejiang University (Jinhua Central Hospital) 351 Mingyue Street, Wucheng District, Jinhua 321000, China.
Celastrol is a traditional Chinese medicine, that is derived from Tripterygium wilfordii. It has been proposed to offer anti-tumor potential. MicroRNAs also play important roles in tumorigenesis.
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